HCSGD entry for ZEB1
1. General information
| Official gene symbol | ZEB1 |
|---|---|
| Entrez ID | 6935 |
| Gene full name | zinc finger E-box binding homeobox 1 |
| Other gene symbols | AREB6 BZP DELTAEF1 FECD6 NIL2A PPCD3 TCF8 ZFHEP ZFHX1A |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0003690 | Double-stranded DNA binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0003713 | Transcription coactivator activity | TAS | molecular_function |
| GO:0003714 | Transcription corepressor activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005667 | Transcription factor complex | IEA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006955 | Immune response | TAS | biological_process |
| GO:0007389 | Pattern specification process | IEA | biological_process |
| GO:0008134 | Transcription factor binding | IEA | molecular_function |
| GO:0008270 | Zinc ion binding | TAS | molecular_function |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | IEA | biological_process |
| GO:0010464 | Regulation of mesenchymal cell proliferation | IEA | biological_process |
| GO:0014823 | Response to activity | IEA | biological_process |
| GO:0017015 | Regulation of transforming growth factor beta receptor signaling pathway | IEA | biological_process |
| GO:0030857 | Negative regulation of epithelial cell differentiation | IEA | biological_process |
| GO:0030900 | Forebrain development | IEA | biological_process |
| GO:0031667 | Response to nutrient levels | IEA | biological_process |
| GO:0033081 | Regulation of T cell differentiation in thymus | IEA | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0045666 | Positive regulation of neuron differentiation | IEA ISS | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IDA IMP | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048596 | Embryonic camera-type eye morphogenesis | IEA | biological_process |
| GO:0048704 | Embryonic skeletal system morphogenesis | IEA | biological_process |
| GO:0048752 | Semicircular canal morphogenesis | IEA | biological_process |
| GO:0051150 | Regulation of smooth muscle cell differentiation | IEA | biological_process |
| GO:0051216 | Cartilage development | IEA | biological_process |
| GO:0070888 | E-box binding | IEA ISS | molecular_function |
| GO:0071230 | Cellular response to amino acid stimulus | IEA | biological_process |
| GO:0071560 | Cellular response to transforming growth factor beta stimulus | IEA | biological_process |
| GO:0090103 | Cochlea morphogenesis | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0577073971 | 0.6387914821 | 0.5208685293 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3095617635 |
| GSE13712_SHEAR | Up | 0.0736009500 |
| GSE13712_STATIC | Down | -0.0867627367 |
| GSE19018 | Down | -0.2547360273 |
| GSE19899_A1 | Up | 0.1924421028 |
| GSE19899_A2 | Down | -0.4330016191 |
| PubMed_21979375_A1 | Up | 0.6704332271 |
| PubMed_21979375_A2 | Up | 0.6331791793 |
| GSE35957 | Up | 0.2950850312 |
| GSE36640 | Up | 0.6326419870 |
| GSE54402 | Up | 0.4733915395 |
| GSE9593 | Up | 0.1406287734 |
| GSE43922 | Up | 0.1034917901 |
| GSE24585 | Down | -0.1519946637 |
| GSE37065 | Up | 0.1420783696 |
| GSE28863_A1 | Up | 0.6461553481 |
| GSE28863_A2 | Up | 0.3068425741 |
| GSE28863_A3 | Down | -0.3930216394 |
| GSE28863_A4 | Up | 0.1994756599 |
| GSE48662 | Down | -0.2684718767 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-141-3p | MIMAT0000432 | MIRT000317 | Luciferase reporter assay//qRT-PCR | Non-Functional MTI | 18411277 |
| hsa-miR-141-3p | MIMAT0000432 | MIRT000317 | Luciferase reporter assay | Functional MTI | 19854497 |
