HCSGD entry for ZFP36L1
1. General information
| Official gene symbol | ZFP36L1 |
|---|---|
| Entrez ID | 677 |
| Gene full name | ZFP36 ring finger protein-like 1 |
| Other gene symbols | BRF1 Berg36 ERF-1 ERF1 RNF162B TIS11B cMG1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000288 | Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | IEA | biological_process |
| GO:0001570 | Vasculogenesis | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | NAS | molecular_function |
| GO:0003729 | MRNA binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006355 | Regulation of transcription, DNA-templated | NAS | biological_process |
| GO:0006417 | Regulation of translation | IEA | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0016071 | MRNA metabolic process | TAS | biological_process |
| GO:0033077 | T cell differentiation in thymus | IEA | biological_process |
| GO:0043488 | Regulation of mRNA stability | IDA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:2001141 | Regulation of RNA biosynthetic process | NAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1354313286 | 0.9395785343 | 0.7434939362 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0127243583 |
| GSE13712_SHEAR | Up | 0.1631622770 |
| GSE13712_STATIC | Up | 0.1378312036 |
| GSE19018 | Up | 0.1533824568 |
| GSE19899_A1 | Down | -0.0307919841 |
| GSE19899_A2 | Up | 0.2540969372 |
| PubMed_21979375_A1 | Up | 0.0954656181 |
| PubMed_21979375_A2 | Up | 0.0923196330 |
| GSE35957 | Up | 0.1871481044 |
| GSE36640 | Up | 0.1010152798 |
| GSE54402 | Down | -0.3314850043 |
| GSE9593 | Up | 0.0179255929 |
| GSE43922 | Up | 0.2338509779 |
| GSE24585 | Up | 0.4770330287 |
| GSE37065 | Up | 0.0281274726 |
| GSE28863_A1 | Up | 0.2738460349 |
| GSE28863_A2 | Up | 0.0418330345 |
| GSE28863_A3 | Up | 0.0449374027 |
| GSE28863_A4 | Up | 0.0575540077 |
| GSE48662 | Up | 0.3619284512 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-98-5p | MIMAT0000096 | MIRT004941 | qRT-PCR | Functional MTI (Weak) | 17942906 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT004957 | qRT-PCR | Functional MTI (Weak) | 17942906 |
| hsa-miR-423-5p | MIMAT0004748 | MIRT038046 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26280535 | In turn, MAPKAPK2 phosphorylates the RNA-binding protein ZFP36L1 during senescence, inhibiting its ability to degrade the transcripts of numerous SASP components |
| 26280535 | Consequently, mTOR inhibition or constitutive activation of ZFP36L1 impairs the non-cell-autonomous effects of senescent cells in both tumour-suppressive and tumour-promoting contexts |
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