HCSGD entry for TBX3

1. General information

Official gene symbolTBX3
Entrez ID6926
Gene full nameT-box 3
Other gene symbolsTBX3-ISO UMS XHL
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0001085RNA polymerase II transcription factor bindingISSmolecular_function
GO:0001102RNA polymerase II activating transcription factor bindingISSmolecular_function
GO:0001501Skeletal system developmentIMPbiological_process
GO:0001568Blood vessel developmentIEAbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001947Heart loopingIEAbiological_process
GO:0003151Outflow tract morphogenesisIEAbiological_process
GO:0003167Atrioventricular bundle cell differentiationIEAbiological_process
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006357Regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0007569Cell agingIDAbiological_process
GO:0008284Positive regulation of cell proliferationIDAbiological_process
GO:0008595Anterior/posterior axis specification, embryoIMPbiological_process
GO:0009887Organ morphogenesisIDAbiological_process
GO:0010159Specification of organ positionIEAbiological_process
GO:0019827Stem cell maintenanceIEAbiological_process
GO:0021761Limbic system developmentIEAbiological_process
GO:0030539Male genitalia developmentIMPbiological_process
GO:0030540Female genitalia developmentIMPbiological_process
GO:0030857Negative regulation of epithelial cell differentiationIEAbiological_process
GO:0030879Mammary gland developmentIMPbiological_process
GO:0032275Luteinizing hormone secretionIMPbiological_process
GO:0035115Embryonic forelimb morphogenesisIMPbiological_process
GO:0035136Forelimb morphogenesisIDAbiological_process
GO:0042733Embryonic digit morphogenesisIMPbiological_process
GO:0043066Negative regulation of apoptotic processIDAbiological_process
GO:0043565Sequence-specific DNA bindingIDAmolecular_function
GO:0045662Negative regulation of myoblast differentiationIDAbiological_process
GO:0045787Positive regulation of cell cycleIDAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIEAbiological_process
GO:0046884Follicle-stimulating hormone secretionIMPbiological_process
GO:0048332Mesoderm morphogenesisIMPbiological_process
GO:0060021Palate developmentIEAbiological_process
GO:0060412Ventricular septum morphogenesisIEAbiological_process
GO:0060444Branching involved in mammary gland duct morphogenesisIEAbiological_process
GO:0060596Mammary placode formationIEAbiological_process
GO:0060923Cardiac muscle cell fate commitmentIEAbiological_process
GO:0060931Sinoatrial node cell developmentIEAbiological_process
GO:0090398Cellular senescenceIDAbiological_process
GO:2000648Positive regulation of stem cell proliferationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.05166232670.88690034190.49813183321.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2699128974
GSE13712_SHEARUp0.0121657262
GSE13712_STATICDown-0.0525662789
GSE19018Down-0.1992066404
GSE19899_A1Up0.2250762755
GSE19899_A2Up0.0359932508
PubMed_21979375_A1Up0.4592694858
PubMed_21979375_A2Up0.2428794826
GSE35957Down-0.0653125482
GSE36640Down-0.6051107739
GSE54402Up0.4928168135
GSE9593Up0.0124306542
GSE43922Up0.1826406366
GSE24585Down-0.3673842413
GSE37065Up0.2662228197
GSE28863_A1Up0.5316330081
GSE28863_A2Up0.5708144998
GSE28863_A3Up0.6262432959
GSE28863_A4Up0.0288793203
GSE48662Down-0.2323787954

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-128-3pMIMAT0000424MIRT022052MicroarrayFunctional MTI (Weak)17612493
hsa-miR-22-3pMIMAT0000077MIRT030639SequencingFunctional MTI (Weak)20371350
hsa-miR-1226-3pMIMAT0005577MIRT036446CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24876127Coordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex
24876127Critical, previously unknown roles for CAPERalpha in controlling cell proliferation are manifest in an obligatory interaction with TBX3 to regulate chromatin structure and repress transcription of CDKN2A-p16INK and the RB pathway
24876127Our elucidation of CAPERalpha and UCA1 functions in vivo provides new insights into senescence induction, and the oncogenic and developmental properties of TBX3
15781639Overexpression of Tbx2 and the related factor Tbx3, which is also overexpressed in breast cancer and melanomas, can suppress senescence in defined experimental systems through repression of ARF expression
15781639However, it is not known how Tbx2 mediates its repressive effect nor whether endogenous Tbx2 or Tbx3 perform a similar antisenescence function in transformed cells
15136151We found significant repression of Tbx2 and Tbx3, both linked to inhibition of cellular senescence, in Shh(-/-) and partial derepression in Shh(-/-); Gli3(-/-) lungs, while Tbx4 and Tbx5 expressions are less affected in the mutants
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