HCSGD entry for STK11

1. General information

Official gene symbolSTK11
Entrez ID6794
Gene full nameserine/threonine kinase 11
Other gene symbolsLKB1 PJS hLKB1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000287Magnesium ion bindingIDAmolecular_function
GO:0001558Regulation of cell growthISSbiological_process
GO:0001894Tissue homeostasisIEAbiological_process
GO:0001944Vasculature developmentISSbiological_process
GO:0002039P53 bindingIDAmolecular_function
GO:0004672Protein kinase activityIEAmolecular_function
GO:0004674Protein serine/threonine kinase activityIDA IEA TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIDA IEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIDAcellular_component
GO:0005829CytosolISS TAScellular_component
GO:0006112Energy reserve metabolic processTASbiological_process
GO:0006468Protein phosphorylationIDAbiological_process
GO:0006914AutophagyIEAbiological_process
GO:0006974Cellular response to DNA damage stimulusIEAbiological_process
GO:0007050Cell cycle arrestIDA TASbiological_process
GO:0007286Spermatid developmentIEAbiological_process
GO:0007409AxonogenesisIEAbiological_process
GO:0008285Negative regulation of cell proliferationIMPbiological_process
GO:0008286Insulin receptor signaling pathwayTASbiological_process
GO:0010212Response to ionizing radiationISSbiological_process
GO:0016020MembraneISScellular_component
GO:0030010Establishment of cell polarityISSbiological_process
GO:0030111Regulation of Wnt signaling pathwayIEAbiological_process
GO:0030275LRR domain bindingIEAmolecular_function
GO:0030295Protein kinase activator activityIDAmolecular_function
GO:0030308Negative regulation of cell growthISSbiological_process
GO:0030511Positive regulation of transforming growth factor beta receptor signaling pathwayIMPbiological_process
GO:0032147Activation of protein kinase activityIDA IEAbiological_process
GO:0032403Protein complex bindingIEAmolecular_function
GO:0033762Response to glucagonIEAbiological_process
GO:0033993Response to lipidIEAbiological_process
GO:0036398TCR signalosomeIEAcellular_component
GO:0036399TCR signalosome assemblyIEAbiological_process
GO:0042304Regulation of fatty acid biosynthetic processTASbiological_process
GO:0042593Glucose homeostasisISSbiological_process
GO:0043276AnoikisIMPbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045059Positive thymic T cell selectionIEAbiological_process
GO:0045722Positive regulation of gluconeogenesisIEAbiological_process
GO:0046777Protein autophosphorylationIDAbiological_process
GO:0050731Positive regulation of peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0050772Positive regulation of axonogenesisIEAbiological_process
GO:0050852T cell receptor signaling pathwayIEAbiological_process
GO:0051291Protein heterooligomerizationIEAbiological_process
GO:0051645Golgi localizationIEAbiological_process
GO:0051896Regulation of protein kinase B signalingIEAbiological_process
GO:0060070Canonical Wnt signaling pathwayIEAbiological_process
GO:0060770Negative regulation of epithelial cell proliferation involved in prostate gland developmentIEAbiological_process
GO:0072332Intrinsic apoptotic signaling pathway by p53 class mediatorIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.74714386230.70121360890.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0411252157
GSE13712_SHEARDown-0.0579173826
GSE13712_STATICDown-0.1022856691
GSE19018Up0.2881867414
GSE19899_A1Down-0.0389280031
GSE19899_A2Up0.1374857131
PubMed_21979375_A1Down-0.1636657498
PubMed_21979375_A2Up0.0769659029
GSE35957Down-0.1307295187
GSE36640Down-0.0481079118
GSE54402Up0.0567961677
GSE9593Up0.0060831788
GSE43922Up0.0294628471
GSE24585Down-0.1042348705
GSE37065Down-0.2060470789
GSE28863_A1Up0.0690423117
GSE28863_A2Down-0.1083320090
GSE28863_A3Down-0.0765233344
GSE28863_A4Up0.1482284907
GSE48662Up0.4441345652

