HCSGD entry for STAT2
1. General information
| Official gene symbol | STAT2 |
|---|---|
| Entrez ID | 6773 |
| Gene full name | signal transducer and activator of transcription 2, 113kDa |
| Other gene symbols | ISGF-3 P113 STAT113 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0004871 | Signal transducer activity | IEA | molecular_function |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0007259 | JAK-STAT cascade | TAS | biological_process |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0019221 | Cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0051607 | Defense response to virus | IEA | biological_process |
| GO:0060337 | Type I interferon signaling pathway | TAS | biological_process |
| GO:0060338 | Regulation of type I interferon-mediated signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0429433342 | 0.1189567570 | 0.4618031008 | 0.6620978642 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1506184576 |
| GSE13712_SHEAR | Up | 0.9411689935 |
| GSE13712_STATIC | Up | 0.5977126456 |
| GSE19018 | Up | 0.3341703170 |
| GSE19899_A1 | Down | -0.3555919976 |
| GSE19899_A2 | Down | -0.4552563752 |
| PubMed_21979375_A1 | Down | -1.4749520897 |
| PubMed_21979375_A2 | Down | -0.5194812642 |
| GSE35957 | Down | -0.4618967663 |
| GSE36640 | Up | 0.5628277839 |
| GSE54402 | Down | -0.3407394144 |
| GSE9593 | Up | 0.2582485891 |
| GSE43922 | Down | -0.5721182786 |
| GSE24585 | Up | 1.1765944228 |
| GSE37065 | Up | 0.2953515419 |
| GSE28863_A1 | Up | 0.4643382918 |
| GSE28863_A2 | Up | 0.5976737346 |
| GSE28863_A3 | Down | -0.5515449782 |
| GSE28863_A4 | Down | -0.1865951836 |
| GSE48662 | Up | 0.4268352703 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017906 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-125a-5p | MIMAT0000443 | MIRT045759 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
