HCSGD entry for TEK
1. General information
| Official gene symbol | TEK |
|---|---|
| Entrez ID | 7010 |
| Gene full name | TEK tyrosine kinase, endothelial |
| Other gene symbols | CD202B TIE-2 TIE2 VMCM VMCM1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001525 | Angiogenesis | ISS | biological_process |
| GO:0001666 | Response to hypoxia | IEA | biological_process |
| GO:0001725 | Stress fiber | IDA | cellular_component |
| GO:0001934 | Positive regulation of protein phosphorylation | IDA IMP | biological_process |
| GO:0001935 | Endothelial cell proliferation | ISS | biological_process |
| GO:0001938 | Positive regulation of endothelial cell proliferation | TAS | biological_process |
| GO:0001958 | Endochondral ossification | IEA | biological_process |
| GO:0002040 | Sprouting angiogenesis | IMP | biological_process |
| GO:0004672 | Protein kinase activity | TAS | molecular_function |
| GO:0004713 | Protein tyrosine kinase activity | IDA TAS | molecular_function |
| GO:0004714 | Transmembrane receptor protein tyrosine kinase activity | IEA | molecular_function |
| GO:0004872 | Receptor activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005884 | Actin filament | IDA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | IDA | cellular_component |
| GO:0005902 | Microvillus | IDA | cellular_component |
| GO:0005911 | Cell-cell junction | IDA | cellular_component |
| GO:0005925 | Focal adhesion | IEA | cellular_component |
| GO:0007160 | Cell-matrix adhesion | IEA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007169 | Transmembrane receptor protein tyrosine kinase signaling pathway | IDA | biological_process |
| GO:0007267 | Cell-cell signaling | TAS | biological_process |
| GO:0007507 | Heart development | ISS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0009925 | Basal plasma membrane | IDA | cellular_component |
| GO:0009986 | Cell surface | IDA | cellular_component |
| GO:0010595 | Positive regulation of endothelial cell migration | IDA IMP | biological_process |
| GO:0014068 | Positive regulation of phosphatidylinositol 3-kinase signaling | IMP | biological_process |
| GO:0016323 | Basolateral plasma membrane | IDA | cellular_component |
| GO:0016324 | Apical plasma membrane | IDA | cellular_component |
| GO:0016337 | Cell-cell adhesion | IEA | biological_process |
| GO:0016525 | Negative regulation of angiogenesis | IMP | biological_process |
| GO:0018108 | Peptidyl-tyrosine phosphorylation | IDA | biological_process |
| GO:0019838 | Growth factor binding | IEA | molecular_function |
| GO:0031100 | Organ regeneration | IEA | biological_process |
| GO:0032878 | Regulation of establishment or maintenance of cell polarity | IMP | biological_process |
| GO:0033138 | Positive regulation of peptidyl-serine phosphorylation | IEA | biological_process |
| GO:0034446 | Substrate adhesion-dependent cell spreading | IMP | biological_process |
| GO:0035556 | Intracellular signal transduction | IEA | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | TAS | biological_process |
| GO:0043114 | Regulation of vascular permeability | TAS | biological_process |
| GO:0043434 | Response to peptide hormone | IEA | biological_process |
| GO:0043552 | Positive regulation of phosphatidylinositol 3-kinase activity | IMP | biological_process |
| GO:0043627 | Response to estrogen | IEA | biological_process |
| GO:0045121 | Membrane raft | IDA | cellular_component |
| GO:0045766 | Positive regulation of angiogenesis | IDA IMP | biological_process |
| GO:0046777 | Protein autophosphorylation | IDA | biological_process |
| GO:0048014 | Tie signaling pathway | IDA | biological_process |
| GO:0050728 | Negative regulation of inflammatory response | TAS | biological_process |
| GO:0050900 | Leukocyte migration | TAS | biological_process |
| GO:0051259 | Protein oligomerization | IDA | biological_process |
| GO:0051591 | Response to cAMP | IEA | biological_process |
| GO:0051894 | Positive regulation of focal adhesion assembly | IMP | biological_process |
| GO:0051897 | Positive regulation of protein kinase B signaling | IDA IMP | biological_process |
| GO:0060216 | Definitive hemopoiesis | TAS | biological_process |
| GO:0060347 | Heart trabecula formation | ISS | biological_process |
| GO:0070374 | Positive regulation of ERK1 and ERK2 cascade | IDA IMP | biological_process |
| GO:1902533 | Positive regulation of intracellular signal transduction | IMP | biological_process |
| GO:2000251 | Positive regulation of actin cytoskeleton reorganization | IMP | biological_process |
| GO:2000351 | Regulation of endothelial cell apoptotic process | TAS | biological_process |
| GO:2000352 | Negative regulation of endothelial cell apoptotic process | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3522463280 | 0.0091450933 | 0.9999902473 | 0.1887905882 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.6159556505 |
| GSE13712_SHEAR | Down | -0.2852666185 |
| GSE13712_STATIC | Down | -0.1768366888 |
| GSE19018 | Down | -0.2440743895 |
| GSE19899_A1 | Down | -0.7312284560 |
| GSE19899_A2 | Down | -1.0132754243 |
| PubMed_21979375_A1 | Down | -0.8947904352 |
| PubMed_21979375_A2 | Down | -0.4819464329 |
| GSE35957 | Up | 0.5187887287 |
| GSE36640 | Down | -0.1818364075 |
| GSE54402 | Down | -2.0938960321 |
| GSE9593 | Up | 0.0162951311 |
| GSE43922 | Up | 0.0540550295 |
| GSE24585 | Down | -0.2411186630 |
| GSE37065 | Up | 0.0344158822 |
| GSE28863_A1 | Up | 0.1131174893 |
| GSE28863_A2 | Down | -0.1231430013 |
| GSE28863_A3 | Up | 0.2601193521 |
| GSE28863_A4 | Up | 0.6786796825 |
| GSE48662 | Up | 0.2752594910 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| XL184 | DB05153 | - |
| N-{4-METHYL-3-[(3-PYRIMIDIN-4-YLPYRIDIN-2-YL)AMINO]PHENYL}-3-(TRIFLUOROMETHYL)BENZAMIDE | DB08221 | - |
| Regorafenib | DB08896 | - |
| Ponatinib | DB08901 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-126-3p | MIMAT0000445 | MIRT006883 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 22867989 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21730299 | Cellular senescence impaired angiogenic functions in ECs without attenuating the mitogen-activated protein kinase or Akt signaling, and vascular endothelial growth factor receptor 2 or Tie-2 expressions |
| 20453494 | Angiopoietin-1 inhibits mouse glomerular endothelial cell senescence via Tie2 receptor-modulated ERK1/2 signaling |
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