HCSGD entry for TGFBR3

1. General information

Official gene symbolTGFBR3
Entrez ID7049
Gene full nametransforming growth factor, beta receptor III
Other gene symbolsBGCAN betaglycan
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001568Blood vessel developmentIEAbiological_process
GO:0001666Response to hypoxiaIEAbiological_process
GO:0001824Blastocyst developmentIEAbiological_process
GO:0001837Epithelial to mesenchymal transitionIDAbiological_process
GO:0001889Liver developmentIEA ISSbiological_process
GO:0003007Heart morphogenesisISSbiological_process
GO:0005024Transforming growth factor beta-activated receptor activityIDAmolecular_function
GO:0005114Type II transforming growth factor beta receptor bindingIDAmolecular_function
GO:0005160Transforming growth factor beta receptor bindingIEA ISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005539Glycosaminoglycan bindingISS TASmolecular_function
GO:0005578Proteinaceous extracellular matrixIEAcellular_component
GO:0005615Extracellular spaceIEA TAScellular_component
GO:0005783Endoplasmic reticulumIEAcellular_component
GO:0005887Integral component of plasma membraneIEA ISScellular_component
GO:0006955Immune responseIMPbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayIDA IMPbiological_process
GO:0007181Transforming growth factor beta receptor complex assemblyIEAbiological_process
GO:0008201Heparin bindingIEA ISSmolecular_function
GO:0009897External side of plasma membraneIDAcellular_component
GO:0009986Cell surfaceIEA ISScellular_component
GO:0010633Negative regulation of epithelial cell migrationIEAbiological_process
GO:0010719Negative regulation of epithelial to mesenchymal transitionIEAbiological_process
GO:0015026Coreceptor activityIDAmolecular_function
GO:0016049Cell growthIEA ISSbiological_process
GO:0016477Cell migrationISSbiological_process
GO:0017134Fibroblast growth factor bindingIEAmolecular_function
GO:0030165PDZ domain bindingIEA ISSmolecular_function
GO:0030509BMP signaling pathwayIDAbiological_process
GO:0030511Positive regulation of transforming growth factor beta receptor signaling pathwayIEAbiological_process
GO:0030512Negative regulation of transforming growth factor beta receptor signaling pathwayIEAbiological_process
GO:0031100Organ regenerationIEAbiological_process
GO:0032354Response to follicle-stimulating hormoneIDAbiological_process
GO:0034673Inhibin-betaglycan-ActRII complexIDAcellular_component
GO:0034695Response to prostaglandin EIDAbiological_process
GO:0034699Response to luteinizing hormoneIDAbiological_process
GO:0035556Intracellular signal transductionIMPbiological_process
GO:0043393Regulation of protein bindingIEAbiological_process
GO:0046332SMAD bindingIEA IMPmolecular_function
GO:0048185Activin bindingIEAmolecular_function
GO:0050431Transforming growth factor beta bindingIDA IEAmolecular_function
GO:0050680Negative regulation of epithelial cell proliferationIEA ISSbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityIEAbiological_process
GO:0051271Negative regulation of cellular component movementIDAbiological_process
GO:0055010Ventricular cardiac muscle tissue morphogenesisIEA ISSbiological_process
GO:0060021Palate developmentIEA ISSbiological_process
GO:0060038Cardiac muscle cell proliferationIEA ISSbiological_process
GO:0060216Definitive hemopoiesisISSbiological_process
GO:0060317Cardiac epithelial to mesenchymal transitionIDAbiological_process
GO:0060318Definitive erythrocyte differentiationIEA ISSbiological_process
GO:0060347Heart trabecula formationIEA ISSbiological_process
GO:0060389Pathway-restricted SMAD protein phosphorylationIEA IMPbiological_process
GO:0070123Transforming growth factor beta receptor activity, type IIIIDA IEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.08886098930.00278044530.62504278460.1051495690

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.4317527106
GSE13712_SHEARDown-0.6213828234
GSE13712_STATICDown-0.8721898985
GSE19018Up0.2462950149
GSE19899_A1Down-0.4647859776
GSE19899_A2Down-1.8304939360
PubMed_21979375_A1Down-1.2698682410
PubMed_21979375_A2Down-1.0804687869
GSE35957Down-0.4623721926
GSE36640Down-1.0669039970
GSE54402Down-2.4406842211
GSE9593Up0.4170326651
GSE43922Down-0.9585840576
GSE24585Up0.3697398735
GSE37065Up0.0707928572
GSE28863_A1Up1.3041774425
GSE28863_A2Up1.4599690970
GSE28863_A3Up0.5499590820
GSE28863_A4Down-0.2316921850
GSE48662Down-0.6546692768

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-21-5pMIMAT0000076MIRT005330Luciferase reporter assay//qRT-PCRFunctional MTI18829576
hsa-miR-21-5pMIMAT0000076MIRT005330MicroarrayFunctional MTI (Weak)19253296
hsa-miR-193b-3pMIMAT0002819MIRT016418MicroarrayFunctional MTI (Weak)20304954
hsa-miR-181a-5pMIMAT0000256MIRT025118SequencingFunctional MTI (Weak)20371350
hsa-miR-101-3pMIMAT0000099MIRT027244SequencingFunctional MTI (Weak)20371350
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

15236317The candidate genes PRKCL2 and GTF2B, within SRO2, and TGFBR3, CDC7, and EVI5, in a broad region encompassing SRO3, were screened in 1p22-linked melanoma kindreds, but no coding mutations were detected
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