HCSGD entry for TJP1
1. General information
| Official gene symbol | TJP1 |
|---|---|
| Entrez ID | 7082 |
| Gene full name | tight junction protein 1 |
| Other gene symbols | ZO-1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001825 | Blastocyst formation | IEA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005516 | Calmodulin binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA TAS | cellular_component |
| GO:0005913 | Cell-cell adherens junction | IEA | cellular_component |
| GO:0005921 | Gap junction | IEA | cellular_component |
| GO:0005923 | Tight junction | IDA IEA | cellular_component |
| GO:0006915 | Apoptotic process | TAS | biological_process |
| GO:0006921 | Cellular component disassembly involved in execution phase of apoptosis | TAS | biological_process |
| GO:0007043 | Cell-cell junction assembly | TAS | biological_process |
| GO:0008022 | Protein C-terminus binding | IEA | molecular_function |
| GO:0014704 | Intercalated disc | IEA | cellular_component |
| GO:0016323 | Basolateral plasma membrane | IDA | cellular_component |
| GO:0016324 | Apical plasma membrane | IEA | cellular_component |
| GO:0016327 | Apicolateral plasma membrane | IEA | cellular_component |
| GO:0019904 | Protein domain specific binding | IEA | molecular_function |
| GO:0030054 | Cell junction | IDA | cellular_component |
| GO:0032496 | Response to lipopolysaccharide | IEA | biological_process |
| GO:0035329 | Hippo signaling | TAS | biological_process |
| GO:0042493 | Response to drug | IEA | biological_process |
| GO:0043116 | Negative regulation of vascular permeability | IEA | biological_process |
| GO:0043296 | Apical junction complex | IDA | cellular_component |
| GO:0045177 | Apical part of cell | IDA | cellular_component |
| GO:0045471 | Response to ethanol | IEA | biological_process |
| GO:0046581 | Intercellular canaliculus | IEA | cellular_component |
| GO:0071000 | Response to magnetism | IEA | biological_process |
| GO:0071333 | Cellular response to glucose stimulus | IEA | biological_process |
| GO:1901350 | Cell-cell signaling involved in cell-cell junction organization | NAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0466160594 | 0.9487472095 | 0.4780696922 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0137035791 |
| GSE13712_SHEAR | Down | -0.0231377390 |
| GSE13712_STATIC | Down | -0.4559487330 |
| GSE19018 | Up | 0.2574153882 |
| GSE19899_A1 | Up | 0.4024470943 |
| GSE19899_A2 | Up | 0.1264649511 |
| PubMed_21979375_A1 | Up | 0.6961013925 |
| PubMed_21979375_A2 | Up | 0.2382470092 |
| GSE35957 | Up | 0.4064923536 |
| GSE36640 | Up | 0.4554266860 |
| GSE54402 | Down | -0.1770526378 |
| GSE9593 | Up | 0.0224750884 |
| GSE43922 | Down | -0.0199712487 |
| GSE24585 | Up | 0.2126524925 |
| GSE37065 | Up | 0.0907112119 |
| GSE28863_A1 | Up | 0.6453040534 |
| GSE28863_A2 | Up | 0.6477342561 |
| GSE28863_A3 | Up | 0.0034434437 |
| GSE28863_A4 | Up | 0.1467620862 |
| GSE48662 | Down | -0.0046128870 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-212-3p | MIMAT0000269 | MIRT004341 | Western blot//Luciferase reporter assay | Functional MTI | 18162065 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT020884 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039699 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042969 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050793 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT051942 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-212-3p | MIMAT0000269 | NA | hsa-miR-212 | {Western blot} | {overexpression by miRNA precursor transfection} | 18162065 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23557734 | The barrier structures of RPE cells were detected by actin-tracker, ZO-1, claudin-19, occludin immunochemistry, and Western blot; barrier function was analyzed by measuring transepithelial resistance (TER) and transepithelial diffusion rate of FITC-dextran |
| 21526120 | Fluorescence-labelled staining for E-Cadherin, F-actin and ZO-1 in vivo revealed different patterns with significantly increased expression on central RPE cells than those in the periphery or differences in junctional morphology |
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