HCSGD entry for SPTA1

1. General information

Official gene symbolSPTA1
Entrez ID6708
Gene full namespectrin, alpha, erythrocytic 1 (elliptocytosis 2)
Other gene symbolsEL2 HPP HS3 SPH3 SPTA
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002260Lymphocyte homeostasisIEAbiological_process
GO:0005200Structural constituent of cytoskeletonTASmolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005829CytosolTAScellular_component
GO:0006779Porphyrin-containing compound biosynthetic processIEAbiological_process
GO:0007009Plasma membrane organizationIEAbiological_process
GO:0007015Actin filament organizationTASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0008091SpectrinTAScellular_component
GO:0008360Regulation of cell shapeIEAbiological_process
GO:0014731Spectrin-associated cytoskeletonIDAcellular_component
GO:0015629Actin cytoskeletonTAScellular_component
GO:0030097HemopoiesisIEAbiological_process
GO:0031235Intrinsic component of the cytoplasmic side of the plasma membraneTAScellular_component
GO:0032092Positive regulation of protein bindingIEAbiological_process
GO:0032437Cuticular plateIEAcellular_component
GO:0042102Positive regulation of T cell proliferationIEAbiological_process
GO:0046982Protein heterodimerization activityIEAmolecular_function
GO:0051015Actin filament bindingTASmolecular_function
GO:0051693Actin filament cappingIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.66738533490.79524102430.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0490265964
GSE13712_SHEARDown-0.3365666476
GSE13712_STATICDown-0.0696227224
GSE19018Down-0.0169467495
GSE19899_A1Up0.4191854186
GSE19899_A2Up0.0293784649
PubMed_21979375_A1Down-0.0926058519
PubMed_21979375_A2Up0.1051710404
GSE35957Up0.0030344407
GSE36640Down-0.0883507165
GSE54402Up0.0385143079
GSE9593Down-0.0560361719
GSE43922Up0.0050151692
GSE24585Up0.1194566741
GSE37065Down-0.0539963981
GSE28863_A1Up0.0266233656
GSE28863_A2Up0.0640884852
GSE28863_A3Up0.0854244259
GSE28863_A4Up0.0506481933
GSE48662Up0.0586968899

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022113MicroarrayFunctional MTI (Weak)18668037
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

17901699The aim of this work was to investigate the level of condensation, methylation and transcriptional status of centromeric (alphoid DNA) and pericentromeric satellites (human satellite 3, HS3) in tissues (lymphocytes, placenta cells) and in cultured primary (MRC5, VH-10, AT2Sp) and malignant (A431) cells
17901699The HS3 of chromosome 1 (HS3-1) but not of chromosome 9 (HS3-9) was strongly decondensed and demethylated in A431 cells
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