HCSGD entry for TGFB2

1. General information

Official gene symbolTGFB2
Entrez ID7042
Gene full nametransforming growth factor, beta 2
Other gene symbolsLDS4 TGF-beta2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000902Cell morphogenesisIDAbiological_process
GO:0001502Cartilage condensationIEAbiological_process
GO:0001525AngiogenesisTASbiological_process
GO:0001540Beta-amyloid bindingIDAmolecular_function
GO:0001654Eye developmentIDAbiological_process
GO:0001666Response to hypoxiaIMPbiological_process
GO:0001837Epithelial to mesenchymal transitionIDA TASbiological_process
GO:0001942Hair follicle developmentIDA ISSbiological_process
GO:0001974Blood vessel remodelingIEAbiological_process
GO:0002576Platelet degranulationTASbiological_process
GO:0003007Heart morphogenesisIDAbiological_process
GO:0004702Receptor signaling protein serine/threonine kinase activityIDAmolecular_function
GO:0005102Receptor bindingIMPmolecular_function
GO:0005114Type II transforming growth factor beta receptor bindingIDA IPImolecular_function
GO:0005125Cytokine activityTASmolecular_function
GO:0005160Transforming growth factor beta receptor bindingIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIDA TAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0006468Protein phosphorylationIDAbiological_process
GO:0007050Cell cycle arrestIDAbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayIDAbiological_process
GO:0007184SMAD protein import into nucleusIDAbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0007411Axon guidanceIEAbiological_process
GO:0007435Salivary gland morphogenesisIEPbiological_process
GO:0007507Heart developmentIDAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008083Growth factor activityIEAmolecular_function
GO:0008219Cell deathIDAbiological_process
GO:0008283Cell proliferationTASbiological_process
GO:0008284Positive regulation of cell proliferationIDAbiological_process
GO:0008285Negative regulation of cell proliferationIDAbiological_process
GO:0008347Glial cell migrationIDAbiological_process
GO:0009611Response to woundingIEPbiological_process
GO:0009790Embryo developmentTASbiological_process
GO:0010002Cardioblast differentiationIDAbiological_process
GO:0010628Positive regulation of gene expressionIEAbiological_process
GO:0010634Positive regulation of epithelial cell migrationIDAbiological_process
GO:0010693Negative regulation of alkaline phosphatase activityIDAbiological_process
GO:0010718Positive regulation of epithelial to mesenchymal transitionIDAbiological_process
GO:0010936Negative regulation of macrophage cytokine productionIDAbiological_process
GO:0014068Positive regulation of phosphatidylinositol 3-kinase signalingIDAbiological_process
GO:0016049Cell growthIEAbiological_process
GO:0016477Cell migrationIDAbiological_process
GO:0022601Menstrual cycle phaseIEPbiological_process
GO:0023014Signal transduction by phosphorylationIDAbiological_process
GO:0030097HemopoiesisISSbiological_process
GO:0030168Platelet activationTASbiological_process
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030199Collagen fibril organizationIDAbiological_process
GO:0030307Positive regulation of cell growthIDAbiological_process
GO:0030308Negative regulation of cell growthIDAbiological_process
GO:0030424AxonISScellular_component
GO:0030593Neutrophil chemotaxisISS TASbiological_process
GO:0031012Extracellular matrixIDAcellular_component
GO:0031069Hair follicle morphogenesisISSbiological_process
GO:0031093Platelet alpha granule lumenTAScellular_component
GO:0032147Activation of protein kinase activityIDAbiological_process
GO:0032570Response to progesteroneIDAbiological_process
GO:0032874Positive regulation of stress-activated MAPK cascadeIDAbiological_process
GO:0032909Regulation of transforming growth factor beta2 productionIMPbiological_process
GO:0033630Positive regulation of cell adhesion mediated by integrinIDAbiological_process
GO:0035556Intracellular signal transductionIDAbiological_process
GO:0042060Wound healingISSbiological_process
GO:0042416Dopamine biosynthetic processISSbiological_process
GO:0042476OdontogenesisNASbiological_process
GO:0042493Response to drugIDAbiological_process
GO:0042637CatagenIDAbiological_process
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0043025Neuronal cell bodyISScellular_component
GO:0043525Positive regulation of neuron apoptotic processIDAbiological_process
GO:0045216Cell-cell junction organizationIDAbiological_process
GO:0045726Positive regulation of integrin biosynthetic processIDAbiological_process
GO:0045778Positive regulation of ossificationIEPbiological_process
GO:0045787Positive regulation of cell cycleISSbiological_process
GO:0045823Positive regulation of heart contractionIDAbiological_process
GO:0046982Protein heterodimerization activityTASmolecular_function
GO:0048103Somatic stem cell divisionISSbiological_process
GO:0048566Embryonic digestive tract developmentIEPbiological_process
GO:0048663Neuron fate commitmentIEAbiological_process
GO:0048666Neuron developmentISSbiological_process
GO:0048699Generation of neuronsTASbiological_process
GO:0050680Negative regulation of epithelial cell proliferationIDA IMPbiological_process
GO:0050714Positive regulation of protein secretionIDAbiological_process
GO:0050777Negative regulation of immune responseTASbiological_process
GO:0050778Positive regulation of immune responseISSbiological_process
GO:0051781Positive regulation of cell divisionIEAbiological_process
GO:0051795Positive regulation of catagenIDAbiological_process
GO:0051891Positive regulation of cardioblast differentiationIDAbiological_process
GO:0060038Cardiac muscle cell proliferationIDAbiological_process
GO:0060317Cardiac epithelial to mesenchymal transitionIDAbiological_process
GO:0060325Face morphogenesisIEAbiological_process
GO:0060389Pathway-restricted SMAD protein phosphorylationIDAbiological_process
GO:0070237Positive regulation of activation-induced cell death of T cellsIEAbiological_process
GO:0097191Extrinsic apoptotic signaling pathwayIDAbiological_process
GO:2001241Positive regulation of extrinsic apoptotic signaling pathway in absence of ligandIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00376921090.04649028150.16452636820.4043855585

