HCSGD entry for TFAM
1. General information
| Official gene symbol | TFAM |
|---|---|
| Entrez ID | 7019 |
| Gene full name | transcription factor A, mitochondrial |
| Other gene symbols | MTTF1 MTTFA TCF6 TCF6L1 TCF6L2 TCF6L3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003682 | Chromatin binding | IDA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IMP | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005759 | Mitochondrial matrix | TAS | cellular_component |
| GO:0006261 | DNA-dependent DNA replication | TAS | biological_process |
| GO:0006356 | Regulation of transcription from RNA polymerase I promoter | TAS | biological_process |
| GO:0006390 | Transcription from mitochondrial promoter | IMP TAS | biological_process |
| GO:0006391 | Transcription initiation from mitochondrial promoter | IDA TAS | biological_process |
| GO:0008301 | DNA binding, bending | IDA | molecular_function |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0031072 | Heat shock protein binding | IEA | molecular_function |
| GO:0033108 | Mitochondrial respiratory chain complex assembly | IEA | biological_process |
| GO:0042645 | Mitochondrial nucleoid | IDA | cellular_component |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0070363 | Mitochondrial light strand promoter sense binding | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1810998518 | 0.2927822271 | 0.8334520797 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1424376443 |
| GSE13712_SHEAR | Up | 0.0919626507 |
| GSE13712_STATIC | Up | 0.0525568068 |
| GSE19018 | Down | -0.4927621839 |
| GSE19899_A1 | Down | -0.1598622374 |
| GSE19899_A2 | Up | 0.0017256616 |
| PubMed_21979375_A1 | Up | 0.6471789866 |
| PubMed_21979375_A2 | Down | -0.0216536446 |
| GSE35957 | Down | -0.5436878139 |
| GSE36640 | Down | -1.4589652714 |
| GSE54402 | Up | 0.4837575224 |
| GSE9593 | Down | -0.5477848081 |
| GSE43922 | Up | 0.1570254040 |
| GSE24585 | Down | -0.3325241231 |
| GSE37065 | Up | 0.3823512453 |
| GSE28863_A1 | Up | 0.3952565685 |
| GSE28863_A2 | Up | 0.4273347027 |
| GSE28863_A3 | Down | -0.1242509140 |
| GSE28863_A4 | Up | 0.2034459569 |
| GSE48662 | Up | 0.0731684477 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-15a-3p | MIMAT0004488 | MIRT038986 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041703 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT047391 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049528 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-26a-5p | MIMAT0000082 | MIRT050062 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24264057 | Furthermore, upon muscle contraction, p53 is phosphorylated on serine 15 and subsequently translocates to the mitochondria where it forms a complex with Tfam to modulate expression of mitochondrial-encoded subunits of the COX complex |
| 23159434 | Furthermore, the overexpression of PGC-1alpha induced by transfection largely increased the expression levels of NRF-1 and TFAM and significantly decreased the expression level of NF-kappaB in the cell senescence model |
| 22129993 | To synthetically generate glycolytic fibroblasts, we genetically-induced mitochondrial dysfunction by knocking down TFAM using an sh-RNA approach |
| 22129993 | TFAM is mitochondrial transcription factor A, which is important in functionally maintaining the mitochondrial respiratory chain |
| 18326800 | In aged vessels, the expression of the mitochondrial biogenesis factors (including mitochondrial transcription factor A and peroxisome proliferator-activated receptor-gamma coactivator-1) was decreased |
| 10603304 | The expression of both mtDNA (by mtTFA) and nDNA for oxphos and UCP (by NRFs, etc |
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