HCSGD entry for TBX1

1. General information

Official gene symbolTBX1
Entrez ID6899
Gene full nameT-box 1
Other gene symbolsCAFS CTHM DGCR DGS DORV TBX1C TGA VCFS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001525AngiogenesisISSbiological_process
GO:0001568Blood vessel developmentISSbiological_process
GO:0001708Cell fate specificationISSbiological_process
GO:0001755Neural crest cell migrationISSbiological_process
GO:0001934Positive regulation of protein phosphorylationISSbiological_process
GO:0001945Lymph vessel developmentISSbiological_process
GO:0001974Blood vessel remodelingIEAbiological_process
GO:0002053Positive regulation of mesenchymal cell proliferationISSbiological_process
GO:0003007Heart morphogenesisISSbiological_process
GO:0003148Outflow tract septum morphogenesisISSbiological_process
GO:0003151Outflow tract morphogenesisISSbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006357Regulation of transcription from RNA polymerase II promoterISS NASbiological_process
GO:0007368Determination of left/right symmetryISSbiological_process
GO:0007389Pattern specification processISSbiological_process
GO:0007498Mesoderm developmentISSbiological_process
GO:0007507Heart developmentIMPbiological_process
GO:0007517Muscle organ developmentISSbiological_process
GO:0007605Sensory perception of soundISSbiological_process
GO:0008283Cell proliferationISSbiological_process
GO:0008284Positive regulation of cell proliferationISSbiological_process
GO:0009952Anterior/posterior pattern specificationISSbiological_process
GO:0021644Vagus nerve morphogenesisISSbiological_process
GO:0030855Epithelial cell differentiationISSbiological_process
GO:0030878Thyroid gland developmentISSbiological_process
GO:0035176Social behaviorISSbiological_process
GO:0035909Aorta morphogenesisISSbiological_process
GO:0042471Ear morphogenesisISSbiological_process
GO:0042472Inner ear morphogenesisISSbiological_process
GO:0042473Outer ear morphogenesisISSbiological_process
GO:0042474Middle ear morphogenesisISSbiological_process
GO:0042475Odontogenesis of dentin-containing toothISSbiological_process
GO:0042693Muscle cell fate commitmentISSbiological_process
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0043410Positive regulation of MAPK cascadeISSbiological_process
GO:0043565Sequence-specific DNA bindingIDAmolecular_function
GO:0043587Tongue morphogenesisISSbiological_process
GO:0044344Cellular response to fibroblast growth factor stimulusISSbiological_process
GO:0045596Negative regulation of cell differentiationISSbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDA ISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0046983Protein dimerization activityTASmolecular_function
GO:0048384Retinoic acid receptor signaling pathwayISSbiological_process
GO:0048514Blood vessel morphogenesisISSbiological_process
GO:0048538Thymus developmentIMPbiological_process
GO:0048644Muscle organ morphogenesisISSbiological_process
GO:0048701Embryonic cranial skeleton morphogenesisISSbiological_process
GO:0048703Embryonic viscerocranium morphogenesisIMPbiological_process
GO:0048752Semicircular canal morphogenesisISSbiological_process
GO:0048844Artery morphogenesisISSbiological_process
GO:0050679Positive regulation of epithelial cell proliferationISSbiological_process
GO:0060017Parathyroid gland developmentIMPbiological_process
GO:0060023Soft palate developmentIMPbiological_process
GO:0060037Pharyngeal system developmentIMPbiological_process
GO:0060325Face morphogenesisISSbiological_process
GO:0060415Muscle tissue morphogenesisISSbiological_process
GO:0060982Coronary artery morphogenesisISSbiological_process
GO:0070166Enamel mineralizationISSbiological_process
GO:0071300Cellular response to retinoic acidISSbiological_process
GO:0071600Otic vesicle morphogenesisIEAbiological_process
GO:0072513Positive regulation of secondary heart field cardioblast proliferationIEAbiological_process
GO:0090103Cochlea morphogenesisISSbiological_process
GO:0097152Mesenchymal cell apoptotic processISSbiological_process
GO:2000027Regulation of organ morphogenesisISSbiological_process
GO:2001037Positive regulation of tongue muscle cell differentiationISSbiological_process
GO:2001054Negative regulation of mesenchymal cell apoptotic processISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.08127220850.95238451430.60122703771.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0500930259
GSE13712_SHEARUp1.4370289323
GSE13712_STATICUp1.1517976159
GSE19018Up0.0982896489
GSE19899_A1Up0.1510093931
GSE19899_A2Up0.2018931024
PubMed_21979375_A1Up0.1405586806
PubMed_21979375_A2Up0.0241562754
GSE35957Down-0.0971048184
GSE36640Up0.0919605481
GSE54402Up0.0857202622
GSE9593Up0.0441582498
GSE43922Up0.0706939381
GSE24585Down-0.2727206916
GSE37065Up0.0402128101
GSE28863_A1Down-0.0288713324
GSE28863_A2Down-0.0041354421
GSE28863_A3Up0.4459500350
GSE28863_A4Up0.0535920102
GSE48662Up0.1868581822

