HCSGD entry for TIMP2
1. General information
| Official gene symbol | TIMP2 |
|---|---|
| Entrez ID | 7077 |
| Gene full name | TIMP metallopeptidase inhibitor 2 |
| Other gene symbols | CSC-21K DDC8 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005178 | Integrin binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | IEA TAS | cellular_component |
| GO:0005604 | Basement membrane | IEA | cellular_component |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0007417 | Central nervous system development | IEA | biological_process |
| GO:0007568 | Aging | IEA | biological_process |
| GO:0008047 | Enzyme activator activity | IEA | molecular_function |
| GO:0008191 | Metalloendopeptidase inhibitor activity | IEA | molecular_function |
| GO:0008285 | Negative regulation of cell proliferation | IEA | biological_process |
| GO:0009986 | Cell surface | IEA | cellular_component |
| GO:0010951 | Negative regulation of endopeptidase activity | TAS | biological_process |
| GO:0022617 | Extracellular matrix disassembly | TAS | biological_process |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0030426 | Growth cone | IEA | cellular_component |
| GO:0032487 | Regulation of Rap protein signal transduction | IEA | biological_process |
| GO:0034097 | Response to cytokine | IEA | biological_process |
| GO:0042493 | Response to drug | IEA | biological_process |
| GO:0043025 | Neuronal cell body | IEA | cellular_component |
| GO:0043410 | Positive regulation of MAPK cascade | IEA | biological_process |
| GO:0045666 | Positive regulation of neuron differentiation | IEA | biological_process |
| GO:0045762 | Positive regulation of adenylate cyclase activity | IEA | biological_process |
| GO:0045861 | Negative regulation of proteolysis | IEA | biological_process |
| GO:0045930 | Negative regulation of mitotic cell cycle | IEA | biological_process |
| GO:0046580 | Negative regulation of Ras protein signal transduction | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0052548 | Regulation of endopeptidase activity | TAS | biological_process |
| GO:0071310 | Cellular response to organic substance | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2361848030 | 0.8764983625 | 0.9197963160 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1086391407 |
| GSE13712_SHEAR | Up | 0.3837887205 |
| GSE13712_STATIC | Up | 0.2972511496 |
| GSE19018 | Up | 0.3380269099 |
| GSE19899_A1 | Down | -0.0920249707 |
| GSE19899_A2 | Up | 0.2861250802 |
| PubMed_21979375_A1 | Down | -0.6866753746 |
| PubMed_21979375_A2 | Up | 0.1614933215 |
| GSE35957 | Up | 0.0975533526 |
| GSE36640 | Up | 0.3962736418 |
| GSE54402 | Down | -0.2249590687 |
| GSE9593 | Up | 0.6591102606 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.0037428302 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-519d-3p | MIMAT0002853 | MIRT006198 | Luciferase reporter assay//Western blot | Functional MTI | 22262409 |
| hsa-miR-519c-3p | MIMAT0002832 | MIRT006639 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 22262409 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27206970 | Testosterone increased the expression of tissue inhibitor of metalloproteinase-2 but decreased the expression of MMP-2 and membrane type-1 metalloproteinase which contributed to increase MMP-2 activity |
| 22385081 | In contrast, the tissue inhibitors of metalloproteinases, TIMP-1 and TIMP-2, were increased in 10/11 OSMF fibroblast cultures relative to normal and non-diseased paan user controls |
| 22385081 | TIMP levels correlated with replicative lifespan of the cultures but not with the presence of senescent cells, as senescent cell depletion in OSMF fibroblast cultures did not result in a reduction in either TIMP-1 or TIMP-2 |
| 22385081 | However, the introduction of unrepairable DDBs into normal oral fibroblasts by ionizing radiation increased TIMP-1 and TIMP-2 secretion by two-fold and seven-fold, respectively, within 5 days, replicating early senescence and the elevation seen in OSMF cultures |
| 19085240 | Gene expression analysis further showed that mRNA levels for bFGF, PDGF-1, and TIMP-2 were not affected by aging (p > 0 |
| 12883667 | However, we were unable to demonstrate any differences in the constitutive productions and secretions of MMP-2, MT1-MMP, and TIMP-2, among the mock-treated, Ad-lacZ-transduced, and Ad-p16-transduced cells |
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