HCSGD entry for MAP3K7

1. General information

Official gene symbolMAP3K7
Entrez ID6885
Gene full namemitogen-activated protein kinase kinase kinase 7
Other gene symbolsMEKK7 TAK1 TGF1a
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000186Activation of MAPKK activityIDAbiological_process
GO:0000187Activation of MAPK activityIDA TASbiological_process
GO:0000287Magnesium ion bindingIEAmolecular_function
GO:0001525AngiogenesisIEAbiological_process
GO:0001841Neural tube formationIEAbiological_process
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002726Positive regulation of T cell cytokine productionIMPbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0004672Protein kinase activityIDAmolecular_function
GO:0004674Protein serine/threonine kinase activityEXP TASmolecular_function
GO:0004708MAP kinase kinase activityIEAmolecular_function
GO:0004709MAP kinase kinase kinase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005671Ada2/Gcn5/Ada3 transcription activator complexIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006915Apoptotic processIEAbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayIEAbiological_process
GO:0007249I-kappaB kinase/NF-kappaB signalingTASbiological_process
GO:0007250Activation of NF-kappaB-inducing kinase activityIMPbiological_process
GO:0007252I-kappaB phosphorylationIDAbiological_process
GO:0007254JNK cascadeIDA TASbiological_process
GO:0008385IkappaB kinase complexIPIcellular_component
GO:0010008Endosome membraneTAScellular_component
GO:0032743Positive regulation of interleukin-2 productionIMPbiological_process
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0035872Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayTASbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIMPbiological_process
GO:0043507Positive regulation of JUN kinase activityIDA IMPbiological_process
GO:0043966Histone H3 acetylationIDAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0046330Positive regulation of JNK cascadeIEAbiological_process
GO:0050852T cell receptor signaling pathwayNAS TASbiological_process
GO:0050870Positive regulation of T cell activationICbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityTASbiological_process
GO:0051403Stress-activated MAPK cascadeIDA TASbiological_process
GO:0070423Nucleotide-binding oligomerization domain containing signaling pathwayTASbiological_process
GO:2001234Negative regulation of apoptotic signaling pathwayIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.83521688010.20893914740.99999024730.8844174144

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0470444860
GSE13712_SHEARUp0.1047436962
GSE13712_STATICDown-0.1265858042
GSE19018Down-0.2605368677
GSE19899_A1Down-0.4375038227
GSE19899_A2Down-0.1855845034
PubMed_21979375_A1Up0.5112766908
PubMed_21979375_A2Down-0.6006978129
GSE35957Up0.3085070658
GSE36640Up0.1148406660
GSE54402Up0.2807509928
GSE9593Up0.2029320900
GSE43922Down-0.0408227822
GSE24585Down-0.0254882614
GSE37065Down-0.0205196759
GSE28863_A1Up0.0136772562
GSE28863_A2Up0.2767996692
GSE28863_A3Down-0.3975316668
GSE28863_A4Down-0.3721107955
GSE48662Down-0.0407958707

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-10a-5pMIMAT0000253MIRT005509Luciferase reporter assay//Microarray//qRT-PCR//Western blot//Reporter assay;OtherFunctional MTI20624982
hsa-miR-34a-5pMIMAT0000255MIRT025316SequencingFunctional MTI (Weak)20371350
hsa-miR-103a-3pMIMAT0000101MIRT027011SequencingFunctional MTI (Weak)20371350
hsa-miR-1226-5pMIMAT0005576MIRT036539CLASHFunctional MTI (Weak)23622248
hsa-miR-16-5pMIMAT0000069MIRT051235CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25118260Transforming growth factor-beta-activated kinase 1 inhibition led to reduction in cell proliferation, cell-cycle arrest at G0/G1, and increased SA-beta-gal expression, all known to be features of cell senescence
24337384TNFR-associated factor 6 and TGF-beta-activated kinase 1 control signals for a senescence response by an endosomal NK cell receptor
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