HCSGD entry for ST13
1. General information
| Official gene symbol | ST13 |
|---|---|
| Entrez ID | 6767 |
| Gene full name | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) |
| Other gene symbols | AAG2 FAM10A1 FAM10A4 HIP HOP HSPABP HSPABP1 P48 PRO0786 SNC6 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0006457 | Protein folding | TAS | biological_process |
| GO:0019904 | Protein domain specific binding | IEA | molecular_function |
| GO:0030544 | Hsp70 protein binding | IEA | molecular_function |
| GO:0030674 | Protein binding, bridging | TAS | molecular_function |
| GO:0032403 | Protein complex binding | IEA | molecular_function |
| GO:0032564 | DATP binding | IEA | molecular_function |
| GO:0042802 | Identical protein binding | IEA | molecular_function |
| GO:0043234 | Protein complex | IEA | cellular_component |
| GO:0051082 | Unfolded protein binding | IEA | molecular_function |
| GO:0051087 | Chaperone binding | IEA | molecular_function |
| GO:0051260 | Protein homooligomerization | IEA | biological_process |
| GO:0061084 | Negative regulation of protein refolding | IEA | biological_process |
| GO:0070389 | Chaperone cofactor-dependent protein refolding | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1461821549 | 0.9511120132 | 0.7664062737 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3207184413 |
| GSE13712_SHEAR | Down | -0.2394142029 |
| GSE13712_STATIC | Down | -0.1624012322 |
| GSE19018 | Up | 0.1013060639 |
| GSE19899_A1 | Up | 0.3933561338 |
| GSE19899_A2 | Up | 0.2086041158 |
| PubMed_21979375_A1 | Down | -0.4117590331 |
| PubMed_21979375_A2 | Up | 0.1462547002 |
| GSE35957 | Up | 0.0259157158 |
| GSE36640 | Up | 0.2046221364 |
| GSE54402 | Up | 0.0625882457 |
| GSE9593 | Up | 0.3621603951 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Up | 0.1762591387 |
| GSE28863_A2 | Up | 0.2719850588 |
| GSE28863_A3 | Down | -0.0161880530 |
| GSE28863_A4 | Up | 0.0404263698 |
| GSE48662 | Up | 0.3300418244 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-186-5p | MIMAT0000456 | MIRT045078 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT047118 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052020 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21510971 | It has been reported that CHIP (C-terminus of Hsp70-interacting protein) ligase is induced during senescence while CHIP(-/-) mice exhibit accelerated aging |
| 18411298 | The carboxyl terminus of Hsp70-interacting protein (CHIP), a ubiquitin ligase/cochaperone, participates in protein quality control by targeting a broad range of chaperone substrates for proteasome degradation via the ubiquitin-proteasome system, demonstrating a broad involvement of CHIP in maintaining cytoplasmic protein quality control |
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