HCSGD entry for TEP1
1. General information
| Official gene symbol | TEP1 |
|---|---|
| Entrez ID | 7011 |
| Gene full name | telomerase-associated protein 1 |
| Other gene symbols | TLP1 TP1 TROVE1 VAULT2 p240 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000722 | Telomere maintenance via recombination | IDA | biological_process |
| GO:0000781 | Chromosome, telomeric region | IEA | cellular_component |
| GO:0003720 | Telomerase activity | IDA | molecular_function |
| GO:0003723 | RNA binding | IEA ISS | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005697 | Telomerase holoenzyme complex | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006278 | RNA-dependent DNA replication | IDA | biological_process |
| GO:0016363 | Nuclear matrix | IDA | cellular_component |
| GO:0030529 | Ribonucleoprotein complex | IEA TAS | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2504354090 | 0.4850624140 | 0.9401954643 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2740581826 |
| GSE13712_SHEAR | Up | 0.1258727757 |
| GSE13712_STATIC | Up | 0.1946328317 |
| GSE19018 | Down | -0.0879847607 |
| GSE19899_A1 | Down | -0.2260209828 |
| GSE19899_A2 | Down | -0.2129835262 |
| PubMed_21979375_A1 | Down | -0.2769192169 |
| PubMed_21979375_A2 | Down | -0.4252563108 |
| GSE35957 | Up | 0.2113537853 |
| GSE36640 | Up | 0.1097591771 |
| GSE54402 | Down | -0.2225916411 |
| GSE9593 | Up | 0.1712063000 |
| GSE43922 | Up | 0.0514882553 |
| GSE24585 | Up | 0.4643176630 |
| GSE37065 | Up | 0.0238378780 |
| GSE28863_A1 | Up | 0.2966574390 |
| GSE28863_A2 | Up | 0.4764069224 |
| GSE28863_A3 | Down | -0.2262796316 |
| GSE28863_A4 | Down | -0.0470168416 |
| GSE48662 | Down | -0.0897820368 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-484 | MIMAT0002174 | MIRT042181 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051249 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 11531263 | Recently, a number of relevant genes have been cloned, including these encoding three major components of human telomerase: human telomerase RNA component (hTR), human telomerase reverse transcriptase (hTERT), and telomerase-associated protein-1 (TEP1) |
| 11481865 | They included those for human telomerase RNA component (hTR), human telomerase reverse transcriptase (hTERT), and telomerase-associated protein 1 (TEP1) |
| 11481865 | They included those for human telomerase RNA component (hTR), human telomerase reverse transcriptase (hTERT), and telomerase-associated protein 1 (TEP1) |
| 11123427 | Recently several relevant genes have been cloned, including those encoding three major components of human telomerase: human telomerase RNA component (hTR), human telomerase reverse transcriptase (hTERT), and telomerase-associated protein-1 (TEP1) |
| 11123427 | In all 10 malignant cell lines with telomerase activity, hTR, hTERT mRNA, and TEP1 mRNA were expressed, while in normal monocytes and granulocytes without telomerase activity, expression of hTR, but not hTERT mRNA was detected |
| 11123427 | TEP1 mRNA was expressed in normal monocytes, but not granulocytes |
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