HCSGD entry for SRC
1. General information
| Official gene symbol | SRC |
|---|---|
| Entrez ID | 6714 |
| Gene full name | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) |
| Other gene symbols | ASV SRC1 c-SRC p60-Src |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004672 | Protein kinase activity | IDA TAS | molecular_function |
| GO:0004713 | Protein tyrosine kinase activity | EXP IDA TAS | molecular_function |
| GO:0004715 | Non-membrane spanning protein tyrosine kinase activity | TAS | molecular_function |
| GO:0005070 | SH3/SH2 adaptor activity | TAS | molecular_function |
| GO:0005102 | Receptor binding | IPI | molecular_function |
| GO:0005178 | Integrin binding | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | IDA | cellular_component |
| GO:0005764 | Lysosome | IDA | cellular_component |
| GO:0005770 | Late endosome | IDA | cellular_component |
| GO:0005829 | Cytosol | IDA TAS | cellular_component |
| GO:0005856 | Cytoskeleton | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IDA TAS | cellular_component |
| GO:0005901 | Caveola | IDA | cellular_component |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0007155 | Cell adhesion | IEA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007172 | Signal complex assembly | TAS | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0007265 | Ras protein signal transduction | TAS | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008543 | Fibroblast growth factor receptor signaling pathway | TAS | biological_process |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0016301 | Kinase activity | TAS | molecular_function |
| GO:0018108 | Peptidyl-tyrosine phosphorylation | IDA | biological_process |
| GO:0020037 | Heme binding | IDA | molecular_function |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0030900 | Forebrain development | IEA | biological_process |
| GO:0031295 | T cell costimulation | TAS | biological_process |
| GO:0032463 | Negative regulation of protein homooligomerization | IMP | biological_process |
| GO:0033146 | Regulation of intracellular estrogen receptor signaling pathway | IEA | biological_process |
| GO:0033625 | Positive regulation of integrin activation | TAS | biological_process |
| GO:0035556 | Intracellular signal transduction | IDA | biological_process |
| GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | TAS | biological_process |
| GO:0042169 | SH2 domain binding | IPI | molecular_function |
| GO:0042802 | Identical protein binding | IEA | molecular_function |
| GO:0043066 | Negative regulation of apoptotic process | IMP | biological_process |
| GO:0043114 | Regulation of vascular permeability | TAS | biological_process |
| GO:0043154 | Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | IMP | biological_process |
| GO:0043393 | Regulation of protein binding | IEA | biological_process |
| GO:0044325 | Ion channel binding | IPI | molecular_function |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0045124 | Regulation of bone resorption | TAS | biological_process |
| GO:0045453 | Bone resorption | ISS | biological_process |
| GO:0046777 | Protein autophosphorylation | IDA | biological_process |
| GO:0046875 | Ephrin receptor binding | IPI | molecular_function |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0048477 | Oogenesis | IEA | biological_process |
| GO:0050847 | Progesterone receptor signaling pathway | ISS | biological_process |
| GO:0050900 | Leukocyte migration | TAS | biological_process |
| GO:0051219 | Phosphoprotein binding | IPI | molecular_function |
| GO:0051895 | Negative regulation of focal adhesion assembly | ISS | biological_process |
| GO:0051897 | Positive regulation of protein kinase B signaling | IMP | biological_process |
| GO:0051902 | Negative regulation of mitochondrial depolarization | IMP | biological_process |
| GO:0060065 | Uterus development | IEA | biological_process |
| GO:0060444 | Branching involved in mammary gland duct morphogenesis | IEA | biological_process |
| GO:0070374 | Positive regulation of ERK1 and ERK2 cascade | IEA | biological_process |
| GO:0070555 | Response to interleukin-1 | IMP | biological_process |
| GO:0070851 | Growth factor receptor binding | IPI | molecular_function |
| GO:0071393 | Cellular response to progesterone stimulus | ISS | biological_process |
| GO:0071803 | Positive regulation of podosome assembly | IEA | biological_process |
| GO:0090263 | Positive regulation of canonical Wnt signaling pathway | IEA | biological_process |
| GO:2000811 | Negative regulation of anoikis | IMP | biological_process |
| GO:2001237 | Negative regulation of extrinsic apoptotic signaling pathway | IMP | biological_process |
| GO:2001243 | Negative regulation of intrinsic apoptotic signaling pathway | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8846826678 | 0.5501952775 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0718198068 |
| GSE13712_SHEAR | Up | 0.2115806358 |
| GSE13712_STATIC | Up | 0.0474522045 |
| GSE19018 | Down | -0.0848133186 |
| GSE19899_A1 | Up | 0.0105188506 |
| GSE19899_A2 | Up | 0.0828322903 |
| PubMed_21979375_A1 | Down | -0.1155426088 |
| PubMed_21979375_A2 | Down | -0.0195696986 |
| GSE35957 | Up | 0.2388890287 |
| GSE36640 | Up | 0.0300459449 |
| GSE54402 | Up | 0.0857278199 |
| GSE9593 | Up | 0.1232591762 |
| GSE43922 | Up | 0.0419515298 |
| GSE24585 | Down | -0.2883262842 |
| GSE37065 | Down | -0.0738153964 |
| GSE28863_A1 | Up | 0.0682445266 |
| GSE28863_A2 | Down | -0.2118808528 |
| GSE28863_A3 | Up | 0.0362855078 |
| GSE28863_A4 | Down | -0.1728355047 |
| GSE48662 | Down | -0.0765584396 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-23b-3p | MIMAT0000418 | MIRT007051 | Luciferase reporter assay | Functional MTI | 23074286 |
| hsa-miR-33a-5p | MIMAT0000091 | MIRT007357 | Immunofluorescence//Luciferase reporter assay//Western blot | Functional MTI | 23547260 |
| hsa-miR-205-5p | MIMAT0000266 | MIRT024971 | Reporter assay | Functional MTI | 21330408 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23178160 | We found that the synthetic progestin medroxyprogesterone acetate (MPA) upregulates p21(CIP1) protein expression via c-Src, signal transducer and activator of transcription 3 (Stat3) and ErbB-2 phosphorylation |
| 15742196 | Among the focal adhesion proteins, paxillin and c-Src decreased also |
| 6288392 | Under conditions employed in our laboratory, tumors which are induced by avian sarcoma virus (ASV) usually grow progressively for several weeks and then regress |
| 6288392 | The results indicate that tumor cells which are derived from progressively-growing sarcomas are rapidly growing, produce large quantities of the enzyme plasminogen activator, and have much in common generally with chicken embryo fibroblast (CEF) cells that have been transformed by ASV |
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