HCSGD entry for THPO
1. General information
| Official gene symbol | THPO |
|---|---|
| Entrez ID | 7066 |
| Gene full name | thrombopoietin |
| Other gene symbols | MGDF MKCSF ML MPLLG THCYT1 TPO |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005125 | Cytokine activity | IEA | molecular_function |
| GO:0005179 | Hormone activity | IEA | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0007275 | Multicellular organismal development | TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008083 | Growth factor activity | TAS | molecular_function |
| GO:0008283 | Cell proliferation | IEA | biological_process |
| GO:0030099 | Myeloid cell differentiation | IEA | biological_process |
| GO:0030168 | Platelet activation | TAS | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5727307435 | 0.9110660043 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0152702965 |
| GSE13712_SHEAR | Down | -0.0482012238 |
| GSE13712_STATIC | Down | -0.1708402690 |
| GSE19018 | Up | 0.0313329857 |
| GSE19899_A1 | Up | 0.0156938753 |
| GSE19899_A2 | Up | 0.1238103701 |
| PubMed_21979375_A1 | Up | 0.0122652636 |
| PubMed_21979375_A2 | Up | 0.0605443016 |
| GSE35957 | Up | 0.1066559208 |
| GSE36640 | Up | 0.0388187007 |
| GSE54402 | Up | 0.0196924772 |
| GSE9593 | Up | 0.0382720232 |
| GSE43922 | Up | 0.0273596387 |
| GSE24585 | Up | 0.0218030915 |
| GSE37065 | Up | 0.0337013982 |
| GSE28863_A1 | Up | 0.0931057824 |
| GSE28863_A2 | Up | 0.3320861178 |
| GSE28863_A3 | Up | 0.3072284134 |
| GSE28863_A4 | Down | -0.0428023206 |
| GSE48662 | Down | -0.0140827558 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022813 | Microarray | Functional MTI (Weak) | 18668037 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20852063 | 68-fold) compared to another cytokine combination (SCF, thrombopoietin, and granulocyte colony-stimulating factor), although the two cytokine combinations had a similar level of total mononucleated cell expansion ( approximately 10% difference) |
| 18491948 | Recently, we reported extensive expansion without cell senescence of cord blood (CB)-derived HSC cocultured with OP9 stromal cells for more than 18 weeks with a single cytokine support using human thrombopoietin (TPO) |
| 18206730 | CD34+ cells were expanded for 3 weeks with stem cell factor, Flt-3/Flk-2 ligand, thrombopoietin, and interleukin-6 |
Entries Per Page
Displaying Page of
