HCSGD entry for SYK
1. General information
Official gene symbol | SYK |
---|---|
Entrez ID | 6850 |
Gene full name | spleen tyrosine kinase |
Other gene symbols | p72-Syk |
Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network

This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
---|---|---|---|
GO:0001525 | Angiogenesis | IEA | biological_process |
GO:0001945 | Lymph vessel development | ISS | biological_process |
GO:0002250 | Adaptive immune response | ISS | biological_process |
GO:0002281 | Macrophage activation involved in immune response | ISS | biological_process |
GO:0002283 | Neutrophil activation involved in immune response | ISS | biological_process |
GO:0002366 | Leukocyte activation involved in immune response | ISS | biological_process |
GO:0002554 | Serotonin secretion by platelet | ISS | biological_process |
GO:0004672 | Protein kinase activity | NAS | molecular_function |
GO:0004713 | Protein tyrosine kinase activity | EXP TAS | molecular_function |
GO:0004715 | Non-membrane spanning protein tyrosine kinase activity | IDA TAS | molecular_function |
GO:0004716 | Receptor signaling protein tyrosine kinase activity | IEA | molecular_function |
GO:0005178 | Integrin binding | IPI | molecular_function |
GO:0005515 | Protein binding | IPI | molecular_function |
GO:0005524 | ATP binding | IEA | molecular_function |
GO:0005829 | Cytosol | IC TAS | cellular_component |
GO:0005886 | Plasma membrane | TAS | cellular_component |
GO:0006468 | Protein phosphorylation | ISS | biological_process |
GO:0007159 | Leukocyte cell-cell adhesion | IDA | biological_process |
GO:0007167 | Enzyme linked receptor protein signaling pathway | IEA | biological_process |
GO:0007229 | Integrin-mediated signaling pathway | ISS NAS | biological_process |
GO:0007257 | Activation of JUN kinase activity | IEA | biological_process |
GO:0007596 | Blood coagulation | TAS | biological_process |
GO:0008283 | Cell proliferation | TAS | biological_process |
GO:0009887 | Organ morphogenesis | TAS | biological_process |
GO:0010543 | Regulation of platelet activation | ISS | biological_process |
GO:0016032 | Viral process | IEA | biological_process |
GO:0019370 | Leukotriene biosynthetic process | IEA | biological_process |
GO:0019815 | B cell receptor complex | IEA | cellular_component |
GO:0019901 | Protein kinase binding | IEA | molecular_function |
GO:0030168 | Platelet activation | TAS | biological_process |
GO:0030593 | Neutrophil chemotaxis | IDA | biological_process |
GO:0032009 | Early phagosome | ISS | cellular_component |
GO:0032928 | Regulation of superoxide anion generation | ISS | biological_process |
GO:0033630 | Positive regulation of cell adhesion mediated by integrin | ISS | biological_process |
GO:0038095 | Fc-epsilon receptor signaling pathway | TAS | biological_process |
GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | TAS | biological_process |
GO:0042101 | T cell receptor complex | IDA | cellular_component |
GO:0042742 | Defense response to bacterium | ISS | biological_process |
GO:0043306 | Positive regulation of mast cell degranulation | IEA | biological_process |
GO:0043313 | Regulation of neutrophil degranulation | ISS | biological_process |
GO:0043366 | Beta selection | IEA | biological_process |
GO:0045087 | Innate immune response | ISS TAS | biological_process |
GO:0045401 | Positive regulation of interleukin-3 biosynthetic process | IEA | biological_process |
GO:0045425 | Positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process | IEA | biological_process |
GO:0045579 | Positive regulation of B cell differentiation | IEA | biological_process |
GO:0045588 | Positive regulation of gamma-delta T cell differentiation | IEA | biological_process |
GO:0045780 | Positive regulation of bone resorption | ISS | biological_process |
GO:0046638 | Positive regulation of alpha-beta T cell differentiation | IEA | biological_process |
GO:0046641 | Positive regulation of alpha-beta T cell proliferation | IEA | biological_process |
GO:0046777 | Protein autophosphorylation | IEA | biological_process |
GO:0048514 | Blood vessel morphogenesis | ISS | biological_process |
GO:0050715 | Positive regulation of cytokine secretion | IEA | biological_process |
GO:0050731 | Positive regulation of peptidyl-tyrosine phosphorylation | IEA | biological_process |
