HCSGD entry for TFRC
1. General information
| Official gene symbol | TFRC |
|---|---|
| Entrez ID | 7037 |
| Gene full name | transferrin receptor (p90, CD71) |
| Other gene symbols | CD71 T9 TFR TFR1 TR TRFR p90 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003725 | Double-stranded RNA binding | IDA | molecular_function |
| GO:0004998 | Transferrin receptor activity | NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | IDA | cellular_component |
| GO:0005768 | Endosome | IDA IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0005905 | Coated pit | IDA | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0006879 | Cellular iron ion homeostasis | IEA NAS TAS | biological_process |
| GO:0006898 | Receptor-mediated endocytosis | NAS TAS | biological_process |
| GO:0008233 | Peptidase activity | IEA | molecular_function |
| GO:0009897 | External side of plasma membrane | IEA | cellular_component |
| GO:0016020 | Membrane | NAS | cellular_component |
| GO:0016023 | Cytoplasmic membrane-bounded vesicle | IDA | cellular_component |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0030316 | Osteoclast differentiation | IEA | biological_process |
| GO:0033572 | Transferrin transport | TAS | biological_process |
| GO:0042470 | Melanosome | IEA | cellular_component |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0045780 | Positive regulation of bone resorption | IEA | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
| GO:0070062 | Extracellular vesicular exosome | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3597084229 | 0.1175260248 | 0.9999902473 | 0.6577509037 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1584370440 |
| GSE13712_SHEAR | Down | -0.7672918743 |
| GSE13712_STATIC | Down | -0.2256103114 |
| GSE19018 | Down | -0.2549954527 |
| GSE19899_A1 | Up | 0.0810977837 |
| GSE19899_A2 | Up | 0.1121679166 |
| PubMed_21979375_A1 | Up | 0.3944173121 |
| PubMed_21979375_A2 | Up | 0.1808455223 |
| GSE35957 | Down | -0.2539723723 |
| GSE36640 | Down | -0.0874027158 |
| GSE54402 | Up | 0.1643052161 |
| GSE9593 | Up | 0.2810406921 |
| GSE43922 | Up | 0.5355411272 |
| GSE24585 | Down | -0.4347354382 |
| GSE37065 | Down | -0.0436946116 |
| GSE28863_A1 | Down | -0.0101330853 |
| GSE28863_A2 | Up | 0.6194181948 |
| GSE28863_A3 | Down | -0.3536355890 |
| GSE28863_A4 | Down | -0.1040000845 |
| GSE48662 | Down | -0.7092703210 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-320a | MIMAT0000510 | MIRT003744 | Luciferase reporter assay | Functional MTI | 18523662 |
| hsa-miR-320a | MIMAT0000510 | MIRT003744 | Luciferase reporter assay | Functional MTI | 19164563 |
| hsa-miR-320a | MIMAT0000510 | MIRT003744 | Luciferase reporter assay//Northern blot//flow | Functional MTI | 19135902 |
| hsa-miR-22-3p | MIMAT0000077 | MIRT004538 | Luciferase reporter assay//Northern blot//flow | Functional MTI | 19135902 |
| hsa-miR-200a-3p | MIMAT0000682 | MIRT004549 | Northern blot | Functional MTI (Weak) | 19135902 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025450 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-769-5p | MIMAT0003886 | MIRT039196 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125a-5p | MIMAT0000443 | MIRT045700 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051253 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27579045 | 1, CD44H, CD29, and CD71 and lack of CD11b/c and CD45 markers |
| 16563376 | GTPases of the Rab family control vesicular trafficking, and Rab11 is involved in transferrin receptor recycling |
| 15265523 | Flow cytometric analysis was performed using alpha6 integrin and CD71 antibodies, and candidate keratinocyte stem cell proportions were separated according to reactivities to these antibodies |
| 10764734 | Aged cells presented decreased levels of EGFR, although insulin receptor and transferrin receptor levels were relatively unchanged |
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