HCSGD entry for TGFA

1. General information

Official gene symbolTGFA
Entrez ID7039
Gene full nametransforming growth factor, alpha
Other gene symbolsTFGA
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000165MAPK cascadeIDAbiological_process
GO:0000187Activation of MAPK activityIDAbiological_process
GO:0001525AngiogenesisIEAbiological_process
GO:0001948Glycoprotein bindingIEAmolecular_function
GO:0004708MAP kinase kinase activityIDAmolecular_function
GO:0005154Epidermal growth factor receptor bindingIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005615Extracellular spaceIDAcellular_component
GO:0005634NucleusIEAcellular_component
GO:0005886Plasma membraneNAScellular_component
GO:0006468Protein phosphorylationIDAbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayIEAbiological_process
GO:0008083Growth factor activityIDAmolecular_function
GO:0008152Metabolic processIDAbiological_process
GO:0008283Cell proliferationTASbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0016310PhosphorylationIDAbiological_process
GO:0016323Basolateral plasma membraneIDAcellular_component
GO:0031410Cytoplasmic vesicleIDAcellular_component
GO:0042060Wound healingIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0045741Positive regulation of epidermal growth factor-activated receptor activityIDAbiological_process
GO:0045840Positive regulation of mitosisIDAbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0050679Positive regulation of epithelial cell proliferationIDAbiological_process
GO:0051781Positive regulation of cell divisionIEAbiological_process
GO:0060749Mammary gland alveolus developmentIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.04925725090.96771610880.48826498131.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.5285817182
GSE13712_SHEARDown-0.0433444251
GSE13712_STATICUp0.0678636530
GSE19018Up0.1557099417
GSE19899_A1Up0.1039870576
GSE19899_A2Up0.9518687496
PubMed_21979375_A1Up0.9943691899
PubMed_21979375_A2Up0.3043185052
GSE35957Down-0.0774514197
GSE36640Up0.2981388551
GSE54402Up0.6075522254
GSE9593Down-0.0738254464
GSE43922Up0.0175969219
GSE24585Up0.3375965165
GSE37065Up0.0014860211
GSE28863_A1Down-0.3216558038
GSE28863_A2Up0.0445643034
GSE28863_A3Up0.1636551769
GSE28863_A4Up0.0709731596
GSE48662Up0.0868522402

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-152-3pMIMAT0000438MIRT035552Luciferase reporter assayFunctional MTI23460133
hsa-miR-92a-3pMIMAT0000092MIRT049451CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

12593448The role of epidermal growth factors (EGF) and transforming growth factors (TGF) alpha and beta as autocrine factors in inducing senescence of cultured HMEC cells were also investigated
12593448Supplementation of growth media by TGF-alpha induced significant increase in proliferation of target cells
12593448Addition of epidermal growth factors receptor (EGFR) antibody to cells exposed to media devoid of EGF and media supplemented with TGF-alpha showed marked suppression of proliferation of target cells
12593448The morphologic and phenotypic characteristics of target HMEC cells exposed to TGF-alpha were also found similar to those HMEC cells grown during primary culture, suggesting autocrine production of EGF and TGF-alpha by cultured HMEC cells during primary culture
12593448Exposure of senescent cells to media supplemented with EGF and TGF-alpha could not induce their proliferation
7778920This effect is most likely mediated by cytokines that stimulate keratinocyte growth, such as transforming growth factor alpha
7778920In this study, transforming growth factor alpha gene expression in cultured foreskin keratinocytes from donors varying in age from 2 to 82 years was analyzed semiquantitatively by two separate methods, ie, Northern hybridization and competitive polymerase chain reaction
7778920RESULTS: No pattern of decline in transforming growth factor alpha messenger RNA expression with increasing cellular age was observed by either analysis
7778920CONCLUSION: The results indicate that expression of transforming growth factor alpha by cultured grafts may not be significantly affected by increasing cellular age and suggest that, even in the elderly, cultured autografts may be effective as pharmacologic agents for wound treatment
8504493Autocrine production of TGF-alpha and TGF-beta during tumour progression of rat oral keratinocytes
8504493This study describes a new technique to separate transforming growth factor-alpha (TGF-alpha) and transforming growth factor-beta (TGF-beta) from culture supernatants using ion exchange chromatography; assays of competitive inhibition of ligand binding were used to quantify the amount of growth factor
8504493The autocrine production of TGF-alpha and TGF-beta was examined in oral keratinocyte cell lines derived from the palatal and lingual mucosa of rats painted with the carcinogen 4-nitroquinoline N-oxide (4NQO)
8504493Escape from cellular senescence (immortality) was associated with a marked increase in TGF-alpha production (cell line R2P) but tumour progression, as reflected by the development of anchorage independence in agarose gels and tumorigenicity in athymic mice, did not result in a consistent increase or decrease of TGF-alpha production compared to normals
8504493Four cell lines (R8AP, R1T, R3T, R1P), with different functional cellular phenotypes, produced two to three times more TGF-alpha than normals
8504493TGF-alpha production was inversely correlated to epidermal growth factor cell surface receptor expression
8504493The production of TGF-beta was unrelated to tumour progression, the expression of TGF-beta cell surface receptors or TGF-alpha production
8504493The results indicate that the autocrine production of TGF-alpha and TGF-beta are not accurate markers of tumour progression in the rat 4NQO model of oral carcinogenesis
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