HCSGD entry for TIMP3
1. General information
| Official gene symbol | TIMP3 |
|---|---|
| Entrez ID | 7078 |
| Gene full name | TIMP metallopeptidase inhibitor 3 |
| Other gene symbols | HSMRK222 K222 K222TA2 SFD |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005604 | Basement membrane | IEA | cellular_component |
| GO:0007601 | Visual perception | IEA | biological_process |
| GO:0008191 | Metalloendopeptidase inhibitor activity | TAS | molecular_function |
| GO:0010951 | Negative regulation of endopeptidase activity | TAS | biological_process |
| GO:0031012 | Extracellular matrix | IDA | cellular_component |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0051045 | Negative regulation of membrane protein ectodomain proteolysis | IMP | biological_process |
| GO:0052548 | Regulation of endopeptidase activity | TAS | biological_process |
| GO:0071310 | Cellular response to organic substance | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6274665058 | 0.0048469017 | 0.9999902473 | 0.1418008889 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.5210110152 |
| GSE13712_SHEAR | Down | -0.3771238045 |
| GSE13712_STATIC | Down | -0.3708417481 |
| GSE19018 | Down | -0.6102841933 |
| GSE19899_A1 | Down | -0.1005672718 |
| GSE19899_A2 | Down | -1.5493502071 |
| PubMed_21979375_A1 | Down | -0.5796987708 |
| PubMed_21979375_A2 | Down | -1.1856037360 |
| GSE35957 | Up | 0.4728794768 |
| GSE36640 | Up | 1.5284303086 |
| GSE54402 | Down | -2.2356949012 |
| GSE9593 | Down | -0.2379580571 |
| GSE43922 | Down | -0.2006445631 |
| GSE24585 | Down | -0.7211514609 |
| GSE37065 | Up | 0.2224261412 |
| GSE28863_A1 | Up | 0.5255958627 |
| GSE28863_A2 | Down | -0.0397612859 |
| GSE28863_A3 | Up | 0.2492238820 |
| GSE28863_A4 | Down | -0.0645874019 |
| GSE48662 | Down | -0.0561406205 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| pimagedine HCl | DB05383 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-181b-5p | MIMAT0000257 | MIRT000637 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20023698 |
| hsa-miR-181b-5p | MIMAT0000257 | MIRT000637 | Immunohistochemistry//In situ hybridization//qRT-PCR//Western blot | Functional MTI | 22009755 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT000954 | Luciferase reporter assay//Western blot//qRT-PCR//Reporter assay;Western blot;qRT-PCR;Microarray;Other | Functional MTI | 18591254 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT000954 | qRT-PCR//Luciferase reporter assay//Western blot | Functional MTI | 20346171 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT000954 | Luciferase reporter assay//Western blot | Functional MTI | 21820586 |
| hsa-miR-1 | MIMAT0000416 | MIRT002807 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-1 | MIMAT0000416 | MIRT002807 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT003452 | Flow//Immunohistochemistry//Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 19962668 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT003452 | Immunohistochemistry//In situ hybridization//qRT-PCR//Western blot | Functional MTI | 22009755 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT003452 | ELISA//Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 22681957 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT003451 | Flow//Immunohistochemistry//Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 19962668 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT003451 | Immunohistochemistry//In situ hybridization//qRT-PCR//Western blot | Functional MTI | 22009755 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT003451 | ELISA//Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 22681957 |
| hsa-miR-103a-3p | MIMAT0000101 | MIRT006991 | Luciferase reporter assay | Functional MTI | 22783422 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT017742 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022537 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-423-5p | MIMAT0004748 | MIRT038122 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30c-2-3p | MIMAT0004550 | MIRT038689 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18b-5p | MIMAT0001412 | MIRT042404 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051091 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051454 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | NA | hsa-miR-1 | 15685193 | |||
| hsa-miR-21-5p | MIMAT0000076 | NA | hsa-miR-21 | {Western blot} | {downregulation by 2'-O-Me antisense miRNA oligonucleotide} | 18591254 | |
| hsa-miR-221-3p | MIMAT0000278 | 1 | hsa-miR-221 | {Western blot} | {overexpression} | 22009755 | |
| hsa-miR-222-3p | MIMAT0000279 | 1 | hsa-miR-222 | {Western blot} | {overexpression} | 22009755 | |
| hsa-miR-181b-5p | MIMAT0000257 | 1 | hsa-miR-181b | {Western blot} | {overexpression} | 22009755 | |
| hsa-miR-181b-5p | MIMAT0000257 | 2 | hsa-miR-181b | {Western blot} | {overexpression} | 22009755 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 10576245 | Both the NUV-irradiated RPE cells and RPE cells at 20 Pd expressed 4 to 8-fold and 2 to 4-fold less PEDF and TIMP-3 genes, respectively |
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