HCSGD entry for AURKA

1. General information

Official gene symbolAURKA
Entrez ID6790
Gene full nameaurora kinase A
Other gene symbolsAIK ARK1 AURA AURORA2 BTAK PPP1R47 STK15 STK6 STK7
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000278Mitotic cell cycleIEA TASbiological_process
GO:0004672Protein kinase activityIDA IEAmolecular_function
GO:0004674Protein serine/threonine kinase activityIEAmolecular_function
GO:0004712Protein serine/threonine/tyrosine kinase activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005813CentrosomeIDA TAScellular_component
GO:0005819SpindleTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0005876Spindle microtubuleIDAcellular_component
GO:0006468Protein phosphorylationIDAbiological_process
GO:0007049Cell cycleNASbiological_process
GO:0007051Spindle organizationNASbiological_process
GO:0007067MitosisIEAbiological_process
GO:0019901Protein kinase bindingIPImolecular_function
GO:0030030Cell projection organizationIEAbiological_process
GO:0030496MidbodyTAScellular_component
GO:0031145Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processTASbiological_process
GO:0031616Spindle pole centrosomeIDAcellular_component
GO:0031625Ubiquitin protein ligase bindingIEAmolecular_function
GO:0031647Regulation of protein stabilityIMPbiological_process
GO:0032091Negative regulation of protein bindingIDAbiological_process
GO:0043146Spindle stabilizationIMPbiological_process
GO:0045840Positive regulation of mitosisTASbiological_process
GO:0046605Regulation of centrosome cycleTASbiological_process
GO:0046777Protein autophosphorylationTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingNASbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.98777639150.00011567950.99999024730.0193120253

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.8745079907
GSE13712_SHEARUp0.2079888923
GSE13712_STATICUp0.0464049481
GSE19018Down-0.9670965547
GSE19899_A1Down-1.2794860610
GSE19899_A2Down-1.5249158108
PubMed_21979375_A1Down-0.1575816243
PubMed_21979375_A2Down-2.0128050701
GSE35957Down-2.2322665570
GSE36640Down-2.1670366852
GSE54402Down-0.4347154709
GSE9593Down-1.6151507161
GSE43922Down-0.5798220848
GSE24585Down-0.1942772404
GSE37065Down-0.5563730669
GSE28863_A1Down-0.3451549066
GSE28863_A2Up0.5762818686
GSE28863_A3Down-0.7649810649
GSE28863_A4Up0.2000019004
GSE48662Down-2.1270288646

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

PhosphonothreonineDB02482 EXPT03092
AT9283DB05169 -
CYC116DB05198 -
MLN8237DB05220 -
4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDEDB07186 -
8-ethyl-3,10,10-trimethyl-4,5,6,8,10,12-hexahydropyrazolo[4',3':6,7]cyclohepta[1,2-b]pyrrolo[2,3-f]indol-9(1H)-oneDB07266 -
1-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}-3-[3-(trifluoromethyl)phenyl]ureaDB07360 -
1-(3-chlorophenyl)-3-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}ureaDB07361 -
1-(5-{2-[(1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)amino]ethyl}-1,3-thiazol-2-yl)-3-[3-(trifluoromethyl)phenyl]ureaDB07362 -
N-{3-[(4-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-2-YL)AMINO]PHENYL}CYCLOPROPANECARBOXAMIDEDB07545 -
N-butyl-3-{[6-(9H-purin-6-ylamino)hexanoyl]amino}benzamideDB07801 -
2-(1H-pyrazol-3-yl)-1H-benzimidazoleDB08065 -
N-[3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRAZOL-4-YL]BENZAMIDEDB08066 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-let-7b-5pMIMAT0000063MIRT005051MicroarrayFunctional MTI (Weak)17699775
hsa-let-7b-5pMIMAT0000063MIRT005051ProteomicsFunctional MTI (Weak)18668040
hsa-miR-155-5pMIMAT0000646MIRT020589ProteomicsFunctional MTI (Weak)18668040
hsa-miR-124-3pMIMAT0000422MIRT022391Proteomics;MicroarrayFunctional MTI (Weak)18668037
hsa-miR-193a-3pMIMAT0000459MIRT044891CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 6 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26719346METHODS: Tumor senescence was induced by AURKA or CDK4/6 inhibitors (AURKAi, CDK4/6i)
26152738EXPERIMENTAL DESIGN: We combined treatment with an aurora kinase A inhibitor, MLN8237, with agents that activate death receptors (Apo2L/TRAIL or death receptor 5 agonists) and monitored the ability of this treatment to induce tumor apoptosis and melanoma tumor regression using human cell lines and patient-derived xenograft (PDX) mouse models
26152738Mechanistic analysis showed that the induction of tumor cell senescence in response to the AURKA inhibitor resulted in a decreased display of Apo2L/TRAIL decoy receptors and increased display of one Apo2L/TRAIL receptor (death receptor 5), resulting in enhanced response to death receptor ligand/agonists
25758253The primary goal of this study was to evaluate the efficacy of targeting Aurora kinase A (AurA), a key regulator of mitosis, in TNBC models
25398437Here, we show how combining a senescence-inducing inhibitor of the mitotic kinase Aurora A (AURKA) with an MDM2 antagonist activates p53 in senescent tumors harboring wild-type 53
25398437The AURKA/MDM2 combination therapy shows adequate bioavailability and low toxicity to the host
25398437Moreover, the prominent response of patient-derived melanoma tumors to coadministered MDM2 and AURKA inhibitors offers a sound rationale for clinical evaluation
24879067Differential sensitivity of Glioma stem cells to Aurora kinase A inhibitors: implications for stem cell mitosis and centrosome dynamics
21047732Expression profiles of time series after OTX2 induction in MED8A showed early upregulation of cell cycle genes related to the G(2)-M phase, such as AURKA, CDC25C, and CCNG2
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