HCSGD entry for TBX5

1. General information

Official gene symbolTBX5
Entrez ID6910
Gene full nameT-box 5
Other gene symbolsHOS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000977RNA polymerase II regulatory region sequence-specific DNA bindingIEAmolecular_function
GO:0001228RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIEAmolecular_function
GO:0002009Morphogenesis of an epitheliumIEAbiological_process
GO:0003166Bundle of His developmentIEAbiological_process
GO:0003181Atrioventricular valve morphogenesisIEAbiological_process
GO:0003197Endocardial cushion developmentIEAbiological_process
GO:0003218Cardiac left ventricle formationISSbiological_process
GO:0003229Ventricular cardiac muscle tissue developmentIEAbiological_process
GO:0003281Ventricular septum developmentISSbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDA IMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005667Transcription factor complexIEAcellular_component
GO:0005737CytoplasmIDA TAScellular_component
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0007267Cell-cell signalingIDAbiological_process
GO:0007389Pattern specification processIEAbiological_process
GO:0007507Heart developmentIDA IMPbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0008285Negative regulation of cell proliferationIDAbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0010719Negative regulation of epithelial to mesenchymal transitionTASbiological_process
GO:0030262Apoptotic nuclear changesIDAbiological_process
GO:0030324Lung developmentIEAbiological_process
GO:0030326Embryonic limb morphogenesisIMPbiological_process
GO:0030336Negative regulation of cell migrationIDAbiological_process
GO:0035115Embryonic forelimb morphogenesisIMPbiological_process
GO:0035136Forelimb morphogenesisIMPbiological_process
GO:0043565Sequence-specific DNA bindingIDAmolecular_function
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIMPbiological_process
GO:0051891Positive regulation of cardioblast differentiationIDAbiological_process
GO:0055007Cardiac muscle cell differentiationIEAbiological_process
GO:0060039Pericardium developmentIDAbiological_process
GO:0060044Negative regulation of cardiac muscle cell proliferationIDAbiological_process
GO:0060045Positive regulation of cardiac muscle cell proliferationIEAbiological_process
GO:0060413Atrial septum morphogenesisIEAbiological_process
GO:0060980Cell migration involved in coronary vasculogenesisTASbiological_process
GO:0072513Positive regulation of secondary heart field cardioblast proliferationIEAbiological_process
GO:1900117Regulation of execution phase of apoptosisICbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.91820187300.03544266560.99999024730.3568256498

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0786844166
GSE13712_SHEARUp0.0447325367
GSE13712_STATICUp0.0675837009
GSE19018Up0.0635591970
GSE19899_A1Down-0.3167051713
GSE19899_A2Down-1.0394546636
PubMed_21979375_A1Down-2.1306120090
PubMed_21979375_A2Down-0.8994716736
GSE35957Up0.1347672486
GSE36640Up0.2990337014
GSE54402Down-0.3569451515
GSE9593Up0.0187880113
GSE43922Down-1.2093531743
GSE24585Down-0.1931058966
GSE37065Down-0.0432057910
GSE28863_A1Up0.2597203955
GSE28863_A2Down-0.2218985860
GSE28863_A3Up0.2366401728
GSE28863_A4Up0.1383323143
GSE48662Up0.0163562282

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018791MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

15136151We found significant repression of Tbx2 and Tbx3, both linked to inhibition of cellular senescence, in Shh(-/-) and partial derepression in Shh(-/-); Gli3(-/-) lungs, while Tbx4 and Tbx5 expressions are less affected in the mutants
8485202For initial human cell transformation studies, a flat, nontumorigenic clonal line, originally derived from a human osteosarcoma (HOS), was used
8485202These cell lines were very useful inasmuch as a non-ras cellular transforming gene, met, and an activated H-ras oncogene have been isolated from MNNG-transformed and 3MC-transformed HOS lines, respectively, by DNA transfection procedure
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