HCSGD entry for THBD
1. General information
| Official gene symbol | THBD |
|---|---|
| Entrez ID | 7056 |
| Gene full name | thrombomodulin |
| Other gene symbols | AHUS6 BDCA3 CD141 THPH12 THRM TM |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004872 | Receptor activity | TAS | molecular_function |
| GO:0004888 | Transmembrane signaling receptor activity | IEA | molecular_function |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0007565 | Female pregnancy | IEA | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0009790 | Embryo development | IEA | biological_process |
| GO:0009986 | Cell surface | IDA | cellular_component |
| GO:0010165 | Response to X-ray | IEA | biological_process |
| GO:0010544 | Negative regulation of platelet activation | TAS | biological_process |
| GO:0030195 | Negative regulation of blood coagulation | TAS | biological_process |
| GO:0030246 | Carbohydrate binding | IEA | molecular_function |
| GO:0032496 | Response to lipopolysaccharide | IEA | biological_process |
| GO:0050900 | Leukocyte migration | TAS | biological_process |
| GO:0051591 | Response to cAMP | IEA | biological_process |
| GO:0051918 | Negative regulation of fibrinolysis | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0000176171 | 0.3162793891 | 0.0146500000 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 3.4555127122 |
| GSE13712_SHEAR | Down | -0.3189540336 |
| GSE13712_STATIC | Down | -1.4196294046 |
| GSE19018 | Down | -0.0274092827 |
| GSE19899_A1 | Up | 1.7666216712 |
| GSE19899_A2 | Up | 6.3348614433 |
| PubMed_21979375_A1 | Up | 6.9453645540 |
| PubMed_21979375_A2 | Up | 6.6237191923 |
| GSE35957 | Up | 0.7108253608 |
| GSE36640 | Up | 0.0161313375 |
| GSE54402 | Up | 3.5491915257 |
| GSE9593 | Down | -0.0805597772 |
| GSE43922 | Up | 2.1914020121 |
| GSE24585 | Down | -0.0523241312 |
| GSE37065 | Up | 0.8641592520 |
| GSE28863_A1 | Down | -0.9685007619 |
| GSE28863_A2 | Up | 1.0628078900 |
| GSE28863_A3 | Up | 0.9132743030 |
| GSE28863_A4 | Up | 0.3520018319 |
| GSE48662 | Down | -1.4759209326 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017044 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024294 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026159 | Microarray | Functional MTI (Weak) | 19074876 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
