HCSGD entry for SPP1
1. General information
| Official gene symbol | SPP1 |
|---|---|
| Entrez ID | 6696 |
| Gene full name | secreted phosphoprotein 1 |
| Other gene symbols | BNSP BSPI ETA-1 OPN |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001503 | Ossification | IEA | biological_process |
| GO:0001649 | Osteoblast differentiation | IEA | biological_process |
| GO:0005125 | Cytokine activity | IEA | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005615 | Extracellular space | IDA | cellular_component |
| GO:0006954 | Inflammatory response | IEA | biological_process |
| GO:0007155 | Cell adhesion | IEA | biological_process |
| GO:0007566 | Embryo implantation | TAS | biological_process |
| GO:0010811 | Positive regulation of cell-substrate adhesion | IEA | biological_process |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0030593 | Neutrophil chemotaxis | IEA | biological_process |
| GO:0031214 | Biomineral tissue development | IEA | biological_process |
| GO:0031988 | Membrane-bounded vesicle | IEA | cellular_component |
| GO:0033280 | Response to vitamin D | IDA | biological_process |
| GO:0042995 | Cell projection | IEA | cellular_component |
| GO:0045177 | Apical part of cell | IEA | cellular_component |
| GO:0045780 | Positive regulation of bone resorption | IEA | biological_process |
| GO:0046697 | Decidualization | TAS | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0048545 | Response to steroid hormone | IEA | biological_process |
| GO:0048685 | Negative regulation of collateral sprouting of intact axon in response to injury | IEA | biological_process |
| GO:0050840 | Extracellular matrix binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0007312450 | 0.8867463812 | 0.0773316602 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 3.8478430033 |
| GSE13712_SHEAR | Up | 0.0367781022 |
| GSE13712_STATIC | Down | -0.0416942273 |
| GSE19018 | Down | -0.0767257931 |
| GSE19899_A1 | Up | 0.4008013908 |
| GSE19899_A2 | Up | 1.5402373110 |
| PubMed_21979375_A1 | Up | 1.4786557433 |
| PubMed_21979375_A2 | Up | 2.5583756124 |
| GSE35957 | Down | -0.8667598306 |
| GSE36640 | Down | -0.0616274079 |
| GSE54402 | Up | 1.8620234087 |
| GSE9593 | Up | 0.8491234075 |
| GSE43922 | Up | 2.1589563351 |
| GSE24585 | Up | 0.0425274771 |
| GSE37065 | Up | 0.5593706438 |
| GSE28863_A1 | Down | -0.2624995507 |
| GSE28863_A2 | Up | 0.0294736344 |
| GSE28863_A3 | Down | -0.0287040675 |
| GSE28863_A4 | Down | -0.1364472272 |
| GSE48662 | Up | 0.3273479066 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-299-5p | MIMAT0002890 | MIRT004565 | immunoblot//qRT-PCR//Luciferase reporter assay//Microarray | Functional MTI | 19538464 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT016866 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-146a-5p | MIMAT0000449 | MIRT021279 | qRT-PCR | Functional MTI (Weak) | 20110513 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 9 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27165403 | The onset of senescence inhibited both the induction of osteoblast markers RUNX2 and osteopontin and the biomineralization of DFCs after stimulation of the osteogenic differentiation |
| 26629698 | Cellular senescence is defined as an irreversible cell cycle arrest and is associated with the release of molecules known as the senescence-associated secretory phenotype that can selectively promote the growth of pre-neoplastic keratinocytes (osteopontin) and cancer invasion (transforming growth factor beta, matrix metalloproteinases, interleukin 6 and lactate) |
| 26477312 | In addition to the activation of oncogenes c-MYC and STAT3 in tumor cells, a number of cytokines and growth factors, such as IL1beta, IL6 and SPP1 (osteopontin, a key biomarker for PCa), were upregulated in NFATc1-induced PCa, establishing a tumorigenic microenvironment involving both NFATc1 positive and negative cells for prostate tumorigenesis |
| 25972477 | A CD153+CD4+ T follicular cell population with cell-senescence features plays a crucial role in lupus pathogenesis via osteopontin production |
| 25972477 | Although the CD153(+) TF cells were defective in proliferation capacity, they were quite stable and specifically responded to self GC-B cells to secret abundant osteopontin, which inhibited B cell receptor-induced GC-B cell apoptosis in f-BWF1 mice |
