HCSGD entry for TF
1. General information
| Official gene symbol | TF |
|---|---|
| Entrez ID | 7018 |
| Gene full name | transferrin |
| Other gene symbols | PRO1557 PRO2086 TFQTL1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002576 | Platelet degranulation | TAS | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | IEA NAS TAS | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005769 | Early endosome | IDA | cellular_component |
| GO:0005770 | Late endosome | IDA | cellular_component |
| GO:0005905 | Coated pit | IDA | cellular_component |
| GO:0006826 | Iron ion transport | IEA | biological_process |
| GO:0006879 | Cellular iron ion homeostasis | IEA TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008199 | Ferric iron binding | IEA | molecular_function |
| GO:0009925 | Basal plasma membrane | IDA | cellular_component |
| GO:0010008 | Endosome membrane | TAS | cellular_component |
| GO:0016023 | Cytoplasmic membrane-bounded vesicle | IDA | cellular_component |
| GO:0016324 | Apical plasma membrane | IDA | cellular_component |
| GO:0030139 | Endocytic vesicle | IDA | cellular_component |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0031625 | Ubiquitin protein ligase binding | IEA | molecular_function |
| GO:0033572 | Transferrin transport | TAS | biological_process |
| GO:0034774 | Secretory granule lumen | TAS | cellular_component |
| GO:0045178 | Basal part of cell | IDA | cellular_component |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0055037 | Recycling endosome | IDA | cellular_component |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3394662399 | 0.7535651799 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0495068982 |
| GSE13712_SHEAR | Down | -0.0584255960 |
| GSE13712_STATIC | Down | -0.0904522461 |
| GSE19018 | Up | 0.1445276497 |
| GSE19899_A1 | Up | 0.0168564344 |
| GSE19899_A2 | Down | -0.0800279482 |
| PubMed_21979375_A1 | Down | -0.2380525137 |
| PubMed_21979375_A2 | Down | -0.0089093746 |
| GSE35957 | Up | 0.0848586761 |
| GSE36640 | Up | 0.2207157495 |
| GSE54402 | Down | -0.0459794432 |
| GSE9593 | Down | -0.9091590319 |
| GSE43922 | Up | 0.1843844638 |
| GSE24585 | Up | 0.2543814206 |
| GSE37065 | Down | -0.0111187953 |
| GSE28863_A1 | Up | 0.2562967408 |
| GSE28863_A2 | Up | 0.3744835211 |
| GSE28863_A3 | Up | 0.1125520023 |
| GSE28863_A4 | Up | 0.3581694386 |
| GSE48662 | Down | -0.0337382823 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Aluminium | DB01370 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018601 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 7 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 16563376 | GTPases of the Rab family control vesicular trafficking, and Rab11 is involved in transferrin receptor recycling |
| 16300485 | This is correlated with a generally decreased endocytotic activity of these cells, as shown with the model substrate transferrin |
| 11909691 | Iron, to be redox cycling active, has to be released from its macromolecular complexes (ferritin, transferrin, hemoproteins, etc |
| 10764734 | Aged cells presented decreased levels of EGFR, although insulin receptor and transferrin receptor levels were relatively unchanged |
| 8547717 | In particular, we hypothesize that oxidative imbalance could lead to an impairment of the expression of these receptors, such as transferrin receptors, via a modification of the cytoskeleton |
| 8513512 | Transfected T cells of both young and elderly subjects appear to display normal T cell function: they cease doubling upon removal of IL-2; in the presence of autologous adherent mononuclear cells they respond to mitogen stimulation and produce IL-2 and IFN-gamma during proliferation; and they express both IL-2 and transferrin receptors similar to those observed in mitogen-stimulated nontransfected T cells |
| 3759796 | Serum growth factors to which the arterial endothelial cells responded included insulin, transferrin, epidermal growth factor, thrombin, and somatomedins |
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