HCSGD entry for TBX2

1. General information

Official gene symbolTBX2
Entrez ID6909
Gene full nameT-box 2
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0003148Outflow tract septum morphogenesisISSbiological_process
GO:0003151Outflow tract morphogenesisISSbiological_process
GO:0003203Endocardial cushion morphogenesisISSbiological_process
GO:0003256Regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiationISSbiological_process
GO:0003677DNA bindingTASmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005667Transcription factor complexIEAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0007521Muscle cell fate determinationISSbiological_process
GO:0007569Cell agingIDAbiological_process
GO:0008284Positive regulation of cell proliferationIDAbiological_process
GO:0035909Aorta morphogenesisISSbiological_process
GO:0036302Atrioventricular canal developmentISSbiological_process
GO:0042733Embryonic digit morphogenesisISSbiological_process
GO:0043565Sequence-specific DNA bindingIDAmolecular_function
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0048596Embryonic camera-type eye morphogenesisISSbiological_process
GO:0048738Cardiac muscle tissue developmentISSbiological_process
GO:0060021Palate developmentIEAbiological_process
GO:0060045Positive regulation of cardiac muscle cell proliferationISSbiological_process
GO:0060465Pharynx developmentISSbiological_process
GO:0060560Developmental growth involved in morphogenesisIEAbiological_process
GO:0060596Mammary placode formationIEAbiological_process
GO:0090398Cellular senescenceIDAbiological_process
GO:1901208Negative regulation of heart loopingISSbiological_process
GO:1901211Negative regulation of cardiac chamber formationISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.75886405530.32963704270.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1976305641
GSE13712_SHEARDown-0.0030068808
GSE13712_STATICDown-0.1367682441
GSE19018Down-0.4241344696
GSE19899_A1Down-0.3746187580
GSE19899_A2Down-0.2584641406
PubMed_21979375_A1Down-0.3431072020
PubMed_21979375_A2Up0.1339497112
GSE35957Down-0.3194537988
GSE36640Up0.3601387908
GSE54402Up0.1922362724
GSE9593Up0.0222209433
GSE43922Down-0.0151351058
GSE24585Up0.0006310512
GSE37065Up0.0565921728
GSE28863_A1Down-0.0674006298
GSE28863_A2Down-0.0938677937
GSE28863_A3Up0.2569258889
GSE28863_A4Up0.1544534194
GSE48662Down-0.1491822151

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022554MicroarrayFunctional MTI (Weak)18668037
hsa-miR-744-5pMIMAT0004945MIRT037721CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22002537Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence
22002537Combining gene expression profiling with chromatin-binding analyses and promoter reporter studies, we identify TBX2, a T-box transcription factor frequently overexpressed in cancer, as a novel and direct PML-repressible E2F-target gene in senescence but not quiescence
22002537Recruitment of PML to the TBX2 promoter is dependent on a functional p130/E2F4 repressor complex ultimately implementing a transcriptionally inactive chromatin environment at the TBX2 promoter
22002537TBX2 repression actively contributes to senescence induction as cells depleted for TBX2 trigger PML pro-senescence function(s) and enter senescence
22002537Reciprocally, elevated TBX2 levels antagonize PML pro-senescence function through direct protein-protein interaction
22002537Collectively, our findings indicate that PML and TBX2 act in an autoregulatory loop to control the effective execution of the senescence program
20348948T-box 2 represses NDRG1 through an EGR1-dependent mechanism to drive the proliferation of breast cancer cells
20348948T-box 2 (TBX2) is a transcription factor involved in mammary development and is known to be overexpressed in a subset of aggressive breast cancers
20348948TBX2 has previously been shown to repress growth control genes such as p14(ARF) and p21(WAF1/cip1)
20348948In this study we show that TBX2 drives proliferation in breast cancer cells and this is abrogated after TBX2 small interfering RNA (siRNA) knockdown or after the expression of a dominant-negative TBX2 protein
20348948We show EGR1 is required for the ability of TBX2 to repress NDRG1 and drive cell proliferation
20348948We show that TBX2 interacts with EGR1 and that TBX2 requires EGR1 to target the NDRG1 proximal promoter
20348948Abrogation of either TBX2 or EGR1 expression is accompanied by the upregulation of cell senescence and apoptotic markers
18353141Loci with established importance in melanoma, like CDKN2A, BRAF and PTEN, have been joined by some less familiar genes including transcription factor sequences TBX2 and STK11 (LKB)
15781639Tbx2 is overexpressed and plays an important role in maintaining proliferation and suppression of senescence in melanomas
15781639The TBX2 gene encoding a key developmental transcription factor is amplified in pancreatic cancer cell lines and preferentially amplified and overexpressed in BRCA1 and BRCA2 mutated breast tumors
15781639Overexpression of Tbx2 and the related factor Tbx3, which is also overexpressed in breast cancer and melanomas, can suppress senescence in defined experimental systems through repression of ARF expression
15781639However, it is not known how Tbx2 mediates its repressive effect nor whether endogenous Tbx2 or Tbx3 perform a similar antisenescence function in transformed cells
15781639This is a particularly important question because the loss of CDKN2A in many human cancers would, in principle, bypass the requirement for Tbx2/3-mediated repression of ARF in suppressing senescence
15781639We show here that Tbx2 is overexpressed in melanoma cell lines and that Tbx2 targets histone deacetylase 1 to the p21Cip1 (CDKN1A) initiator
15781639Strikingly, expression of an inducible dominant-negative Tbx2 (dnTbx2) leads to displacement of histone deacetylase 1, up-regulation of p21(Cip1) expression, and the induction of replicative senescence in CDKN2A-null B16 melanoma cells
15781639The results suggest that the activity of endogenous Tbx2 is critically required to maintain proliferation and suppress senescence in melanomas
15136151We found significant repression of Tbx2 and Tbx3, both linked to inhibition of cellular senescence, in Shh(-/-) and partial derepression in Shh(-/-); Gli3(-/-) lungs, while Tbx4 and Tbx5 expressions are less affected in the mutants
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