HCSGD entry for TCF4
1. General information
| Official gene symbol | TCF4 |
|---|---|
| Entrez ID | 6925 |
| Gene full name | transcription factor 4 |
| Other gene symbols | E2-2 ITF-2 ITF2 PTHS SEF-2 SEF2 SEF2-1 SEF2-1A SEF2-1B TCF-4 bHLHb19 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | IEA ISS | molecular_function |
| GO:0001011 | Sequence-specific DNA binding RNA polymerase recruiting transcription factor activity | IEA ISS | molecular_function |
| GO:0001077 | RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription | IEA ISS | molecular_function |
| GO:0001087 | TFIIB-class binding transcription factor activity | IEA ISS | molecular_function |
| GO:0001093 | TFIIB-class transcription factor binding | IEA ISS | molecular_function |
| GO:0003677 | DNA binding | IDA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IDA | molecular_function |
| GO:0003714 | Transcription corepressor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005667 | Transcription factor complex | IEA ISS | cellular_component |
| GO:0006352 | DNA-templated transcription, initiation | ISS | biological_process |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | IEA ISS | biological_process |
| GO:0008022 | Protein C-terminus binding | IPI | molecular_function |
| GO:0045666 | Positive regulation of neuron differentiation | IEA ISS | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | ISS | biological_process |
| GO:0046982 | Protein heterodimerization activity | IEA ISS NAS | molecular_function |
| GO:0046983 | Protein dimerization activity | IEA | molecular_function |
| GO:0065004 | Protein-DNA complex assembly | IEA ISS | biological_process |
| GO:0070888 | E-box binding | IEA ISS | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9796650735 | 0.0020954409 | 0.9999902473 | 0.0876853736 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.8142576009 |
| GSE13712_SHEAR | Up | 0.0507809784 |
| GSE13712_STATIC | Down | -0.6170056911 |
| GSE19018 | Down | -0.8353716986 |
| GSE19899_A1 | Down | -0.6916872135 |
| GSE19899_A2 | Down | -1.6281434352 |
| PubMed_21979375_A1 | Down | -0.6092306378 |
| PubMed_21979375_A2 | Down | -1.0409561374 |
| GSE35957 | Down | -0.2909281784 |
| GSE36640 | Down | -0.9296025424 |
| GSE54402 | Up | 0.3014200537 |
| GSE9593 | Down | -0.5143039108 |
| GSE43922 | Down | -0.2293651355 |
| GSE24585 | Down | -0.7767049841 |
| GSE37065 | Up | 0.1479822917 |
| GSE28863_A1 | Up | 0.5559135403 |
| GSE28863_A2 | Up | 0.0884316081 |
| GSE28863_A3 | Down | -0.5616502853 |
| GSE28863_A4 | Down | -0.0748780286 |
| GSE48662 | Down | -0.0265688013 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-204-5p | MIMAT0000265 | MIRT005846 | Luciferase reporter assay//Microarray//qRT-PCR | Functional MTI | 21282569 |
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020336 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT031229 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051694 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27129219 | HBP1-mediated Regulation of p21 Protein through the Mdm2/p53 and TCF4/EZH2 Pathways and Its Impact on Cell Senescence and Tumorigenesis |
| 27129219 | HBP1-mediated elevation of p21 through the Mdm2/p53 and TCF4/EZH2 pathways contributes to both cellular senescence and tumor inhibition |
| 25567807 | Here, we investigated the role of endoplasmic reticulum (ER) stress-regulated activation of transcription factor 4 (ATF4)/p16 signaling in the premature senescence of renal tubular epithelial cells (RTECs) during DN development |
| 24853424 | Consistent with this observation, WIF1 caused a reduction in the expression of pluripotency and stemness markers (OCT4 and c-MYC), as well as adult stem cell self-renewal and multi-lineage differentiation markers, such as WNT3A, TCF4, c-KIT and MYB |
| 23763475 | H2 O2 upregulated the expression of osteoblast- and adipocyte-associated genes in iPSC during their differentiation; however, short-term H2 O2 -induced oxidative stress did not affect the protein expression of the pluripotency markers, octamer-binding transcription factor 4 and sex-determining region Y-box 2 |
| 23229510 | An important effector of the ISR is activating transcription factor 4 (ATF4), a transcription factor that regulates genes involved in redox homeostasis and amino acid metabolism and transport |
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