HCSGD entry for HNF1B

1. General information

Official gene symbolHNF1B
Entrez ID6928
Gene full nameHNF1 homeobox B
Other gene symbolsFJHN HNF-1B HNF1beta HNF2 HPC11 LF-B3 LFB3 MODY5 TCF-2 TCF2 VHNF1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0001714Endodermal cell fate specificationIEAbiological_process
GO:0001822Kidney developmentIDA IMPbiological_process
GO:0001826Inner cell mass cell differentiationIEAbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDA IEAmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005667Transcription factor complexIEAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0009749Response to glucoseIEAbiological_process
GO:0009952Anterior/posterior pattern specificationIEAbiological_process
GO:0030073Insulin secretionIEAbiological_process
GO:0030111Regulation of Wnt signaling pathwayIEAbiological_process
GO:0030902Hindbrain developmentIEAbiological_process
GO:0031018Endocrine pancreas developmentIMP TASbiological_process
GO:0035565Regulation of pronephros sizeIMPbiological_process
GO:0039020Pronephric nephron tubule developmentIGIbiological_process
GO:0042663Regulation of endodermal cell fate specificationIEAbiological_process
GO:0042803Protein homodimerization activityIEA IPImolecular_function
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0044212Transcription regulatory region DNA bindingIEAmolecular_function
GO:0045893Positive regulation of transcription, DNA-templatedIDA IEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0046982Protein heterodimerization activityIEAmolecular_function
GO:0048557Embryonic digestive tract morphogenesisIEAbiological_process
GO:0048754Branching morphogenesis of an epithelial tubeIEAbiological_process
GO:0048793Pronephros developmentIMPbiological_process
GO:0048806Genitalia developmentIMPbiological_process
GO:0050673Epithelial cell proliferationIEAbiological_process
GO:0060261Positive regulation of transcription initiation from RNA polymerase II promoterIDAbiological_process
GO:0060677Ureteric bud elongationIEAbiological_process
GO:0061017Hepatoblast differentiationIEAbiological_process
GO:0061296Negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesisIEAbiological_process
GO:0072095Regulation of branch elongation involved in ureteric bud branchingIEAbiological_process
GO:0072181Mesonephric duct formationIEAbiological_process
GO:1900212Negative regulation of mesenchymal cell apoptotic process involved in metanephros developmentIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.74394609250.52346294210.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0317680369
GSE13712_SHEARUp0.0167322101
GSE13712_STATICDown-0.0854694485
GSE19018Up0.0916392212
GSE19899_A1Up0.0431609531
GSE19899_A2Up0.1285081178
PubMed_21979375_A1Down-0.1076573315
PubMed_21979375_A2Up0.2530566616
GSE35957Up0.1718643481
GSE36640Up0.0747446046
GSE54402Up0.0847394962
GSE9593Up0.1557218399
GSE43922Up0.0115638150
GSE24585Down-0.2032237393
GSE37065Down-0.0328020975
GSE28863_A1Down-0.4478666442
GSE28863_A2Down-0.3501633982
GSE28863_A3Up0.2383536314
GSE28863_A4Up0.0658397557
GSE48662Up0.0002538830

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-215-5pMIMAT0000272MIRT024651MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026957MicroarrayFunctional MTI (Weak)19074876
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.