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-1.2476110732
GSE13712_SHEARUp0.2074883204
GSE13712_STATICUp1.3282463095
GSE19018Up1.0020079690
GSE19899_A1Down-0.2173644540
GSE19899_A2Up0.9755367410
PubMed_21979375_A1Up0.9191927137
PubMed_21979375_A2Up1.6828795681
GSE35957Down-1.6837117975
GSE36640Up2.9272439279
GSE54402Down-1.7909806136
GSE9593Down-0.2764906472
GSE43922Down-0.0594530073
GSE24585Down-1.0372873149
GSE37065Up0.0200737844
GSE28863_A1Up0.3112142658
GSE28863_A2Up1.0530618708
GSE28863_A3Up0.3855793251
GSE28863_A4Up0.0319229601
GSE48662Up0.4572965851

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-141-3pMIMAT0000432MIRT002285Immunoblot//Luciferase reporter assay//qRT-PCRFunctional MTI18483486
hsa-miR-335-5pMIMAT0000765MIRT017363MicroarrayFunctional MTI (Weak)18185580
hsa-miR-375MIMAT0000728MIRT019708MicroarrayFunctional MTI (Weak)20215506
hsa-miR-21-5pMIMAT0000076MIRT030844MicroarrayFunctional MTI (Weak)18591254
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-141-3pMIMAT00004321hsa-miR-141{Western blot}{overexpression by miRNA precursor transfection}18483486
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 6 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23358854Keratinocytes from GU-OSCC produced high levels of reactive oxygen species (ROS) and this was associated with an increase in the production of transforming growth factor-beta1 (TGF-beta1) and TGF-beta2 in stromal fibroblasts
20554622Transforming growth factor (TGF)-beta2 is thought to be involved in the pathologic changes of the trabecular meshwork (TM) of POAG eyes
20554622The goal of this study was to determine whether TGF-beta2 triggers senescence-associated changes in human TM cells in vitro
20554622Lipid peroxidation was assessed after TGF-beta2 treatment
20554622RESULTS: TGF-beta2 increased SA-beta-Gal activity, lipid peroxidation, and the mRNA expressions of Apo J, SM22, and SPARC
20554622TGF-beta2 increased p16 mRNA and protein expression, which was paralleled by a downregulation of pRb protein
20554622There was no effect on p21 mRNA and protein expression after exposure to TGF-beta2
20554622CONCLUSIONS: TGF-beta2 induces senescence-associated TM changes and activates the senescence-related p16-pRb signal transduction pathway in vitro
20554622Thus, minimizing TGF-beta2 levels may help to prevent the ageing process in the TM as seen in POAG
20551174Lymphomas that arise express high amounts of transforming growth factor beta-2 (TGFbeta-2) and TGFbeta-3
19171648CONCLUSIONS: Oxidative stress, TGF-beta1, and TGF-beta2 are capable of inducing cellular senescence in cultured human RPE cells
17532297FGF-2 suppresses cellular senescence of human mesenchymal stem cells by down-regulation of TGF-beta2
17532297Furthermore, the levels of TGF-betas mRNA expression in hMSCs were increased by long-term culture, but FGF-2 suppressed the increase of TGF-beta2 mRNA expression due to long-term culture
17532297These results suggest that FGF-2 suppresses the hMSCs cellular senescence dependent on the length of culture through down-regulation of TGF-beta2 expression
17473528The mRNA expressions of TGFbeta1, TGFbeta2, and TGFbeta receptor type I (TGFbetaRI) in hMSCs increased with the length of cell culture
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