| hsa-miR-141-3p | MIMAT0000432 | MIRT000317 | qRT-PCR;Other | Functional MTI (Weak) | 19502803 |
| hsa-miR-429 | MIMAT0001536 | MIRT001743 | Luciferase reporter assay//qRT-PCR//Reporter assay | Non-Functional MTI | 18411277 |
| hsa-miR-429 | MIMAT0001536 | MIRT001743 | Luciferase reporter assay | Functional MTI | 19854497 |
| hsa-miR-429 | MIMAT0001536 | MIRT001743 | Luciferase reporter assay | Functional MTI | 18829540 |
| hsa-miR-429 | MIMAT0001536 | MIRT001743 | intrarenal expression | Functional MTI (Weak) | 19910931 |
| hsa-miR-200c-3p | MIMAT0000617 | MIRT002286 | Immunoblot//Luciferase reporter assay//qRT-PCR | Functional MTI | 18483486 |
| hsa-miR-200c-3p | MIMAT0000617 | MIRT002286 | Luciferase reporter assay//qRT-PCR | Non-Functional MTI | 18411277 |
| hsa-miR-200c-3p | MIMAT0000617 | MIRT002286 | qRT-PCR//Luciferase reporter assay//Western blot//Reporter assay | Functional MTI | 18381893 |
| hsa-miR-200c-3p | MIMAT0000617 | MIRT002286 | Luciferase reporter assay | Functional MTI | 19839049 |
| hsa-miR-200c-3p | MIMAT0000617 | MIRT002286 | Luciferase reporter assay | Functional MTI | 19854497 |
| hsa-miR-200c-3p | MIMAT0000617 | MIRT002286 | immunoblot//Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20049172 |
| hsa-miR-200c-3p | MIMAT0000617 | MIRT002286 | qRT-PCR//qRT-PCR;Other | Functional MTI (Weak) | 19502803 |
| hsa-miR-200c-3p | MIMAT0000617 | MIRT002286 | Immunohistochemistry//qRT-PCR | Functional MTI (Weak) | 21224848 |
| hsa-miR-200c-3p | MIMAT0000617 | MIRT002286 | Immunoblot//Luciferase reporter assay//qRT-PCR | Functional MTI | 21294122 |
| hsa-miR-200c-3p | MIMAT0000617 | MIRT002286 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 21049046 |
| hsa-miR-200c-3p | MIMAT0000617 | MIRT002286 | GFP reporter assay//qRT-PCR | Functional MTI | 16929162 |
| hsa-miR-200c-3p | MIMAT0000617 | MIRT002286 | Luciferase reporter assay//Western blot | Functional MTI | 22569286 |
| hsa-miR-200c-3p | MIMAT0000617 | MIRT002286 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 22407310 |
| hsa-miR-200c-3p | MIMAT0000617 | MIRT002286 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-205-5p | MIMAT0000266 | MIRT002478 | Luciferase reporter assay//Microarray//Western blot | Functional MTI | 18376396 |
| hsa-miR-205-5p | MIMAT0000266 | MIRT002478 | qRT-PCR;Other | Functional MTI (Weak) | 19502803 |
| hsa-miR-200a-3p | MIMAT0000682 | MIRT002480 | Luciferase reporter assay//Microarray//Western blot | Functional MTI | 18376396 |
| hsa-miR-200a-3p | MIMAT0000682 | MIRT002480 | Luciferase reporter assay//qRT-PCR//Reporter assay | Non-Functional MTI | 18411277 |
| hsa-miR-200a-3p | MIMAT0000682 | MIRT002480 | qRT-PCR//Western blot | Functional MTI | 19703993 |
| hsa-miR-200a-3p | MIMAT0000682 | MIRT002480 | qRT-PCR//Luciferase reporter assay//Western blot//Reporter assay | Functional MTI | 18381893 |
| hsa-miR-200a-3p | MIMAT0000682 | MIRT002480 | Luciferase reporter assay//qRT-PCR | Functional MTI | 19854497 |
| hsa-miR-200a-3p | MIMAT0000682 | MIRT002480 | Luciferase reporter assay | Functional MTI | 18829540 |
| hsa-miR-200a-3p | MIMAT0000682 | MIRT002480 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 21049046 |
| hsa-miR-200b-3p | MIMAT0000318 | MIRT002483 | Luciferase reporter assay//qRT-PCR//Reporter assay | Functional MTI | 18411277 |
| hsa-miR-200b-3p | MIMAT0000318 | MIRT002483 | Luciferase reporter assay | Functional MTI | 19839049 |
| hsa-miR-200b-3p | MIMAT0000318 | MIRT002483 | Luciferase reporter assay//qRT-PCR | Functional MTI | 19854497 |
| hsa-miR-200b-3p | MIMAT0000318 | MIRT002483 | Luciferase reporter assay//Microarray//Western blot | Functional MTI | 18376396 |
