HCSGD entry for SRPK2

1. General information

Official gene symbolSRPK2
Entrez ID6733
Gene full nameSRSF protein kinase 2
Other gene symbolsSFRSK2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000245Spliceosomal complex assemblyIDAbiological_process
GO:0000287Magnesium ion bindingIDAmolecular_function
GO:0001525AngiogenesisISSbiological_process
GO:0004672Protein kinase activityIEAmolecular_function
GO:0004674Protein serine/threonine kinase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIDA IEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0006468Protein phosphorylationIDAbiological_process
GO:0008284Positive regulation of cell proliferationIDAbiological_process
GO:0008380RNA splicingIDAbiological_process
GO:0010628Positive regulation of gene expressionISSbiological_process
GO:0016772Transferase activity, transferring phosphorus-containing groupsIEAmolecular_function
GO:0030154Cell differentiationIEAbiological_process
GO:0035063Nuclear speck organizationISSbiological_process
GO:0035556Intracellular signal transductionIDAbiological_process
GO:0043525Positive regulation of neuron apoptotic processISSbiological_process
GO:0045070Positive regulation of viral genome replicationIDAbiological_process
GO:0045071Negative regulation of viral genome replicationIDAbiological_process
GO:0045087Innate immune responseICbiological_process
GO:0045787Positive regulation of cell cycleISSbiological_process
GO:0048024Regulation of mRNA splicing, via spliceosomeTASbiological_process
GO:007188914-3-3 protein bindingISSmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.86821287190.16950382960.99999024730.7962716937

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2673814018
GSE13712_SHEARDown-0.1153955492
GSE13712_STATICDown-0.1274793152
GSE19018Up0.0460461758
GSE19899_A1Down-0.2494435694
GSE19899_A2Down-0.1141153835
PubMed_21979375_A1Down-0.4161719355
PubMed_21979375_A2Down-0.4114601113
GSE35957Up0.2346881351
GSE36640Up0.2936876964
GSE54402Down-0.1211654274
GSE9593Up0.4882898252
GSE43922Down-0.1959529300
GSE24585Up0.1696107923
GSE37065Up0.1026120665
GSE28863_A1Down-0.1328154394
GSE28863_A2Up0.3235209534
GSE28863_A3Down-0.0162936017
GSE28863_A4Down-0.1147924047
GSE48662Down-0.4583508126

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

AdenineDB00173 NUTR00012 | EXPT00520
PurvalanolDB02733 EXPT02705
Phosphoaminophosphonic Acid-Adenylate EsterDB04395 EXPT00524

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT020912ProteomicsFunctional MTI (Weak)18668040
hsa-miR-181a-5pMIMAT0000256MIRT025155MicroarrayFunctional MTI (Weak)17612493
hsa-miR-21-5pMIMAT0000076MIRT030965MicroarrayFunctional MTI (Weak)18591254
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.