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1180-3pMIMAT0005825MIRT035924CLASHFunctional MTI (Weak)23622248
hsa-miR-744-5pMIMAT0004945MIRT037556CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT041674CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 8 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27081703The Cancer Genome Atlas network has revealed that the 'mesenchymal' epithelial ovarian cancer (EOC) subtype represents the poorest outcome, indicating a crucial role of stromal cancer-associated fibroblasts (CAFs) in disease progression
27081703The cooperative role of CAFs in EOC metastasis has long been recognized, but the mechanisms of stromal CAFs activation are still obscure
27081703Therefore, we carried out an integrative analysis to identify the regulator genes that are responsible for CAFs activation in microdissected tumor stroma profiles
27081703Here, we determined that myristoylated alanine-rich C-kinase substrate (MARCKS) was highly expressed in ovarian stroma, and was required for the differentiation and tumor promoting function of CAFs
27081703Suppression of MARCKS resulted in the loss of CAF features, and diminished role of CAFs in supporting tumor cell growth in 3D organotypic cultures and in murine xenograft model
27074587RNA-Seq and gene set enrichment anylysis revealed that ovarian cancer associated fibroblasts (CAFs) are mitotically active compared with normal fibroblasts (NFs)
27074587Cellular senescence is observed in CAFs treated with H2O2 as shown by elevated SA-beta-gal activity and p21 (WAF1/Cip1) protein levels
27074587Blockage of autophagy can increase ROS production in CAFs, leading to cell cycle arrest in S phase, cell proliferation inhibition and enhanced sensitivity to H2O2-induced cell death
27074587There was relatively high lactate content in CAFs than in NFs
27074587Blockage of autophagy can sensitize CAFs to chemotherapeutic drug cisplatin, implicating that autophagy might possess clinical utility as an attractive target for ovarian cancer treatment in the future
26629698OSCCs, especially those that have bypassed cellular senescence, produce an array of proteins and metabolites that induce cellular senescence in the normal surrounding cells; indeed, senescence is a common property of cancer-associated fibroblasts (CAFs)
26629698Thus, not all keratinocytes in the tumour tissue may be tumourigenic and may instead act as promoters of tumour growth and progression analogous to the much-studied CAFs which co-evolve with the genetically altered tumourigenic cells
24074947However, recent evidence suggests that the initiation and development of epithelial cancer results from a close interplay with its altered tissue microenvironment, with chronic inflammation, stromal senescence, autophagy, and the activation of cancer-associated fibroblasts (CAFs) playing possible primary roles
24579734Throughout the review we attempt to draw many parallels to other systems including the role senescent cells play in the tumor microenvironment and their significant molecular and phenotypic similarities to cancer associated fibroblasts (CAFs)
22500976BACKGROUND: Cancer-Associated Fibroblasts (CAFs) are significant components of solid malignancies and play central roles in cancer sustainability, invasion and metastasis
22500976In this study we have investigated the invasive capacity and matrix remodelling properties of human lung CAFs after exposure to ablative doses of ionizing radiation (AIR), equivalent to single fractions delivered by stereotactic ablative radiotherapy (SART) for medically inoperable stage-I/II non-small-cell lung cancers
22500976METHODS: CAFs were isolated from lung tumour specimens from 16 donors
22500976The migrative and invasive capacities of CAFs were thereafter determined after a sub-lethal single radiation dose of 18 Gy
22500976RESULTS: Exposing CAFs to 1 x 18 Gy resulted in a potent induction of multiple nuclear DDR foci (> 9/cell) with little resolution after 120 h, induced premature cellular senescence and inhibition of the proliferative, migrative and invasive capacity
22500976CONCLUSIONS: Our data indicate that ablative doses of radiation exert advantageous inhibitory effects on the proliferative, migratory and invasive capacity of lung CAFs
22500976The reduced motility of irradiated CAFs might be a consequence of stabilized focal contacts via integrins
18842679Fibroblasts located adjacent to the tumor [cancer-associated fibroblasts (CAFs)] that constitute a large proportion of the cancer-associated stroma facilitate the transformation process
18842679In this study, we compared the biological behavior of CAFs that were isolated from a prostate tumor to their normal-associated fibroblast (NAF) counterparts
18842679CAFs formed more colonies when seeded at low cell density, exhibited a higher proliferation rate and were less prone to contact inhibition
18842679In contrast to the general notion that high levels of alpha-smooth muscle actin serve as a marker for CAFs, we found that prostate CAFs express it at a lower level compared with prostate NAFs
18842679Microarray analysis revealed a set of 161 genes that were altered in CAFs compared with NAFs
18842679We focused on whey acidic protein four-disulfide core domain 1 (WFDC1), a known secreted protease inhibitor, and found it to be downregulated in the CAFs
10708479Isolation of the genomic sequence revealed that the gene covered a segment of 6 kb and spanned 11 exons from the translation initiation site ATG to the termination signal TGA
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