HCSGD entry for STK3
1. General information
| Official gene symbol | STK3 |
|---|---|
| Entrez ID | 6788 |
| Gene full name | serine/threonine kinase 3 |
| Other gene symbols | KRS1 MST2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000287 | Magnesium ion binding | IDA | molecular_function |
| GO:0001841 | Neural tube formation | IEA | biological_process |
| GO:0003157 | Endocardium development | IEA | biological_process |
| GO:0004672 | Protein kinase activity | IEA TAS | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | EXP IDA IEA | molecular_function |
| GO:0004702 | Receptor signaling protein serine/threonine kinase activity | IBA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IDA IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0006915 | Apoptotic process | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007417 | Central nervous system development | IEA | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | IEA | biological_process |
| GO:0023014 | Signal transduction by phosphorylation | IBA | biological_process |
| GO:0035329 | Hippo signaling | IDA IEA TAS | biological_process |
| GO:0035556 | Intracellular signal transduction | IDA | biological_process |
| GO:0042325 | Regulation of phosphorylation | TAS | biological_process |
| GO:0042327 | Positive regulation of phosphorylation | TAS | biological_process |
| GO:0043065 | Positive regulation of apoptotic process | ISS | biological_process |
| GO:0043085 | Positive regulation of catalytic activity | TAS | biological_process |
| GO:0043539 | Protein serine/threonine kinase activator activity | TAS | molecular_function |
| GO:0045859 | Regulation of protein kinase activity | TAS | biological_process |
| GO:0045860 | Positive regulation of protein kinase activity | TAS | biological_process |
| GO:0046330 | Positive regulation of JNK cascade | IEA | biological_process |
| GO:0046621 | Negative regulation of organ growth | IEA | biological_process |
| GO:0046983 | Protein dimerization activity | ISS | molecular_function |
| GO:0050790 | Regulation of catalytic activity | TAS | biological_process |
| GO:0051897 | Positive regulation of protein kinase B signaling | IEA | biological_process |
| GO:0060215 | Primitive hemopoiesis | IEA | biological_process |
| GO:0060706 | Cell differentiation involved in embryonic placenta development | IEA | biological_process |
| GO:0071902 | Positive regulation of protein serine/threonine kinase activity | TAS | biological_process |
| GO:0090090 | Negative regulation of canonical Wnt signaling pathway | IEA IMP | biological_process |
| GO:0097284 | Hepatocyte apoptotic process | IEA | biological_process |
| GO:1902043 | Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3904180844 | 0.2111697238 | 0.9999902473 | 0.8869892965 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1618361921 |
| GSE13712_SHEAR | Up | 0.3039032199 |
| GSE13712_STATIC | Up | 0.0026691138 |
| GSE19018 | Up | 0.6523706118 |
| GSE19899_A1 | Down | -0.5154329798 |
| GSE19899_A2 | Down | -0.4955551606 |
| PubMed_21979375_A1 | Down | -0.4377254337 |
| PubMed_21979375_A2 | Down | -0.5051219682 |
| GSE35957 | Down | -0.2565773381 |
| GSE36640 | Up | 0.0658780256 |
| GSE54402 | Up | 0.1098492926 |
| GSE9593 | Up | 0.1027945218 |
| GSE43922 | Down | -0.2834366974 |
| GSE24585 | Up | 0.2307386525 |
| GSE37065 | Up | 0.0204732950 |
| GSE28863_A1 | Up | 0.3263281436 |
| GSE28863_A2 | Up | 0.1292413976 |
| GSE28863_A3 | Down | -0.1834397569 |
| GSE28863_A4 | Up | 0.0993281659 |
| GSE48662 | Up | 0.0125023393 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-141-3p | MIMAT0000432 | MIRT001813 | Luciferase reporter assay//Reporter assay;Other | Non-Functional MTI | 15131085 |
| hsa-miR-9-5p | MIMAT0000441 | MIRT021330 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-128-3p | MIMAT0000424 | MIRT021938 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024880 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026447 | Microarray | Functional MTI (Weak) | 19074876 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