| 22340562 | Silencing of osteopontin promotes the radiosensitivity of breast cancer cells by reducing the expression of hypoxia inducible factor 1 and vascular endothelial growth factor |
| 22340562 | BACKGROUND: Osteopontin (OPN) is a secreted phosphoglycoprotein (SSP) that is overexpressed in a variety of tumors and was regarded as a molecular marker of tumors |
| 22340562 | In this study, we intended to demonstrate the role of OPN in human breast cancer cell line MDA-MB-231 |
| 22340562 | METHODS: Recombinant plasmid expressing small interfering RNA (siRNA) specific to OPN mRNA was transfected into MDA-MB-231 cells to generate the stable transfected cell line MDA-MB-343, and the empty plasmid tansfected cells (MDA-MB-neg) or wildtype MDA-MB-231 cells were used as control cells respectively |
| 22340562 | Expression of OPN, hypoxia inducible factor-1 (HIF-1) and vascular endothelial growth factor (VEGF) proteins was analyzed by Western blotting analysis |
| 22340562 | RESULTS: HIF-1 and VEGF proteins in MDA-MB-343 cells were significantly downregulated upon the efficient knockdown of OPN expression under either hypoxia or normoxia environment |
| 22340562 | Moreover, expression of OPN protein was upregualted upon hypoxic culture |
| 22340562 | CONCLUSIONS: Suppression of OPN gene expression can enhance radiosensitivity and affect cell apoptosis in breast cancer cells |
| 22340562 | OPN seems to be an attractive target for the improvement of radiotherapy |
| 22302986 | Tiam1-regulated osteopontin in senescent fibroblasts contributes to the migration and invasion of associated epithelial cells |
| 22302986 | We find that stress-induced senescence induces decreased fibroblast Tiam1 protein levels and increased osteopontin levels, and that senescent fibroblast lysates induce Tiam1 protein degradation in a calcium- and calpain-dependent fashion |
| 22302986 | Changes in fibroblast Tiam1 protein levels induce converse changes in osteopontin mRNA and protein |
| 22302986 | These effects in epithelial cells are ameliorated by either increasing fibroblast Tiam1 or decreasing fibroblast osteopontin |
| 22302986 | Finally, in seeded cell migration assays we find that either senescent or Tiam1-deficient fibroblasts induce increased epithelial cell migration that is dependent on fibroblast secretion of osteopontin |
| 22302986 | These findings indicate that one mechanism by which senescent fibroblasts promote neoplastic progression in associated tumors is through degradation of fibroblast Tiam1 protein and the consequent increase in secretion of osteopontin by fibroblasts |
| 22067611 | Also examined were the expression of genes involved in proliferation and mineralization such as human alkaline phosphatase (ALP), beta-actin, collagen 1 (col-1), core binding factor (cbfa-1), dentin matrix protein (DMP-1), dentin sialophosphoprotein (DSPP), GAPDH, hTERT, osteocalcin (OCN), osteopontin (OPN) as well as oncoproteins involved in senescence (p16, p21 and p53) using RT-PCR |
| 19449178 | Increases in CTS-induced osteopontin (OPN) synthesis, cyclooxygenase-2 (Cox-2) mRNA expression, and nitric oxide (NO) production by osteoblasts did not change at the third and fifth passages |
| 19155301 | Senescent stromal-derived osteopontin promotes preneoplastic cell growth |
| 19155301 | We identified osteopontin (OPN) as one of the most highly elevated transcripts in senescent fibroblasts |
| 19155301 | Importantly, reduction of OPN protein levels by RNA interference did not affect senescence induction in fibroblasts; however, it dramatically reduced the growth-promoting activities of senescent fibroblasts in vitro and in vivo, showing that OPN is necessary for paracrine stimulation of preneoplastic cell growth |
| 19155301 | In addition, we found that recombinant OPN was sufficient to stimulate preneoplastic cell growth |
| 19155301 | Finally, we show that OPN is expressed in senescent stroma within preneoplastic lesions that arise following 7,12-dimethylbenz(a)anthracene/12-O-tetradecanoylphorbol-13-acetate treatment of mice, suggesting that stromal-derived OPN-mediated signaling events affect neoplastic progression |
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