HCSGD entry for SPINK1
1. General information
| Official gene symbol | SPINK1 |
|---|---|
| Entrez ID | 6690 |
| Gene full name | serine peptidase inhibitor, Kazal type 1 |
| Other gene symbols | PCTT PSTI Spink3 TATI TCP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004866 | Endopeptidase inhibitor activity | TAS | molecular_function |
| GO:0004867 | Serine-type endopeptidase inhibitor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0010751 | Negative regulation of nitric oxide mediated signal transduction | IEA | biological_process |
| GO:0050732 | Negative regulation of peptidyl-tyrosine phosphorylation | IEA | biological_process |
| GO:0060046 | Regulation of acrosome reaction | IEA | biological_process |
| GO:0090281 | Negative regulation of calcium ion import | IEA | biological_process |
| GO:1900004 | Negative regulation of serine-type endopeptidase activity | IEA | biological_process |
| GO:2001256 | Regulation of store-operated calcium entry | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0390338741 | 0.9787832377 | 0.4453448635 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 1.3701352632 |
| GSE13712_SHEAR | Up | 0.1087152116 |
| GSE13712_STATIC | Down | -0.0976872691 |
| GSE19018 | Up | 0.1578396141 |
| GSE19899_A1 | Up | 0.0321574494 |
| GSE19899_A2 | Up | 0.3004968918 |
| PubMed_21979375_A1 | Up | 0.7159406123 |
| PubMed_21979375_A2 | Up | 0.0179550356 |
| GSE35957 | Down | -0.0677046889 |
| GSE36640 | Up | 0.3128070808 |
| GSE54402 | Up | 0.2575124074 |
| GSE9593 | Up | 0.0808997276 |
| GSE43922 | Up | 0.2785651371 |
| GSE24585 | Down | -0.0105064403 |
| GSE37065 | Up | 0.3383605600 |
| GSE28863_A1 | Up | 0.0184189731 |
| GSE28863_A2 | Up | 0.2476228465 |
| GSE28863_A3 | Up | 0.1419430084 |
| GSE28863_A4 | Up | 0.0180139527 |
| GSE48662 | Up | 0.3506080217 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT023710 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