GO:0050764 | Regulation of phagocytosis | ISS | biological_process |
GO:0050850 | Positive regulation of calcium-mediated signaling | IEA | biological_process |
GO:0050853 | B cell receptor signaling pathway | ISS | biological_process |
GO:0070372 | Regulation of ERK1 and ERK2 cascade | ISS | biological_process |
GO:0071226 | Cellular response to molecule of fungal origin | ISS | biological_process |
GO:0090237 | Regulation of arachidonic acid secretion | ISS | biological_process |
GO:0090330 | Regulation of platelet aggregation | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
p-value up | p-value down | FDR up | FDR down |
---|---|---|---|
0.7853299305 | 0.8891036967 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
Data source | Up or down | Log fold change |
---|---|---|
GSE11954 | Down | -0.0131505324 |
GSE13712_SHEAR | Up | 0.0127950534 |
GSE13712_STATIC | Up | 0.1864794671 |
GSE19018 | Up | 0.0972618751 |
GSE19899_A1 | Up | 0.0705379027 |
GSE19899_A2 | Down | -0.0075295652 |
PubMed_21979375_A1 | Down | -0.0226924243 |
PubMed_21979375_A2 | Up | 0.0218846088 |
GSE35957 | Up | 0.1472203186 |
GSE36640 | Down | -0.0305226094 |
GSE54402 | Down | -0.0576273089 |
GSE9593 | Down | -0.0210332321 |
GSE43922 | Up | 0.0212561550 |
GSE24585 | Up | 0.0146207266 |
GSE37065 | Up | 0.0384235309 |
GSE28863_A1 | Down | -0.1037831127 |
GSE28863_A2 | Down | -0.0589566421 |
GSE28863_A3 | Up | 0.2060783542 |
GSE28863_A4 | Up | 0.1017835505 |
GSE48662 | Down | -0.0579073746 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
---|---|---|
Staurosporine | DB02010 | EXPT02970 | EXPT02972 |
N-(2-hydroxy-1,1-dimethylethyl)-1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-indole-5-carboxamide | DB06834 | - |
6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one | DB07159 | - |
2-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide | DB07194 | - |
2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide | DB08361 | - |
Ellagic Acid | DB08846 | DB08468 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
---|---|---|---|---|---|
hsa-miR-99b-3p | MIMAT0004678 | MIRT038521 | CLASH | Functional MTI (Weak) | 23622248 |
hsa-miR-615-3p | MIMAT0003283 | MIRT040474 | CLASH | Functional MTI (Weak) | 23622248 |
hsa-miR-331-3p | MIMAT0000760 | MIRT043443 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
---|---|
23801923 | Cellular senescence or oxidative damage induces a cascade of biochemical events that results in the detachment of band 3 from the cytoskeleton and in clustering of band 3 protein by bound hemichromes and Syk kinase |
22202644 | A novel target of early ultraviolet-induced skin photodamage, the Syk kinase, has been recently identified |
19293188 | Spleen tyrosine kinase functions as a tumor suppressor in melanoma cells by inducing senescence-like growth arrest |
19293188 | Spleen tyrosine kinase (Syk) is a cytoplasmic tyrosine kinase that has been recently implicated in tumor suppression of melanoma, a deadly skin cancer derived from pigment-producing melanocytes |
19293188 | However, the mechanism by which Syk suppresses melanoma growth remains unclear |
19293188 | Here, we report that reexpression of Syk in melanoma cells induces a p53-dependent expression of the cyclin-dependent kinase (cdk) inhibitor p21 and a senescence program |
19293188 | We first observed that Syk expression is lost in a subset of melanoma cell lines, primarily by DNA methylation-mediated gene silencing and restored after treatment with the demethylating agent 5-aza-2-deoxycytidine |
19293188 | We analyzed the significance of epigenetic inactivation of Syk and found that reintroduction of Syk in melanoma cells dramatically reduces clonogenic survival and three-dimensional tumor spheroid growth and invasion |
19293188 | Remarkably, melanoma cells reexpressing Syk display hallmarks of senescent cells, including reduction of proliferative activity and DNA synthesis, large and flattened morphology, senescence-associated beta-galactosidase activity, and heterochromatic foci |
19293188 | Our results highlight a new role for Syk tyrosine kinase in regulating cellular senescence and identify Syk-mediated senescence as a novel tumor suppressor pathway the inactivation of which may contribute to melanoma tumorigenicity |
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