HCSGD entry for THY1
1. General information
| Official gene symbol | THY1 |
|---|---|
| Entrez ID | 7070 |
| Gene full name | Thy-1 cell surface antigen |
| Other gene symbols | CD90 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001525 | Angiogenesis | IEA ISS | biological_process |
| GO:0005100 | Rho GTPase activator activity | IEA ISS | molecular_function |
| GO:0005178 | Integrin binding | IPI | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0005886 | Plasma membrane | ISS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006469 | Negative regulation of protein kinase activity | IEA ISS | biological_process |
| GO:0007010 | Cytoskeleton organization | IEA ISS | biological_process |
| GO:0009897 | External side of plasma membrane | ISS | cellular_component |
| GO:0016324 | Apical plasma membrane | IDA | cellular_component |
| GO:0016337 | Cell-cell adhesion | IEA ISS | biological_process |
| GO:0019901 | Protein kinase binding | IEA | molecular_function |
| GO:0030336 | Negative regulation of cell migration | IEA ISS | biological_process |
| GO:0030425 | Dendrite | IEA | cellular_component |
| GO:0030426 | Growth cone | IEA ISS | cellular_component |
| GO:0031362 | Anchored component of external side of plasma membrane | IEA | cellular_component |
| GO:0034235 | GPI anchor binding | IEA ISS | molecular_function |
| GO:0043547 | Positive regulation of GTPase activity | ISS | biological_process |
| GO:0045121 | Membrane raft | IEA NAS | cellular_component |
| GO:0046549 | Retinal cone cell development | IEA ISS | biological_process |
| GO:0048041 | Focal adhesion assembly | IEA ISS | biological_process |
| GO:0050771 | Negative regulation of axonogenesis | IEA ISS | biological_process |
| GO:0050852 | T cell receptor signaling pathway | IEA ISS | biological_process |
| GO:0050860 | Negative regulation of T cell receptor signaling pathway | IEA ISS | biological_process |
| GO:0050870 | Positive regulation of T cell activation | IEA ISS | biological_process |
| GO:0051281 | Positive regulation of release of sequestered calcium ion into cytosol | IEA ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7777039778 | 0.0045466738 | 0.9999902473 | 0.1363018223 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2524899757 |
| GSE13712_SHEAR | Down | -0.0035234305 |
| GSE13712_STATIC | Down | -0.1603808151 |
| GSE19018 | Down | -0.1084428818 |
| GSE19899_A1 | Down | -2.0227860930 |
| GSE19899_A2 | Down | -1.1477394941 |
| PubMed_21979375_A1 | Down | -2.0283468597 |
| PubMed_21979375_A2 | Down | -1.9150872658 |
| GSE35957 | Up | 0.1153012927 |
| GSE36640 | Up | 0.2873169615 |
| GSE54402 | Down | -2.4658393018 |
| GSE9593 | Up | 1.6725259730 |
| GSE43922 | Down | -0.8636334701 |
| GSE24585 | Down | -0.0928730607 |
| GSE37065 | Down | -0.4537735673 |
| GSE28863_A1 | Down | -0.0133371960 |
| GSE28863_A2 | Up | 0.1967265350 |
| GSE28863_A3 | Down | -0.0339568188 |
| GSE28863_A4 | Up | 0.1887399462 |
| GSE48662 | Up | 0.1511995943 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT024103 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 16 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27579045 | Mesenchymal stem cells were successfully generated and characterized as delineated by the expressions of CD90 |
| 26196672 | CD90 was high for BMA13 (84 |
| 25437179 | When compared with N-UC-MSCs, GDM-UC-MSCs showed decreased cell growth and earlier cellular senescence with accumulation of p16 and p53, even though they expressed similar levels of CD105, CD90, and CD73 MSC marker proteins |
| 24170370 | 5 cc of bone marrow was needed to predictably isolate aBMSCs, and, regardless of methodology for harvest, cell-surface marker expression of CD73, CD90, CD105, and Stro-1 was similar for aBMSCs, being 89 |
| 24052950 | We report an improved prospective clonal isolation technique and reveal that the combination of three cell-surface markers (LNGFR, THY-1, and VCAM-1) allows for the selection of highly enriched clonogenic cells (one out of three isolated cells) |
| 23106472 | The cells harvested by both methods gave positive results for CD44 and CD90 and negative results for CD34 and CD45 |
| 22721583 | Both PB-MSCs and BM-MSCs were positive for CD44 and CD90, and negative for CD34 and CD45 |
| 22242193 | Long term treatment did not induce lineage commitment in terms of osteogenic pathways but maintained their clonogenic capacity, their surface marker characteristics (expression of CD73, CD90, CD105) and their multipotency to develop towards the chondrogenic, adipogenic and osteogenic pathways |
| 21669046 | Therefore, we used Thy1(+) (oval) and CD44(+) (small hepatocytes) cells isolated from GalN-treated rat livers as hepatic stem and progenitor cells, respectively |
| 21627568 | The surface expression of CD90 and CD73 was assessed by flow cytometry |
| 20225285 | The expressions of CD166, CD49a, and CD106 decreased, whereas those of CD10, CD29, CD44, CD73, CD90, and CD105 showed no significant change |
| 20132052 | FACS analysis confirmed expression of the stem cell markers CD44, CD90, CD105, and CD166, but negative expression of CD34 and CD45 ruling out a hematopoietic or fibrocyte origin for these progenitors |
| 17951672 | Surface markers that can be used to characterize FLS include positive staining for VCAM-1, CD44, CD55, CD90 (Thy-1), and cadherin-11, coupled with the absence of macrophage markers such as CD14 or CD68 |
| 17371154 | Flow cytometric analysis indicated a strong need to investigate for novel cell-surface characteristic markers of BMSCs because there was no obvious difference in the expression of the selected characteristic BMSC cell surface markers CD29, CD44, CD90, CD105, and CD166 between fast-growing and slow-growing clones |
| 16229018 | There was a high expression of CD90, CD29, CD44 and CD105 and variable and moderate expression of CD166 and CD106 at the start of MSC culture and at each passage during expansion |
| 1303099 | Using immunofluorescence microscopy, the percentages of Thy-1 |
| 1303099 | 2+, Lyt-1+, and Lyt-2+ cells in different anatomical immune tissues did not change with age, except in the BLN and PP where there were significant age-related declines of the percentages of Thy-1 |
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