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-130b-3pMIMAT0000691MIRT020252SequencingFunctional MTI (Weak)20371350
hsa-miR-93-5pMIMAT0000093MIRT028122SequencingFunctional MTI (Weak)20371350
hsa-miR-17-5pMIMAT0000070MIRT050817CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27259994Endothelial SIRT1 prevents adverse arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1
27259994By decreasing LKB1 protein levels, it promotes the survival and regeneration of endothelial cells
27259994The present study aims to investigate the molecular mechanisms underlying SIRT1-mediated LKB1 degradation for the prevention of vascular ageing
27259994Methods and Results-Co-immunoprecipitation assay demonstrated that SIRT1, via its amino-terminus, binds to the DOC domain of HERC2 [HECT and RLD domain containing E3 ubiquitin protein ligase 2], which then ubiquitinates LKB1 in the nuclear compartment of endothelial cells
27259994Site-directed mutagenesis revealed that acetylation at lysine (K) 64 of LKB1 triggers the formation of SIRT1/HERC2/LKB1 protein complex and subsequent proteasomal degradation
27259994In vitro cellular studies suggested that accumulation of acetylated LKB1 in the nucleus leads to endothelial activation, in turn stimulating the proliferation of vascular smooth muscle cells and the production of extracellular matrix proteins
27259994Chromatin immunoprecipitation quantitative PCR confirmed that acetylated LKB1 interacts with and activates TGFbeta1 promoter, which is inhibited by SIRT1
27259994Knocking down either SIRT1 or HERC2 results in an increased association of LKB1 with the positive regulatory elements of TGFbeta1 promoter
27259994Conclusion-By downregulating acetylated LKB1 protein via HERC2, SIRT1 fine-tunes the crosstalk between endothelial and vascular smooth muscle cells to prevent adverse arterial remodeling and maintain vascular homeostasis
26443543Similarly, two stilbenes also stimulated LKB1, AMPKalpha, extracellular-signal related kinase 5 (ERK5) phosphorylation, and histone acetylase 5 (HDAC5) and Kruppel-like factor 2 (KLF2) expression
21317932Here we showed that in the presence of wild-type LKB1, NUAK1 directly interacts with and phosphorylates p53 in vitro and in vivo
21317932The phosphorylation of p53 induced by LKB1 required the kinase activity of NUAK1 and phosphorylation of NUAK1 at Thr211 by LKB1 was essential for its kinase activity, which leads to the conclusion that LKB1 activates NUAK1 and regulates phosphorylation of p53 through the NUAK1 kinase, at least partially
21317932LKB1/NUAK1 activation leads to cell cycle arrest at the G(1)/S border by inducing expression of p21/WAF1
21317932Under the regulation of LKB1, NUAK1 interacts with p53 in the nucleus and binds to the p53-responsive element of p21/WAF1 promoter
20203304SIRT1 promotes proliferation and prevents senescence through targeting LKB1 in primary porcine aortic endothelial cells
20203304In contrast, the protein levels of LKB1, a serine/threonine kinase and tumor suppressor, and the phosphorylation of its downstream target AMPK(Thr172) were dramatically increased in senescent cells
20203304Knocking down of SIRT1 induced senescence and elevated the protein levels of LKB1 and phosphorylated AMPK(Thr172)
20203304CONCLUSIONS: SIRT1 and LKB1/AMPK are the 2 key sensor systems for regulating endothelial cell survival, proliferation and senescence
20203304The protective activities of SIRT1 may be achieved at least in part by fine tuning the acetylation/deacetylation status and stabilities of LKB1 protein
18353141Loci with established importance in melanoma, like CDKN2A, BRAF and PTEN, have been joined by some less familiar genes including transcription factor sequences TBX2 and STK11 (LKB)
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