HCSGD entry for TK1
1. General information
| Official gene symbol | TK1 |
|---|---|
| Entrez ID | 7083 |
| Gene full name | thymidine kinase 1, soluble |
| Other gene symbols | TK2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001889 | Liver development | IEA | biological_process |
| GO:0004797 | Thymidine kinase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006139 | Nucleobase-containing compound metabolic process | TAS | biological_process |
| GO:0006206 | Pyrimidine nucleobase metabolic process | TAS | biological_process |
| GO:0006260 | DNA replication | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IDA | molecular_function |
| GO:0009157 | Deoxyribonucleoside monophosphate biosynthetic process | TAS | biological_process |
| GO:0009165 | Nucleotide biosynthetic process | EXP TAS | biological_process |
| GO:0009636 | Response to toxic substance | IEA | biological_process |
| GO:0014856 | Skeletal muscle cell proliferation | IEA | biological_process |
| GO:0019206 | Nucleoside kinase activity | EXP | molecular_function |
| GO:0031667 | Response to nutrient levels | IEA | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0043097 | Pyrimidine nucleoside salvage | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046104 | Thymidine metabolic process | IEA | biological_process |
| GO:0046688 | Response to copper ion | IEA | biological_process |
| GO:0048565 | Digestive tract development | IEA | biological_process |
| GO:0051289 | Protein homotetramerization | IPI | biological_process |
| GO:0051414 | Response to cortisol | IEA | biological_process |
| GO:0055086 | Nucleobase-containing small molecule metabolic process | TAS | biological_process |
| GO:0060138 | Fetal process involved in parturition | IEA | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9148741955 | 0.0000150716 | 0.9999902473 | 0.0075452830 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.7504031796 |
| GSE13712_SHEAR | Down | -0.0975514164 |
| GSE13712_STATIC | Down | -0.3712013185 |
| GSE19018 | Up | 0.1885775171 |
| GSE19899_A1 | Down | -2.0619972236 |
| GSE19899_A2 | Down | -4.6598720337 |
| PubMed_21979375_A1 | Down | -2.2470813485 |
| PubMed_21979375_A2 | Down | -5.5897107725 |
| GSE35957 | Down | -4.1974847401 |
| GSE36640 | Down | -4.2953265793 |
| GSE54402 | Down | -1.3626514971 |
| GSE9593 | Down | -1.6339391812 |
| GSE43922 | Down | -2.1894676522 |
| GSE24585 | Up | 0.6061701685 |
| GSE37065 | Down | -0.7187884837 |
| GSE28863_A1 | Down | -0.1061163587 |
| GSE28863_A2 | Up | 0.4304418394 |
| GSE28863_A3 | Down | -0.1632999499 |
| GSE28863_A4 | Up | 0.2005647442 |
| GSE48662 | Down | -2.3176056115 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Entries Per Page
Displaying Page of
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Dithioerythritol | DB01692 | EXPT01292 |
| Thymidine-5'-Triphosphate | DB02452 | EXPT03131 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016357 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029423 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-186-3p | MIMAT0004612 | MIRT038616 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-103a-3p | MIMAT0000101 | MIRT048356 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 8934878 | T[K1] is a T antigen point mutant that selectively is defective in binding pRb and the pRb-related proteins p107 and p130 |
| 8934878 | We show that T[K1] stimulated quiescent human fibroblasts to synthesize DNA nearly as well as wild-type T but was incapable of stimulating senescent cells |
| 8934878 | We tested several growth regulatory genes that are repressed in senescent cells for ability to restore activity to T[K1] |
| 8934878 | Only the helix-loop-helix (HLH) protein, Id-1, restored the ability of T[K1] to reactivate DNA synthesis in senescent cells |
Entries Per Page
Displaying Page of
