HCSGD entry for SULT1E1
1. General information
| Official gene symbol | SULT1E1 |
|---|---|
| Entrez ID | 6783 |
| Gene full name | sulfotransferase family 1E, estrogen-preferring, member 1 |
| Other gene symbols | EST EST-1 ST1E1 STE |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004304 | Estrone sulfotransferase activity | IEA | molecular_function |
| GO:0005496 | Steroid binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006805 | Xenobiotic metabolic process | TAS | biological_process |
| GO:0007565 | Female pregnancy | IEA | biological_process |
| GO:0008146 | Sulfotransferase activity | IEA | molecular_function |
| GO:0008202 | Steroid metabolic process | TAS | biological_process |
| GO:0008210 | Estrogen metabolic process | IDA | biological_process |
| GO:0031965 | Nuclear membrane | IDA | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0047894 | Flavonol 3-sulfotransferase activity | IDA | molecular_function |
| GO:0050294 | Steroid sulfotransferase activity | IDA TAS | molecular_function |
| GO:0050427 | 3'-phosphoadenosine 5'-phosphosulfate metabolic process | TAS | biological_process |
| GO:0051923 | Sulfation | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7559608450 | 0.0880036587 | 0.9999902473 | 0.5626291717 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.0539143800 |
| GSE13712_SHEAR | Down | -3.1338300687 |
| GSE13712_STATIC | Down | -2.4587404895 |
| GSE19018 | Up | 0.2317287485 |
| GSE19899_A1 | Up | 0.1636479491 |
| GSE19899_A2 | Up | 0.0856192503 |
| PubMed_21979375_A1 | Up | 0.0485213329 |
| PubMed_21979375_A2 | Down | -0.0272303997 |
| GSE35957 | Up | 0.1449527601 |
| GSE36640 | Down | -0.0003500873 |
| GSE54402 | Up | 0.0954083455 |
| GSE9593 | Down | -0.0135667822 |
| GSE43922 | Up | 0.0968054276 |
| GSE24585 | Up | 0.0649674561 |
| GSE37065 | Up | 0.0667584627 |
| GSE28863_A1 | Up | 0.0601519012 |
| GSE28863_A2 | Up | 0.0003867142 |
| GSE28863_A3 | Up | 0.1091483390 |
| GSE28863_A4 | Down | -0.0504303503 |
| GSE48662 | Up | 0.0359426142 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Adenosine-3'-5'-Diphosphate | DB01812 | EXPT00370 |
| 3'-Phosphate-Adenosine-5'-Phosphate Sulfate | DB02902 | EXPT02647 |
| 3,5,3',5'-Tetrachloro-Biphenyl-4,4'-Diol | DB03346 | EXPT02524 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-199a-5p | MIMAT0000231 | MIRT007036 | Luciferase reporter assay | Functional MTI | 23060436 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022279 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 18157152 | Interactions between Est1 and Trt1, the two known protein components of fission yeast telomerase, were dependent on TER1, supporting its role as a scaffold for the assembly of protein subunits |
| 12676088 | Telomere maintenance in fission yeast requires an Est1 ortholog |
| 12676088 | Coupled with the identification of an orthologous Est1 protein in humans [10], this suggests a much wider conservation of telomerase regulation than was previously known |
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