HCSGD entry for ACTC1
1. General information
| Official gene symbol | ACTC1 |
|---|---|
| Entrez ID | 70 |
| Gene full name | actin, alpha, cardiac muscle 1 |
| Other gene symbols | ACTC ASD5 CMD1R CMH11 LVNC4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005524 | ATP binding | IDA | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005884 | Actin filament | IDA | cellular_component |
| GO:0006200 | ATP catabolic process | IDA | biological_process |
| GO:0006915 | Apoptotic process | ISS | biological_process |
| GO:0008152 | Metabolic process | IDA | biological_process |
| GO:0016887 | ATPase activity | IDA | molecular_function |
| GO:0017022 | Myosin binding | IDA IPI | molecular_function |
| GO:0030017 | Sarcomere | IDA | cellular_component |
| GO:0030048 | Actin filament-based movement | IDA | biological_process |
| GO:0030049 | Muscle filament sliding | TAS | biological_process |
| GO:0030240 | Skeletal muscle thin filament assembly | ISS | biological_process |
| GO:0031032 | Actomyosin structure organization | ISS | biological_process |
| GO:0031674 | I band | ISS | cellular_component |
| GO:0033275 | Actin-myosin filament sliding | IMP | biological_process |
| GO:0042493 | Response to drug | IEA | biological_process |
| GO:0042643 | Actomyosin, actin portion | IDA | cellular_component |
| GO:0043066 | Negative regulation of apoptotic process | IEA | biological_process |
| GO:0045471 | Response to ethanol | IEA | biological_process |
| GO:0055003 | Cardiac myofibril assembly | ISS | biological_process |
| GO:0055008 | Cardiac muscle tissue morphogenesis | ISS | biological_process |
| GO:0060047 | Heart contraction | IMP | biological_process |
| GO:0060048 | Cardiac muscle contraction | IEA | biological_process |
| GO:0070062 | Extracellular vesicular exosome | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7471161924 | 0.0060387067 | 0.9999902473 | 0.1575897919 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.6500189296 |
| GSE13712_SHEAR | Up | 0.2006554911 |
| GSE13712_STATIC | Down | -0.0789923565 |
| GSE19018 | Down | -1.2239222734 |
| GSE19899_A1 | Down | -0.2226661674 |
| GSE19899_A2 | Down | -1.6960916667 |
| PubMed_21979375_A1 | Down | -0.4993517372 |
| PubMed_21979375_A2 | Down | -1.3678791257 |
| GSE35957 | Up | 1.6871509586 |
| GSE36640 | Up | 0.8361119775 |
| GSE54402 | Down | -0.0799530015 |
| GSE9593 | Down | -0.2234376123 |
| GSE43922 | Down | -0.1397031512 |
| GSE24585 | Down | -0.1051899293 |
| GSE37065 | Up | 0.6047839335 |
| GSE28863_A1 | Down | -0.5039400858 |
| GSE28863_A2 | Down | -1.3827698190 |
| GSE28863_A3 | Up | 0.0143355112 |
| GSE28863_A4 | Up | 0.0791804930 |
| GSE48662 | Up | 0.0241732210 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT023839 | Proteomics | Functional MTI (Weak) | 18668040 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
