HCSGD entry for HNF1A

1. General information

Official gene symbolHNF1A
Entrez ID6927
Gene full nameHNF1 homeobox A
Other gene symbolsHNF-1A HNF1 IDDM20 LFB1 MODY3 TCF-1 TCF1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionISSmolecular_function
GO:0001750Photoreceptor outer segmentIEAcellular_component
GO:0001824Blastocyst developmentIEAbiological_process
GO:0001889Liver developmentIEAbiological_process
GO:0001890Placenta developmentIEAbiological_process
GO:0003677DNA bindingIDA IEAmolecular_function
GO:0003690Double-stranded DNA bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005667Transcription factor complexIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0006338Chromatin remodelingIEAbiological_process
GO:0006357Regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0006633Fatty acid biosynthetic processIEAbiological_process
GO:0006699Bile acid biosynthetic processIEAbiological_process
GO:0006783Heme biosynthetic processIEAbiological_process
GO:0006979Response to oxidative stressIEAbiological_process
GO:0008104Protein localizationIEAbiological_process
GO:0008134Transcription factor bindingIEAmolecular_function
GO:0008203Cholesterol metabolic processIEAbiological_process
GO:0009749Response to glucoseIEAbiological_process
GO:0015721Bile acid and bile salt transportIEAbiological_process
GO:0015908Fatty acid transportIEAbiological_process
GO:0030073Insulin secretionIEA IMPbiological_process
GO:0030111Regulation of Wnt signaling pathwayIEAbiological_process
GO:0030326Embryonic limb morphogenesisIEAbiological_process
GO:0031018Endocrine pancreas developmentIEAbiological_process
GO:0035565Regulation of pronephros sizeIMPbiological_process
GO:0035623Renal glucose absorptionIMPbiological_process
GO:0042593Glucose homeostasisIMPbiological_process
GO:0042803Protein homodimerization activityIEA IPImolecular_function
GO:0043234Protein complexIDAcellular_component
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0043691Reverse cholesterol transportIEAbiological_process
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045120PronucleusIEAcellular_component
GO:0045453Bone resorptionIEAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDA IEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0046323Glucose importIMPbiological_process
GO:0046982Protein heterodimerization activityIDA IEAmolecular_function
GO:0046983Protein dimerization activityIPImolecular_function
GO:0048341Paraxial mesoderm formationIEAbiological_process
GO:0048608Reproductive structure developmentIEAbiological_process
GO:0050796Regulation of insulin secretionIEAbiological_process
GO:0060261Positive regulation of transcription initiation from RNA polymerase II promoterIGIbiological_process
GO:0060395SMAD protein signal transductionIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.40632673910.88748736370.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0933746756
GSE13712_SHEARDown-0.0137105764
GSE13712_STATICDown-0.1790458277
GSE19018Up0.0594312451
GSE19899_A1Down-0.0284206661
GSE19899_A2Up0.2159230313
PubMed_21979375_A1Down-0.0543249854
PubMed_21979375_A2Down-0.1418945464
GSE35957Up0.1716388339
GSE36640Up0.0943535138
GSE54402Up0.0218251792
GSE9593Up0.0529635589
GSE43922Up0.1607968860
GSE24585Up0.0279094818
GSE37065Up0.0451795616
GSE28863_A1Down-0.0505411773
GSE28863_A2Down-0.0321967421
GSE28863_A3Up0.4453552655
GSE28863_A4Up0.2274520785
GSE48662Up0.0770152125

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

NorleucineDB04419 EXPT02355

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-320aMIMAT0000510MIRT044838CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

14522900Suppression of AFP gene transcription by ING was strongly dependent on AT-motifs that bind to the hepatocyte nuclear factor 1 (HNF1) transcription factor
14522900Indeed, electrophoretic mobility shift assays confirmed that HNF1 binds to AT-motifs, but we found, surprisingly, that the ING1 complexes binding to these AT-motifs were devoid of HNF1 protein
14522900The first is by binding to the AT-motif and excluding HNF1 binding while possibly targeting HAT activity to promoter regions, and the second is by increasing the levels of active, acetylated p53 via binding and inhibiting the ability of hSIR2 to deacetylate p53 protein
11237869This technique resulted in the cloning of a novel counterpart of the previously cloned chicken dimerization cofactor of hepatocyte nuclear factor (HNF)-1 (cDcoH), which was identified as cDcoHalpha
11237869When transfected into human HepG2 cells, both cDcoH and cDcoHalpha showed similar functional activity as measured by increased expression of a reporter gene, as well as alpha-fetoprotein and albumin genes that both contain HNF-1 binding elements in their promoters
11237869Our results suggest that the novel chicken DcoHalpha might function as a transcriptional cofactor for HNF-1 in specific cellular-environmental states
10092208Analysis of the expression of relevant hepatic genes by reverse Northern and semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR) revealed that culturing hepatocytes in collagen gels results in a sustained higher expression of key liver transcription factor genes DBP, C/EBP-alpha and -beta, and HNF-1 and -4, as well as specific liver enzyme genes (phosphoenol pyryvate carboxykinase, and carbamoylphosphate-synthetase I)
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