HCSGD entry for ADAM17
1. General information
| Official gene symbol | ADAM17 |
|---|---|
| Entrez ID | 6868 |
| Gene full name | ADAM metallopeptidase domain 17 |
| Other gene symbols | ADAM18 CD156B CSVP NISBD TACE |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001666 | Response to hypoxia | IDA | biological_process |
| GO:0001934 | Positive regulation of protein phosphorylation | IMP | biological_process |
| GO:0002446 | Neutrophil mediated immunity | IC | biological_process |
| GO:0002467 | Germinal center formation | ISS | biological_process |
| GO:0002690 | Positive regulation of leukocyte chemotaxis | IC | biological_process |
| GO:0004222 | Metalloendopeptidase activity | IDA IEA IMP TAS | molecular_function |
| GO:0005112 | Notch binding | IDA | molecular_function |
| GO:0005138 | Interleukin-6 receptor binding | IPI | molecular_function |
| GO:0005178 | Integrin binding | IPI | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | IDA | cellular_component |
| GO:0005911 | Cell-cell junction | IDA | cellular_component |
| GO:0005925 | Focal adhesion | IDA | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0006509 | Membrane protein ectodomain proteolysis | IDA IMP | biological_process |
| GO:0006915 | Apoptotic process | TAS | biological_process |
| GO:0007155 | Cell adhesion | IDA | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | IDA TAS | biological_process |
| GO:0007219 | Notch signaling pathway | IEA | biological_process |
| GO:0007220 | Notch receptor processing | IDA | biological_process |
| GO:0008237 | Metallopeptidase activity | IDA IMP TAS | molecular_function |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0008284 | Positive regulation of cell proliferation | IMP | biological_process |
| GO:0009986 | Cell surface | IDA | cellular_component |
| GO:0010820 | Positive regulation of T cell chemotaxis | IMP | biological_process |
| GO:0015629 | Actin cytoskeleton | IDA | cellular_component |
| GO:0016324 | Apical plasma membrane | IDA | cellular_component |
| GO:0017124 | SH3 domain binding | IEA | molecular_function |
| GO:0022617 | Extracellular matrix disassembly | TAS | biological_process |
| GO:0030165 | PDZ domain binding | IPI | molecular_function |
| GO:0030183 | B cell differentiation | ISS | biological_process |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0030307 | Positive regulation of cell growth | IMP | biological_process |
| GO:0030335 | Positive regulation of cell migration | IMP | biological_process |
| GO:0030511 | Positive regulation of transforming growth factor beta receptor signaling pathway | ISS | biological_process |
| GO:0030574 | Collagen catabolic process | TAS | biological_process |
| GO:0031293 | Membrane protein intracellular domain proteolysis | TAS | biological_process |
| GO:0031659 | Positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle | IDA | biological_process |
| GO:0032496 | Response to lipopolysaccharide | IDA | biological_process |
| GO:0032587 | Ruffle membrane | IDA | cellular_component |
| GO:0032717 | Negative regulation of interleukin-8 production | IMP | biological_process |
| GO:0032722 | Positive regulation of chemokine production | IMP | biological_process |
| GO:0033025 | Regulation of mast cell apoptotic process | ISS | biological_process |
| GO:0033077 | T cell differentiation in thymus | ISS | biological_process |
| GO:0033627 | Cell adhesion mediated by integrin | IDA | biological_process |
| GO:0035313 | Wound healing, spreading of epidermal cells | IEP | biological_process |
| GO:0035625 | Epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway | IMP | biological_process |
| GO:0042493 | Response to drug | ISS | biological_process |
| GO:0045121 | Membrane raft | IDA | cellular_component |
| GO:0045741 | Positive regulation of epidermal growth factor-activated receptor activity | IDA IMP | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0048536 | Spleen development | ISS | biological_process |
| GO:0048870 | Cell motility | ISS | biological_process |
| GO:0051088 | PMA-inducible membrane protein ectodomain proteolysis | IDA IMP | biological_process |
| GO:0051272 | Positive regulation of cellular component movement | ISS | biological_process |
| GO:0055099 | Response to high density lipoprotein particle | IDA | biological_process |
| GO:0060397 | JAK-STAT cascade involved in growth hormone signaling pathway | TAS | biological_process |
| GO:0097190 | Apoptotic signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1539681623 | 0.3043542988 | 0.7808470135 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1112682684 |
