HCSGD entry for SRY
1. General information
| Official gene symbol | SRY |
|---|---|
| Entrez ID | 6736 |
| Gene full name | sex determining region Y |
| Other gene symbols | SRXX1 SRXY1 TDF TDY |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IDA IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0003705 | RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity | IDA | molecular_function |
| GO:0005516 | Calmodulin binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA IEA NAS | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0006366 | Transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0007548 | Sex differentiation | IEA | biological_process |
| GO:0008134 | Transcription factor binding | IPI | molecular_function |
| GO:0016607 | Nuclear speck | IEA | cellular_component |
| GO:0030154 | Cell differentiation | IEA | biological_process |
| GO:0030238 | Male sex determination | IEA NAS | biological_process |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA | biological_process |
| GO:2000020 | Positive regulation of male gonad development | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6426144713 | 0.8335216139 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0120731540 |
| GSE13712_SHEAR | Down | -0.0917655880 |
| GSE13712_STATIC | Down | -0.1223879422 |
| GSE19018 | Up | 0.0148623836 |
| GSE19899_A1 | Up | 0.2021385171 |
| GSE19899_A2 | Up | 0.2828819708 |
| PubMed_21979375_A1 | Down | -0.0564186618 |
| PubMed_21979375_A2 | Up | 0.0200647771 |
| GSE35957 | Up | 0.1112254886 |
| GSE36640 | Up | 0.1260005599 |
| GSE54402 | Down | -0.0564886488 |
| GSE9593 | Up | 0.0068641960 |
| GSE43922 | Up | 0.0194052339 |
| GSE24585 | Up | 0.0947927455 |
| GSE37065 | Up | 0.0498669861 |
| GSE28863_A1 | Down | -0.1241539193 |
| GSE28863_A2 | Down | -0.0965167821 |
| GSE28863_A3 | Up | 0.2945225741 |
| GSE28863_A4 | Down | -0.0601741554 |
| GSE48662 | Down | -0.0095226649 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25427424 | Previous studies have demonstrated that the developmental gene sex-determining region Y (SRY)-box 1 (SOX1) inhibits cervical and liver tumorigenesis by interfering with the Wnt/beta-catenin signaling pathway |
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