HCSGD entry for SYK


1. General information

Official gene symbolSYK
Entrez ID6850
Gene full namespleen tyrosine kinase
Other gene symbolsp72-Syk
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001525AngiogenesisIEAbiological_process
GO:0001945Lymph vessel developmentISSbiological_process
GO:0002250Adaptive immune responseISSbiological_process
GO:0002281Macrophage activation involved in immune responseISSbiological_process
GO:0002283Neutrophil activation involved in immune responseISSbiological_process
GO:0002366Leukocyte activation involved in immune responseISSbiological_process
GO:0002554Serotonin secretion by plateletISSbiological_process
GO:0004672Protein kinase activityNASmolecular_function
GO:0004713Protein tyrosine kinase activityEXP TASmolecular_function
GO:0004715Non-membrane spanning protein tyrosine kinase activityIDA TASmolecular_function
GO:0004716Receptor signaling protein tyrosine kinase activityIEAmolecular_function
GO:0005178Integrin bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005829CytosolIC TAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006468Protein phosphorylationISSbiological_process
GO:0007159Leukocyte cell-cell adhesionIDAbiological_process
GO:0007167Enzyme linked receptor protein signaling pathwayIEAbiological_process
GO:0007229Integrin-mediated signaling pathwayISS NASbiological_process
GO:0007257Activation of JUN kinase activityIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008283Cell proliferationTASbiological_process
GO:0009887Organ morphogenesisTASbiological_process
GO:0010543Regulation of platelet activationISSbiological_process
GO:0016032Viral processIEAbiological_process
GO:0019370Leukotriene biosynthetic processIEAbiological_process
GO:0019815B cell receptor complexIEAcellular_component
GO:0019901Protein kinase bindingIEAmolecular_function
GO:0030168Platelet activationTASbiological_process
GO:0030593Neutrophil chemotaxisIDAbiological_process
GO:0032009Early phagosomeISScellular_component
GO:0032928Regulation of superoxide anion generationISSbiological_process
GO:0033630Positive regulation of cell adhesion mediated by integrinISSbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosisTASbiological_process
GO:0042101T cell receptor complexIDAcellular_component
GO:0042742Defense response to bacteriumISSbiological_process
GO:0043306Positive regulation of mast cell degranulationIEAbiological_process
GO:0043313Regulation of neutrophil degranulationISSbiological_process
GO:0043366Beta selectionIEAbiological_process
GO:0045087Innate immune responseISS TASbiological_process
GO:0045401Positive regulation of interleukin-3 biosynthetic processIEAbiological_process
GO:0045425Positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic processIEAbiological_process
GO:0045579Positive regulation of B cell differentiationIEAbiological_process
GO:0045588Positive regulation of gamma-delta T cell differentiationIEAbiological_process
GO:0045780Positive regulation of bone resorptionISSbiological_process
GO:0046638Positive regulation of alpha-beta T cell differentiationIEAbiological_process
GO:0046641Positive regulation of alpha-beta T cell proliferationIEAbiological_process
GO:0046777Protein autophosphorylationIEAbiological_process
GO:0048514Blood vessel morphogenesisISSbiological_process
GO:0050715Positive regulation of cytokine secretionIEAbiological_process
GO:0050731Positive regulation of peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0050764Regulation of phagocytosisISSbiological_process
GO:0050850Positive regulation of calcium-mediated signalingIEAbiological_process
GO:0050853B cell receptor signaling pathwayISSbiological_process
GO:0070372Regulation of ERK1 and ERK2 cascadeISSbiological_process
GO:0071226Cellular response to molecule of fungal originISSbiological_process
GO:0090237Regulation of arachidonic acid secretionISSbiological_process
GO:0090330Regulation of platelet aggregationISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.78532993050.88910369670.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0131505324
GSE13712_SHEARUp0.0127950534
GSE13712_STATICUp0.1864794671
GSE19018Up0.0972618751
GSE19899_A1Up0.0705379027
GSE19899_A2Down-0.0075295652
PubMed_21979375_A1Down-0.0226924243
PubMed_21979375_A2Up0.0218846088
GSE35957Up0.1472203186
GSE36640Down-0.0305226094
GSE54402Down-0.0576273089
GSE9593Down-0.0210332321
GSE43922Up0.0212561550
GSE24585Up0.0146207266
GSE37065Up0.0384235309
GSE28863_A1Down-0.1037831127
GSE28863_A2Down-0.0589566421
GSE28863_A3Up0.2060783542
GSE28863_A4Up0.1017835505
GSE48662Down-0.0579073746

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

StaurosporineDB02010 EXPT02970 | EXPT02972
N-(2-hydroxy-1,1-dimethylethyl)-1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-indole-5-carboxamideDB06834 -
6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-oneDB07159 -
2-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamideDB07194 -
2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamideDB08361 -
Ellagic AcidDB08846 DB08468

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-99b-3pMIMAT0004678MIRT038521CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT040474CLASHFunctional MTI (Weak)23622248
hsa-miR-331-3pMIMAT0000760MIRT043443CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23801923Cellular senescence or oxidative damage induces a cascade of biochemical events that results in the detachment of band 3 from the cytoskeleton and in clustering of band 3 protein by bound hemichromes and Syk kinase
22202644A novel target of early ultraviolet-induced skin photodamage, the Syk kinase, has been recently identified
19293188Spleen tyrosine kinase functions as a tumor suppressor in melanoma cells by inducing senescence-like growth arrest
19293188Spleen tyrosine kinase (Syk) is a cytoplasmic tyrosine kinase that has been recently implicated in tumor suppression of melanoma, a deadly skin cancer derived from pigment-producing melanocytes
19293188However, the mechanism by which Syk suppresses melanoma growth remains unclear
19293188Here, we report that reexpression of Syk in melanoma cells induces a p53-dependent expression of the cyclin-dependent kinase (cdk) inhibitor p21 and a senescence program
19293188We first observed that Syk expression is lost in a subset of melanoma cell lines, primarily by DNA methylation-mediated gene silencing and restored after treatment with the demethylating agent 5-aza-2-deoxycytidine
19293188We analyzed the significance of epigenetic inactivation of Syk and found that reintroduction of Syk in melanoma cells dramatically reduces clonogenic survival and three-dimensional tumor spheroid growth and invasion
19293188Remarkably, melanoma cells reexpressing Syk display hallmarks of senescent cells, including reduction of proliferative activity and DNA synthesis, large and flattened morphology, senescence-associated beta-galactosidase activity, and heterochromatic foci
19293188Our results highlight a new role for Syk tyrosine kinase in regulating cellular senescence and identify Syk-mediated senescence as a novel tumor suppressor pathway the inactivation of which may contribute to melanoma tumorigenicity
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