HCSGD entry for TCF21

1. General information

Official gene symbolTCF21
Entrez ID6943
Gene full nametranscription factor 21
Other gene symbolsPOD1 bHLHa23
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionISSmolecular_function
GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptionIDAmolecular_function
GO:0001657Ureteric bud developmentISSbiological_process
GO:0001658Branching involved in ureteric bud morphogenesisISSbiological_process
GO:0001763Morphogenesis of a branching structureISSbiological_process
GO:0001822Kidney developmentISSbiological_process
GO:0001944Vasculature developmentISSbiological_process
GO:0005634NucleusIDAcellular_component
GO:0006366Transcription from RNA polymerase II promoterIDA ISSbiological_process
GO:0007530Sex determinationISSbiological_process
GO:0014707Branchiomeric skeletal muscle developmentISSbiological_process
GO:0030855Epithelial cell differentiationISSbiological_process
GO:0032835Glomerulus developmentISSbiological_process
GO:0042826Histone deacetylase bindingIEAmolecular_function
GO:0043425BHLH transcription factor bindingIPImolecular_function
GO:0045944Positive regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0046983Protein dimerization activityISSmolecular_function
GO:0048286Lung alveolus developmentISSbiological_process
GO:0048536Spleen developmentISSbiological_process
GO:0048557Embryonic digestive tract morphogenesisISSbiological_process
GO:0048608Reproductive structure developmentISSbiological_process
GO:0048732Gland developmentISSbiological_process
GO:0050681Androgen receptor bindingISSmolecular_function
GO:0060008Sertoli cell differentiationISSbiological_process
GO:0060021Palate developmentISSbiological_process
GO:0060425Lung morphogenesisISSbiological_process
GO:0060426Lung vasculature developmentISSbiological_process
GO:0060435Bronchiole developmentISSbiological_process
GO:0060539Diaphragm developmentISSbiological_process
GO:0060541Respiratory system developmentISSbiological_process
GO:0060766Negative regulation of androgen receptor signaling pathwayISSbiological_process
GO:0070888E-box bindingISSmolecular_function
GO:0072162Metanephric mesenchymal cell differentiationISSbiological_process
GO:0072277Metanephric glomerular capillary formationISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.65486635010.00707970440.99999024730.1677271827

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0446063506
GSE13712_SHEARDown-0.0227766547
GSE13712_STATICDown-0.0664779245
GSE19018Up0.3162205910
GSE19899_A1Down-2.1397937711
GSE19899_A2Down-1.1758530403
PubMed_21979375_A1Down-1.4655715833
PubMed_21979375_A2Down-1.7043589290
GSE35957Up0.0923143318
GSE36640Up0.6224964791
GSE54402Down-3.6487142523
GSE9593Up0.0147428200
GSE43922Down-0.8779701925
GSE24585Down-0.0304960835
GSE37065Down-0.1946527506
GSE28863_A1Down-0.0142571150
GSE28863_A2Up0.0644451425
GSE28863_A3Up0.2022154970
GSE28863_A4Up0.3613963673
GSE48662Down-0.0182672184

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-21-5pMIMAT0000076MIRT007085Luciferase reporter assayFunctional MTI23206776
hsa-miR-181a-5pMIMAT0000256MIRT025053MicroarrayFunctional MTI (Weak)17612493
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.