| hsa-miR-200b-3p | MIMAT0000318 | MIRT002483 | Luciferase reporter assay | Functional MTI | 18829540 |
| hsa-miR-200b-3p | MIMAT0000318 | MIRT002483 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 21049046 |
| hsa-miR-150-5p | MIMAT0000451 | MIRT006984 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 23013135 |
| hsa-miR-130b-3p | MIMAT0000691 | MIRT007059 | ChIP-seq//Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 22847613 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018433 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-200b-3p | MIMAT0000318 | 4 | hsa-miR-200b | 18376396 | |||
| hsa-miR-200b-3p | MIMAT0000318 | 3 | hsa-miR-200b | 18376396 | |||
| hsa-miR-200b-3p | MIMAT0000318 | 2 | hsa-miR-200b | 18376396 | |||
| hsa-miR-200b-3p | MIMAT0000318 | 5 | hsa-miR-200b | 18376396 | |||
| hsa-miR-200b-3p | MIMAT0000318 | 1 | hsa-miR-200b | 18376396 | |||
| hsa-miR-200a-3p | MIMAT0000682 | 3 | hsa-miR-200a | 18376396 | |||
| hsa-miR-200a-3p | MIMAT0000682 | 2 | hsa-miR-200a | 18376396 | |||
| hsa-miR-200a-3p | MIMAT0000682 | 1 | hsa-miR-200a | 18376396 | |||
| hsa-miR-205-5p | MIMAT0000266 | 1 | hsa-miR-205 | 18376396 | |||
| hsa-miR-200c-3p | MIMAT0000617 | 2 | hsa-miR-200c | {Western blot} | {overexpression by miRNA precursor transfection} | 18483486 | |
| hsa-miR-200c-3p | MIMAT0000617 | 1 | hsa-miR-200c | {Western blot} | {overexpression by miRNA precursor transfection} | 18483486 | |
| hsa-miR-200c-3p | MIMAT0000617 | NA | hsa-miR-200c | {phenotypic analysis of target gene} | {overexpression} | 19502803 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26813495 | The dual function of PRMT1 in modulating epithelial-mesenchymal transition and cellular senescence in breast cancer cells through regulation of ZEB1 |
| 24853424 | In addition, we show that WIF1 functions as a positive regulator of miR-200c, leading to downregulation of BMI1, ZEB1 and ZEB2, with a consequent increase in downstream targets such as E-cadherin |
| 20424117 | Epidermal growth factor receptor and mutant p53 expand an esophageal cellular subpopulation capable of epithelial-to-mesenchymal transition through ZEB transcription factors |
| 20424117 | RNA interference directed against ZEB resulted in the induction of p15(INK4B) and p16(INK4A), reactivating the EGFR-dependent senescence program |
| 20424117 | Thus, senescence checkpoint functions activated by EGFR and p53 may be evaded through the induction of ZEB, thereby allowing the expansion of an EMT-competent unique cellular subpopulation, providing novel mechanistic insights into the role of ZEB in esophageal carcinogenesis |
| 18192284 | Zeb1 links epithelial-mesenchymal transition and cellular senescence |
| 18192284 | As opposed to overexpression, we show that mutation of Zeb1 in mice causes a mesenchymal-epithelial transition in gene expression characterized by ectopic expression of epithelial genes such as E-cadherin and loss of expression of mesenchymal genes such as vimentin |
| 18192284 | In contrast to rapid proliferation in cancer cells where Zeb1 is overexpressed, this mesenchymal-epithelial transition in mutant mice is associated with diminished proliferation of progenitor cells at sites of developmental defects, including the forming palate, skeleton and CNS |
| 18192284 | Zeb1 dosage-dependent deregulation of epithelial and mesenchymal genes extends to mouse embryonic fibroblasts (MEFs), and mutant MEFs also display diminished replicative capacity in culture, leading to premature senescence |
| 18192284 | However, this Ink4a pathway is not activated during senescence of Zeb1 mutant MEFs |
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