HCSGD entry for TAP1

1. General information

Official gene symbolTAP1
Entrez ID6890
Gene full nametransporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Other gene symbolsABC17 ABCB2 APT1 D6S114E PSF-1 PSF1 RING4 TAP1*0102N TAP1N
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001916Positive regulation of T cell mediated cytotoxicityIBAbiological_process
GO:0002474Antigen processing and presentation of peptide antigen via MHC class ITASbiological_process
GO:0002479Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTASbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIDA IEAmolecular_function
GO:0005739MitochondrionIEAcellular_component
GO:0005743Mitochondrial inner membraneIRDcellular_component
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0005829CytosolNAScellular_component
GO:0005886Plasma membraneIBAcellular_component
GO:0006200ATP catabolic processIBAbiological_process
GO:0006857Oligopeptide transportIBAbiological_process
GO:0006952Defense responseIEAbiological_process
GO:0008152Metabolic processIBAbiological_process
GO:0015197Peptide transporter activityIEA IGI IMPmolecular_function
GO:0015421Oligopeptide-transporting ATPase activityIBAmolecular_function
GO:0015833Peptide transportIBA IMPbiological_process
GO:0016021Integral component of membraneIDA IEAcellular_component
GO:0019060Intracellular transport of viral protein in host cellIMPbiological_process
GO:0019885Antigen processing and presentation of endogenous peptide antigen via MHC class IIMPbiological_process
GO:0030176Integral component of endoplasmic reticulum membraneIDAcellular_component
GO:0035672Oligopeptide transmembrane transportIBAbiological_process
GO:0042288MHC class I protein bindingIBA IEAmolecular_function
GO:0042590Antigen processing and presentation of exogenous peptide antigen via MHC class ITASbiological_process
GO:0042605Peptide antigen bindingIBA NASmolecular_function
GO:0042626ATPase activity, coupled to transmembrane movement of substancesIEAmolecular_function
GO:0042803Protein homodimerization activityISSmolecular_function
GO:0042825TAP complexIBA IDAcellular_component
GO:0043531ADP bindingIDAmolecular_function
GO:0046967Cytosol to ER transportIMPbiological_process
GO:0046978TAP1 bindingIBA ISSmolecular_function
GO:0046979TAP2 bindingIBA IPImolecular_function
GO:0046980Tapasin bindingIBAmolecular_function
GO:0055085Transmembrane transportIBAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01555166600.32854894950.30957416921.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.9328187535
GSE13712_SHEARUp1.1340593853
GSE13712_STATICUp1.4872234513
GSE19018Down-0.4210292573
GSE19899_A1Up0.3073886924
GSE19899_A2Up0.6311917726
PubMed_21979375_A1Up0.4189003192
PubMed_21979375_A2Up1.1027135955
GSE35957Down-0.7758642202
GSE36640Up1.4864939277
GSE54402Down-0.6594328144
GSE9593Down-0.0280231855
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Down-0.0141218409
GSE28863_A2Up0.6608836839
GSE28863_A3Down-1.0553117822
GSE28863_A4Down-0.1444795454
GSE48662Down-0.3668096219

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-346MIMAT0000773MIRT006669Immunocytochemistry//In situ hybridization//qRT-PCR//Western blotFunctional MTI22002058
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.