| GSE13712_SHEAR | Up | 0.2498185168 |
| GSE13712_STATIC | Up | 0.5439385496 |
| GSE19018 | Up | 0.2154659698 |
| GSE19899_A1 | Down | -0.0061495517 |
| GSE19899_A2 | Up | 0.0448300785 |
| PubMed_21979375_A1 | Down | -0.1085636288 |
| PubMed_21979375_A2 | Up | 0.7298399435 |
| GSE35957 | Down | -0.4271436728 |
| GSE36640 | Up | 0.1536695850 |
| GSE54402 | Down | -0.2787260757 |
| GSE9593 | Up | 0.2312620093 |
| GSE43922 | Up | 0.1018365434 |
| GSE24585 | Down | -0.2489411063 |
| GSE37065 | Up | 0.4858613800 |
| GSE28863_A1 | Up | 0.1085961696 |
| GSE28863_A2 | Up | 0.6654637836 |
| GSE28863_A3 | Down | -0.9459374216 |
| GSE28863_A4 | Down | -0.2311028716 |
| GSE48662 | Down | -0.0074857708 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| (3S)-1-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}pyrrolidine-3-thiol | DB06943 | - |
| 3-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}propane-1-thiol | DB07079 | - |
| 4-({4-[(4-AMINOBUT-2-YNYL)OXY]PHENYL}SULFONYL)-N-HYDROXY-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXAMIDE | DB07121 | - |
| (2R)-N-HYDROXY-2-[(3S)-3-METHYL-3-{4-[(2-METHYLQUINOLIN-4-YL)METHOXY]PHENYL}-2-OXOPYRROLIDIN-1-YL]PROPANAMIDE | DB07145 | - |
| methyl (1R,2S)-2-(hydroxycarbamoyl)-1-{4-[(2-methylquinolin-4-yl)methoxy]benzyl}cyclopropanecarboxylate | DB07147 | - |
| (1S,3R,6S)-4-oxo-6-{4-[(2-phenylquinolin-4-yl)methoxy]phenyl}-5-azaspiro[2.4]heptane-1-carboxylic acid | DB07189 | - |
| N-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}-5-methyl-D-tryptophan | DB07233 | - |
| (3S)-4-{[4-(BUT-2-YNYLOXY)PHENYL]SULFONYL}-N-HYDROXY-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXAMIDE | DB07964 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-122-5p | MIMAT0000421 | MIRT003112 | Luciferase reporter assay//qRT-PCR | Functional MTI | 19296470 |
| hsa-miR-122-5p | MIMAT0000421 | MIRT003112 | qRT-PCR | Functional MTI (Weak) | 19726678 |
| hsa-miR-122-5p | MIMAT0000421 | MIRT003112 | Luciferase reporter assay// | Functional MTI | 19935707 |
| hsa-miR-145-5p | MIMAT0000437 | MIRT007275 | Luciferase reporter assay | Functional MTI | 23441135 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26260680 | Role of ADAM17 in the non-cell autonomous effects of oncogene-induced senescence |
| 26260680 | Then, protein and RNA levels of ADAM17 were evaluated by using Western blot and reverse transcription-polymerase chain reaction, its localization by using biotin labeling and immunofluorescence, and its activity by using alkaline phosphatase-tagged substrates |
| 26260680 | The p95HER2-expressing cell lines, senescent MCF7 and proliferating MCF10A, were analyzed to study ADAM17 regulation |
| 26260680 | Finally, we knocked down ADAM17 to determine its contribution to the senescence-associated secretome |
| 26260680 | We determine that these proteins are regulated transcriptionally and, in addition, that their shedding is limited by the protease ADAM17 |
| 26260680 | The blockade of ADAM17 abrogates several prometastatic effects of the p95HER2-induced senescence secretome, both in vitro and in vivo |
| 26260680 | CONCLUSIONS: Considering these findings, we conclude that ectodomain shedding is tightly regulated in oncogene-induced senescent cells by integrating transcription of the shedding substrates with limiting ADAM17 activity |
| 26260680 | The remaining activity of ADAM17 contributes to the non-cell autonomous protumorigenic effects of p95HER2-induced senescent cells |
| 26260680 | Because ADAM17 is druggable, these results represent an approximation to the pharmacological regulation of the senescence secretome |
| 25077560 | Senescence-associated release of transmembrane proteins involves proteolytic processing by ADAM17 and microvesicle shedding |
| 25077560 | Here we show in different models of senescence that the metalloprotease A disintegrin and metalloproteinase 17 (ADAM17) is activated and releases the epidermal growth factor receptor ligand amphiregulin and tumor necrosis factor receptor I (TNFRI) from the surface of senescent cells by ectodomain shedding |
| 25077560 | Interestingly, unlike amphiregulin and TNFRI, full-length intercellular adhesion molecule 1 (ICAM1) is released from senescent cells by microvesicles independently of ADAM17 |
| 25077560 | Thus, our results suggest that transmembrane proteins can be released by two distinct mechanisms and point to a crucial role for ADAM17 in shaping the secretory profile of senescent cells |
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