HCSGD entry for SPTAN1
1. General information
| Official gene symbol | SPTAN1 |
|---|---|
| Entrez ID | 6709 |
| Gene full name | spectrin, alpha, non-erythrocytic 1 |
| Other gene symbols | EIEE5 NEAS SPTA2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003779 | Actin binding | IEA | molecular_function |
| GO:0005200 | Structural constituent of cytoskeleton | TAS | molecular_function |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005516 | Calmodulin binding | IEA | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005916 | Fascia adherens | IEA | cellular_component |
| GO:0006915 | Apoptotic process | TAS | biological_process |
| GO:0006921 | Cellular component disassembly involved in execution phase of apoptosis | TAS | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0008091 | Spectrin | TAS | cellular_component |
| GO:0015630 | Microtubule cytoskeleton | IDA | cellular_component |
| GO:0016020 | Membrane | TAS | cellular_component |
| GO:0016328 | Lateral plasma membrane | IEA | cellular_component |
| GO:0030018 | Z disc | IEA | cellular_component |
| GO:0030507 | Spectrin binding | IEA | molecular_function |
| GO:0032437 | Cuticular plate | IEA | cellular_component |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0046982 | Protein heterodimerization activity | IEA | molecular_function |
| GO:0051693 | Actin filament capping | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0232588845 | 0.9120443410 | 0.3626760071 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2475122962 |
| GSE13712_SHEAR | Up | 0.0903955972 |
| GSE13712_STATIC | Down | -0.0282263830 |
| GSE19018 | Down | -0.0643903493 |
| GSE19899_A1 | Up | 0.0820412469 |
| GSE19899_A2 | Up | 0.4757636564 |
| PubMed_21979375_A1 | Up | 0.7922002612 |
| PubMed_21979375_A2 | Up | 1.1120552671 |
| GSE35957 | Up | 0.0919236044 |
| GSE36640 | Up | 0.6812582016 |
| GSE54402 | Up | 0.0322915766 |
| GSE9593 | Up | 0.0142245173 |
| GSE43922 | Down | -0.0125769952 |
| GSE24585 | Up | 0.0481244240 |
| GSE37065 | Up | 0.0317707014 |
| GSE28863_A1 | Up | 1.1242424996 |
| GSE28863_A2 | Up | 0.9405589657 |
| GSE28863_A3 | Down | -0.4555078022 |
| GSE28863_A4 | Up | 0.0843379736 |
| GSE48662 | Up | 0.6709872459 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025260 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-93-3p | MIMAT0004509 | MIRT038805 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043347 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
