HCSGD entry for TCF7L2

1. General information

Official gene symbolTCF7L2
Entrez ID6934
Gene full nametranscription factor 7-like 2 (T-cell specific, HMG-box)
Other gene symbolsTCF-4 TCF4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0000790Nuclear chromatinIDAcellular_component
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingIDAmolecular_function
GO:0001103RNA polymerase II repressing transcription factor bindingIPImolecular_function
GO:0001568Blood vessel developmentIMPbiological_process
GO:0003682Chromatin bindingIBAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmIDAcellular_component
GO:0005667Transcription factor complexIBAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006357Regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0007050Cell cycle arrestIMPbiological_process
GO:0007420Brain developmentIBAbiological_process
GO:0008013Beta-catenin bindingIDA IPImolecular_function
GO:0008134Transcription factor bindingIPImolecular_function
GO:0008283Cell proliferationIMPbiological_process
GO:0009749Response to glucoseISSbiological_process
GO:0010909Positive regulation of heparan sulfate proteoglycan biosynthetic processIMPbiological_process
GO:0014003Oligodendrocyte developmentIEAbiological_process
GO:0016055Wnt signaling pathwayIEAbiological_process
GO:0016605PML bodyIEAcellular_component
GO:0019901Protein kinase bindingIPImolecular_function
GO:0021915Neural tube developmentIEAbiological_process
GO:0021983Pituitary gland developmentIEAbiological_process
GO:0030282Bone mineralizationIEAbiological_process
GO:0030514Negative regulation of BMP signaling pathwayIEAbiological_process
GO:0030538Embryonic genitalia morphogenesisIEAbiological_process
GO:0031016Pancreas developmentTASbiological_process
GO:0031641Regulation of myelinationIEAbiological_process
GO:0032024Positive regulation of insulin secretionIDA IMPbiological_process
GO:0032092Positive regulation of protein bindingIDAbiological_process
GO:0032252Secretory granule localizationIEAbiological_process
GO:0032350Regulation of hormone metabolic processIDAbiological_process
GO:0032993Protein-DNA complexIDAcellular_component
GO:0035019Somatic stem cell maintenanceIEAbiological_process
GO:0035257Nuclear hormone receptor bindingIPImolecular_function
GO:0035411Catenin import into nucleusIEAbiological_process
GO:0040037Negative regulation of fibroblast growth factor receptor signaling pathwayIEAbiological_process
GO:0042475Odontogenesis of dentin-containing toothIEAbiological_process
GO:0042593Glucose homeostasisIDAbiological_process
GO:0043065Positive regulation of apoptotic processIEAbiological_process
GO:0043433Negative regulation of sequence-specific DNA binding transcription factor activityIDAbiological_process
GO:0043565Sequence-specific DNA bindingIDA IMPmolecular_function
GO:0043570Maintenance of DNA repeat elementsIMPbiological_process
GO:0043588Skin developmentIEAbiological_process
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0044334Canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transitionIMPbiological_process
GO:0045295Gamma-catenin bindingIPImolecular_function
GO:0045444Fat cell differentiationIDAbiological_process
GO:0045599Negative regulation of fat cell differentiationIEAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDA IMPbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046621Negative regulation of organ growthIEAbiological_process
GO:0046827Positive regulation of protein export from nucleusIMPbiological_process
GO:0048557Embryonic digestive tract morphogenesisIEAbiological_process
GO:0048619Embryonic hindgut morphogenesisIEAbiological_process
GO:0048625Myoblast fate commitmentIDAbiological_process
GO:0048641Regulation of skeletal muscle tissue developmentIEAbiological_process
GO:0048660Regulation of smooth muscle cell proliferationIMPbiological_process
GO:0048699Generation of neuronsIBAbiological_process
GO:0048713Regulation of oligodendrocyte differentiationIEAbiological_process
GO:0050679Positive regulation of epithelial cell proliferationIEAbiological_process
GO:0051897Positive regulation of protein kinase B signalingIMPbiological_process
GO:0060070Canonical Wnt signaling pathwayICbiological_process
GO:0060325Face morphogenesisIEAbiological_process
GO:0061178Regulation of insulin secretion involved in cellular response to glucose stimulusIEAbiological_process
GO:0070016Armadillo repeat domain bindingIPImolecular_function
GO:0070369Beta-catenin-TCF7L2 complexIDAcellular_component
GO:0090090Negative regulation of canonical Wnt signaling pathwayIMPbiological_process
GO:2000675Negative regulation of type B pancreatic cell apoptotic processIDAbiological_process
GO:2001237Negative regulation of extrinsic apoptotic signaling pathwayIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.25910492380.40100849130.95247792211.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3257538813
GSE13712_SHEARUp0.1365961086
GSE13712_STATICDown-0.0713166244
GSE19018Up0.0510282623
GSE19899_A1Down-0.1299890033
GSE19899_A2Up0.2643391833
PubMed_21979375_A1Up0.0966461053
PubMed_21979375_A2Up0.3295024178
GSE35957Down-0.0799947678
GSE36640Down-0.6936151747
GSE54402Up0.4212020279
GSE9593Down-0.4364362377
GSE43922Up0.0502075642
GSE24585Down-0.1052834775
GSE37065Up0.2133664840
GSE28863_A1Up0.4182654852
GSE28863_A2Down-0.5470938868
GSE28863_A3Up0.2037074064
GSE28863_A4Up0.1233929946
GSE48662Up0.3195749367

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-324-5pMIMAT0000761MIRT043052CLASHFunctional MTI (Weak)23622248
hsa-miR-148b-3pMIMAT0000759MIRT043583CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.