HCSGD entry for STAT5B

1. General information

Official gene symbolSTAT5B
Entrez ID6777
Gene full namesignal transducer and activator of transcription 5B
Other gene symbolsSTAT5
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000255Allantoin metabolic processIEA ISSbiological_process
GO:0000979RNA polymerase II core promoter sequence-specific DNA bindingIEAmolecular_function
GO:0001553LuteinizationIEAbiological_process
GO:0001666Response to hypoxiaIEAbiological_process
GO:0001779Natural killer cell differentiationIEAbiological_process
GO:0001889Liver developmentIEAbiological_process
GO:0003682Chromatin bindingISSmolecular_function
GO:0003690Double-stranded DNA bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0004871Signal transducer activityIEAmolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEA ISScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmISScellular_component
GO:0005829CytosolIEA TAScellular_component
GO:0006101Citrate metabolic processIEA ISSbiological_process
GO:00061032-oxoglutarate metabolic processIEA ISSbiological_process
GO:0006105Succinate metabolic processIEA ISSbiological_process
GO:0006107Oxaloacetate metabolic processIEA ISSbiological_process
GO:0006357Regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0006366Transcription from RNA polymerase II promoterIEAbiological_process
GO:0006549Isoleucine metabolic processIEA ISSbiological_process
GO:0006573Valine metabolic processIEA ISSbiological_process
GO:0006600Creatine metabolic processIEA ISSbiological_process
GO:0006631Fatty acid metabolic processIEA ISSbiological_process
GO:0006953Acute-phase responseIEAbiological_process
GO:0007259JAK-STAT cascadeTASbiological_process
GO:0007565Female pregnancyIEAbiological_process
GO:0007595LactationIEAbiological_process
GO:0019218Regulation of steroid metabolic processIEAbiological_process
GO:0019530Taurine metabolic processIEA ISSbiological_process
GO:0019903Protein phosphatase bindingIEAmolecular_function
GO:0019915Lipid storageIEAbiological_process
GO:0030155Regulation of cell adhesionIEAbiological_process
GO:0030856Regulation of epithelial cell differentiationIEAbiological_process
GO:0032355Response to estradiolIDAbiological_process
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0032819Positive regulation of natural killer cell proliferationIEAbiological_process
GO:0032825Positive regulation of natural killer cell differentiationIEAbiological_process
GO:0032870Cellular response to hormone stimulusIDAbiological_process
GO:0033077T cell differentiation in thymusIEAbiological_process
GO:0035259Glucocorticoid receptor bindingIPImolecular_function
GO:0038161Prolactin signaling pathwayIEA ISSbiological_process
GO:0040014Regulation of multicellular organism growthISSbiological_process
GO:0040018Positive regulation of multicellular organism growthIEAbiological_process
GO:0042104Positive regulation of activated T cell proliferationIEAbiological_process
GO:0042448Progesterone metabolic processIEAbiological_process
GO:0043029T cell homeostasisIEAbiological_process
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0045086Positive regulation of interleukin-2 biosynthetic processIEAbiological_process
GO:0045471Response to ethanolIEAbiological_process
GO:0045579Positive regulation of B cell differentiationIEAbiological_process
GO:0045588Positive regulation of gamma-delta T cell differentiationIEAbiological_process
GO:0045647Negative regulation of erythrocyte differentiationIEAbiological_process
GO:0045931Positive regulation of mitotic cell cycleIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEA ISSbiological_process
GO:0045954Positive regulation of natural killer cell mediated cytotoxicityIEAbiological_process
GO:0046449Creatinine metabolic processIEA ISSbiological_process
GO:0046543Development of secondary female sexual characteristicsIEAbiological_process
GO:0046544Development of secondary male sexual characteristicsIEAbiological_process
GO:0046983Protein dimerization activityISSmolecular_function
GO:0048541Peyer's patch developmentIEAbiological_process
GO:0048661Positive regulation of smooth muscle cell proliferationIEAbiological_process
GO:0050729Positive regulation of inflammatory responseIEAbiological_process
GO:0051272Positive regulation of cellular component movementIEAbiological_process
GO:0060397JAK-STAT cascade involved in growth hormone signaling pathwayIDA IEA TASbiological_process
GO:0070669Response to interleukin-2IEAbiological_process
GO:0070670Response to interleukin-4IEAbiological_process
GO:0070672Response to interleukin-15IEAbiological_process
GO:0071363Cellular response to growth factor stimulusISSbiological_process
GO:0071364Cellular response to epidermal growth factor stimulusISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.95049352990.28344038600.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3339854755
GSE13712_SHEARUp0.1351494330
GSE13712_STATICDown-0.1284932850
GSE19018Down-0.0564884274
GSE19899_A1Up0.0075539588
GSE19899_A2Down-0.1652506469
PubMed_21979375_A1Down-0.0713123717
PubMed_21979375_A2Up0.0205026521
GSE35957Up0.1814815524
GSE36640Down-0.4579933728
GSE54402Down-0.0595305072
GSE9593Down-0.1561149284
GSE43922Up0.0486532994
GSE24585Down-0.1330846373
GSE37065Down-0.0748201950
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Up0.0973423293

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

DasatinibDB01254 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-23b-3pMIMAT0000418MIRT023476SequencingFunctional MTI (Weak)20371350
hsa-miR-1229-3pMIMAT0005584MIRT036362CLASHFunctional MTI (Weak)23622248
hsa-miR-93-3pMIMAT0004509MIRT038811CLASHFunctional MTI (Weak)23622248
hsa-miR-324-3pMIMAT0000762MIRT042849CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.