HCSGD entry for THRB
1. General information
| Official gene symbol | THRB |
|---|---|
| Entrez ID | 7068 |
| Gene full name | thyroid hormone receptor, beta |
| Other gene symbols | C-ERBA-2 C-ERBA-BETA ERBA2 GRTH NR1A2 PRTH THR1 THRB1 THRB2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0003677 | DNA binding | TAS | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | NAS | molecular_function |
| GO:0003707 | Steroid hormone receptor activity | IEA | molecular_function |
| GO:0003714 | Transcription corepressor activity | TAS | molecular_function |
| GO:0004887 | Thyroid hormone receptor activity | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA TAS | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | TAS | biological_process |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | TAS | biological_process |
| GO:0007605 | Sensory perception of sound | IEA | biological_process |
| GO:0007621 | Negative regulation of female receptivity | IEA | biological_process |
| GO:0008016 | Regulation of heart contraction | IEA | biological_process |
| GO:0008050 | Female courtship behavior | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0009887 | Organ morphogenesis | IEA | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0030522 | Intracellular receptor signaling pathway | IDA TAS | biological_process |
| GO:0031490 | Chromatin DNA binding | IEA | molecular_function |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0060509 | Type I pneumocyte differentiation | IEA | biological_process |
| GO:0070324 | Thyroid hormone binding | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0294267619 | 0.9401944531 | 0.3973587179 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0608302337 |
| GSE13712_SHEAR | Down | -0.2155726332 |
| GSE13712_STATIC | Down | -0.0523921099 |
| GSE19018 | Down | -0.0592148048 |
| GSE19899_A1 | Up | 0.2876561704 |
| GSE19899_A2 | Up | 0.2952326118 |
| PubMed_21979375_A1 | Up | 0.2618946846 |
| PubMed_21979375_A2 | Up | 0.2783385318 |
| GSE35957 | Up | 0.4552282842 |
| GSE36640 | Up | 1.7308911901 |
| GSE54402 | Up | 0.3946240606 |
| GSE9593 | Down | -0.1729168794 |
| GSE43922 | Up | 0.0943341516 |
| GSE24585 | Up | 0.4898075117 |
| GSE37065 | Down | -0.2133425993 |
| GSE28863_A1 | Up | 0.6063923055 |
| GSE28863_A2 | Up | 0.0797456826 |
| GSE28863_A3 | Up | 0.2058373024 |
| GSE28863_A4 | Down | -0.1476450733 |
| GSE48662 | Down | -0.0707109320 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Dextrothyroxine | DB00509 | APRD00911 |
| Liotrix | DB01583 | - |
| [3,5-Dibromo-4-(4-Hydroxy-3-Phenethylcarbamoyl-Phenoxy)-Phenyl]-Acetic Acid | DB02106 | EXPT00196 |
| 3,5-Dichloro-4-[(4-Hydroxy-3-Isopropylphenoxy)Phenylacetic Acid | DB03176 | EXPT01852 |
| 2-[4-(4-Hydroxy-3-Isopropyl-Phenoxy)-3,5-Dimethyl-Phenyl]-2h-[1,2,4]Triazine-3,5-Dione | DB03181 | EXPT02554 |
| [4-(4-Hydroxy-3-Iodo-Phenoxy)-3,5-Diiodo-Phenyl]-Acetic Acid | DB03604 | EXPT00217 |
| GC-24 | DB03788 | EXPT01522 |
| KB2115 | DB05035 | - |
| MB07811 | DB05192 | - |
| {4-[4-hydroxy-3-(1-methylethyl)benzyl]-3,5-dimethylphenoxy}acetic acid | DB07425 | - |
| 1-(4-HEXYLPHENYL)PROP-2-EN-1-ONE | DB08085 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-27a-3p | MIMAT0000084 | MIRT005425 | Luciferase reporter assay//Northern blot//Western blot | Functional MTI | 21149577 |
| hsa-miR-204-5p | MIMAT0000265 | MIRT005524 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20691260 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 17965546 | Given a large variety of genes regulated by THRs and multiplicity of cellular processes potentially influenced by THRs, we addressed the role of THRB (thyroid hormone receptor beta) in cellular radiosensitivity |
| 17965546 | Wild-type and mutant THRB were overexpressed in several cell lines using an adenovirus-mediated gene delivery and their effects were examined after cell exposure to gamma-rays |
| 17965546 | Wild-type THRB decreased clonogenic survival of the cell lines with low levels of endogenous THRB, retarded their growth and synergized with radiation in decreasing proliferative potential and promoting cellular senescence |
| 17965546 | Mutant THRB produced a radioprotective effect, attenuated radiation-induced growth inhibition and cellular senescence |
| 17965546 | The results suggest that THRB may modulate cellular radiosensitivity and stress-induced senescence |
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