HCSGD entry for TFPI
1. General information
| Official gene symbol | TFPI |
|---|---|
| Entrez ID | 7035 |
| Gene full name | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) |
| Other gene symbols | EPI LACI TFI TFPI1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004866 | Endopeptidase inhibitor activity | TAS | molecular_function |
| GO:0004867 | Serine-type endopeptidase inhibitor activity | IEA | molecular_function |
| GO:0005576 | Extracellular region | IEA TAS | cellular_component |
| GO:0005615 | Extracellular space | IDA | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0007596 | Blood coagulation | IEA TAS | biological_process |
| GO:0007598 | Blood coagulation, extrinsic pathway | TAS | biological_process |
| GO:0010951 | Negative regulation of endopeptidase activity | TAS | biological_process |
| GO:0031090 | Organelle membrane | IEA | cellular_component |
| GO:0031225 | Anchored component of membrane | IEA | cellular_component |
| GO:0052548 | Regulation of endopeptidase activity | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0100839368 | 0.2241853615 | 0.2557026012 | 0.9115993975 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 1.4560505795 |
| GSE13712_SHEAR | Down | -1.3238989487 |
| GSE13712_STATIC | Down | -1.1502362994 |
| GSE19018 | Up | 0.5286322932 |
| GSE19899_A1 | Down | -0.6059118428 |
| GSE19899_A2 | Down | -0.0773806349 |
| PubMed_21979375_A1 | Down | -0.0006817543 |
| PubMed_21979375_A2 | Up | 0.0908912768 |
| GSE35957 | Down | -0.7814012942 |
| GSE36640 | Up | 0.3811007770 |
| GSE54402 | Down | -0.6937473551 |
| GSE9593 | Up | 0.5282977112 |
| GSE43922 | Up | 0.1757395085 |
| GSE24585 | Up | 0.3643697231 |
| GSE37065 | Up | 0.8181009236 |
| GSE28863_A1 | Up | 0.3216206611 |
| GSE28863_A2 | Up | 0.7165707797 |
| GSE28863_A3 | Down | -0.4577013152 |
| GSE28863_A4 | Up | 0.5517897734 |
| GSE48662 | Up | 0.7609707205 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Coagulation factor VIIa Recombinant Human | DB00036 | BTD00006 | BIOD00006 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018341 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT020797 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-132-3p | MIMAT0000426 | MIRT021798 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025882 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025882 | Microarray | Functional MTI (Weak) | 19073608 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027730 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031813 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT048954 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
