HCSGD entry for TGFBI
1. General information
| Official gene symbol | TGFBI |
|---|---|
| Entrez ID | 7045 |
| Gene full name | transforming growth factor, beta-induced, 68kDa |
| Other gene symbols | BIGH3 CDB1 CDG2 CDGG1 CSD CSD1 CSD2 CSD3 EBMD LCD1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001525 | Angiogenesis | IEP | biological_process |
| GO:0002062 | Chondrocyte differentiation | IEA | biological_process |
| GO:0005178 | Integrin binding | TAS | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005604 | Basement membrane | IEA | cellular_component |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0007155 | Cell adhesion | IEA | biological_process |
| GO:0007162 | Negative regulation of cell adhesion | TAS | biological_process |
| GO:0007601 | Visual perception | IEA | biological_process |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0030198 | Extracellular matrix organization | IEA | biological_process |
| GO:0031012 | Extracellular matrix | IDA ISS | cellular_component |
| GO:0050840 | Extracellular matrix binding | IEA | molecular_function |
| GO:0050896 | Response to stimulus | IEA | biological_process |
| GO:0070062 | Extracellular vesicular exosome | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2662884883 | 0.2717063751 | 0.9622431768 | 0.9968753136 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0537910430 |
| GSE13712_SHEAR | Up | 0.9383889728 |
| GSE13712_STATIC | Up | 1.2534690860 |
| GSE19018 | Up | 0.3272692728 |
| GSE19899_A1 | Up | 0.2229731837 |
| GSE19899_A2 | Down | -0.3256183557 |
| PubMed_21979375_A1 | Down | -0.6045028847 |
| PubMed_21979375_A2 | Down | -0.0610174303 |
| GSE35957 | Down | -0.3709466650 |
| GSE36640 | Up | 0.0499543058 |
| GSE54402 | Down | -0.1147883404 |
| GSE9593 | Up | 0.1215259543 |
| GSE43922 | Up | 0.1982831462 |
| GSE24585 | Up | 0.0245385238 |
| GSE37065 | Up | 0.0711706269 |
| GSE28863_A1 | Down | -0.2315957673 |
| GSE28863_A2 | Down | -0.0752595381 |
| GSE28863_A3 | Down | -0.0483286073 |
| GSE28863_A4 | Down | -0.4962540190 |
| GSE48662 | Down | -0.1971974079 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | MIRT001208 | Luciferase reporter assay//Western blot | Functional MTI | 19136465 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT001208 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-9-5p | MIMAT0000441 | MIRT006894 | In situ hybridization//Luciferase reporter assay | Functional MTI | 21720722 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028431 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT028995 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031494 | Proteomics | Functional MTI (Weak) | 18668040 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22695319 | The role of TGFBI in mesothelioma and breast cancer: association with tumor suppression |
| 22695319 | BACKGROUND: Transforming growth factor beta induced (TGFBI) product, an extracellular matrix (ECM) protein, has been implicated as a putative tumor suppressor in recent studies |
| 22695319 | Our previous findings revealed that expression of TGFBI gene is down-regulated in a variety of cancer cell lines and clinical tissue samples |
| 22695319 | In this study, ectopic expression of TGFBI was used to ascertain its role as a tumor suppressor and to determine the underlying mechanism of mesothelioma and breast cancer |
| 22695319 | Ectopic expression of TGFBI was quantified by using quantitative PCR and Western-blotting |
| 22695319 | RESULTS: In this study, an ectopic expression of TGFBI in two types of cancer cell lines, a mesothelioma cell line NCI-H28 and a breast cancer cell line MDA-MB-231 was found to have reduced the cellular growth, plating efficiency, and anchorage-independent growth |
| 22695319 | The tumorigenicity of these cancer cell lines as determined by subcutaneous inoculation in nude mice was similarly suppressed by TGFBI expression |
| 22695319 | Likewise, TGFBI expression reduced the proportion of S-phase while increased the proportion of G1 phase in these cells |
| 22695319 | The redistribution of cell cycle phase after re-expression of TGFBI was correspondent with transiently elevated expression of p21 and p53 |
| 22695319 | CONCLUSION: Collectively, these results imply that TGFBI plays a suppressive role in the development of mesothelioma and breast cancer cells, possibly through inhibitions of cell proliferation, delaying of G1-S phase transition, and induction of senescence |
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