HCSGD entry for TLE1
1. General information
| Official gene symbol | TLE1 |
|---|---|
| Entrez ID | 7088 |
| Gene full name | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) |
| Other gene symbols | ESG ESG1 GRG1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001106 | RNA polymerase II transcription corepressor activity | IDA | molecular_function |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IMP | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005667 | Transcription factor complex | IEA | cellular_component |
| GO:0005829 | Cytosol | IMP | cellular_component |
| GO:0006366 | Transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007219 | Notch signaling pathway | TAS | biological_process |
| GO:0007275 | Multicellular organismal development | TAS | biological_process |
| GO:0008134 | Transcription factor binding | IDA IPI | molecular_function |
| GO:0009887 | Organ morphogenesis | TAS | biological_process |
| GO:0010628 | Positive regulation of gene expression | IMP | biological_process |
| GO:0016055 | Wnt signaling pathway | IEA | biological_process |
| GO:0030178 | Negative regulation of Wnt signaling pathway | NAS | biological_process |
| GO:0043124 | Negative regulation of I-kappaB kinase/NF-kappaB signaling | IDA | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IDA | biological_process |
| GO:2000811 | Negative regulation of anoikis | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7405430645 | 0.2835363854 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0901243105 |
| GSE13712_SHEAR | Up | 0.0304846610 |
| GSE13712_STATIC | Down | -0.0388718441 |
| GSE19018 | Up | 0.0165896476 |
| GSE19899_A1 | Down | -0.1780504731 |
| GSE19899_A2 | Up | 0.0354750712 |
| PubMed_21979375_A1 | Down | -0.1196135569 |
| PubMed_21979375_A2 | Down | -0.1570564934 |
| GSE35957 | Up | 0.5280338316 |
| GSE36640 | Down | -0.3356606554 |
| GSE54402 | Down | -0.0652710723 |
| GSE9593 | Up | 0.0411403812 |
| GSE43922 | Down | -0.2817387782 |
| GSE24585 | Down | -0.0346332441 |
| GSE37065 | Up | 0.2859610195 |
| GSE28863_A1 | Up | 0.2293062841 |
| GSE28863_A2 | Down | -0.0827407685 |
| GSE28863_A3 | Down | -0.2225468964 |
| GSE28863_A4 | Down | -0.0314310023 |
| GSE48662 | Down | -0.0442942896 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-657 | MIMAT0003335 | MIRT007104 | Luciferase reporter assay//Western blot | Functional MTI | 23175432 |
| hsa-miR-191-5p | MIMAT0000440 | MIRT021488 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039611 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-423-3p | MIMAT0001340 | MIRT042606 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
