HCSGD entry for SRD5A1
1. General information
| Official gene symbol | SRD5A1 |
|---|---|
| Entrez ID | 6715 |
| Gene full name | steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) |
| Other gene symbols | S5AR 1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003865 | 3-oxo-5-alpha-steroid 4-dehydrogenase activity | IDA | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0006629 | Lipid metabolic process | IEA | biological_process |
| GO:0006702 | Androgen biosynthetic process | TAS | biological_process |
| GO:0007530 | Sex determination | NAS | biological_process |
| GO:0007548 | Sex differentiation | IEA | biological_process |
| GO:0008202 | Steroid metabolic process | TAS | biological_process |
| GO:0009055 | Electron carrier activity | TAS | molecular_function |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016627 | Oxidoreductase activity, acting on the CH-CH group of donors | IEA | molecular_function |
| GO:0030154 | Cell differentiation | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0047751 | Cholestenone 5-alpha-reductase activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0851084723 | 0.3657583602 | 0.6135589814 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4145657481 |
| GSE13712_SHEAR | Up | 0.0759315474 |
| GSE13712_STATIC | Up | 0.3435336988 |
| GSE19018 | Up | 0.1770923142 |
| GSE19899_A1 | Down | -1.1803796166 |
| GSE19899_A2 | Down | -0.1158444734 |
| PubMed_21979375_A1 | Down | -1.0611154708 |
| PubMed_21979375_A2 | Down | -0.4696183569 |
| GSE35957 | Up | 0.5779678855 |
| GSE36640 | Up | 0.3915982668 |
| GSE54402 | Down | -0.0430334514 |
| GSE9593 | Up | 0.8245256776 |
| GSE43922 | Down | -0.0957170703 |
| GSE24585 | Up | 0.1837138596 |
| GSE37065 | Down | -0.0572108478 |
| GSE28863_A1 | Down | -0.1428046509 |
| GSE28863_A2 | Up | 0.0212839854 |
| GSE28863_A3 | Up | 0.8188009279 |
| GSE28863_A4 | Down | -0.0058297563 |
| GSE48662 | Up | 0.0226321453 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Dutasteride | DB01126 | APRD00385 |
| Finasteride | DB01216 | APRD00632 | DB07774 |
| Norgestrel | DB09389 | - |
| Spironolactone | DB00421 | APRD01234 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-215-5p | MIMAT0000272 | MIRT024451 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026876 | Microarray | Functional MTI (Weak) | 19074876 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
